Arhgap22 Rho GTPase activating protein 22 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap22provided by MGI
Official Full Name: Rho GTPase activating protein 22provided by MGI
Primary source: MGI:MGI:2443418
See related: Ensembl:ENSMUSG00000063506 AllianceGenome:MGI:2443418
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RHOGAP2; p68RacGAP; B230341L19Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction and regulation of postsynapse organization. Predicted to be located in cytoplasm and nucleus. Predicted to be active in glutamatergic synapse. Orthologous to human ARHGAP22 (Rho GTPase activating protein 22). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 3.9), ovary adult (RPKM 3.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 20.15 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (32935952..33091893)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (33213994..33369936)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice.
Title: Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice.
a multifunctional regulatory protein with Rac1-specific GTPase-activating activity; regulates transcriptional activity of the endothelin-1 promoter; involved in the signal transduction pathway regulating endothelial cell capillary tube formation
Title: p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14Mit175 (e-PCR), detects polymorphism
- UniSTS:127287

D14Mit188 (e-PCR), detects polymorphism
- UniSTS:127300

fb36d11.x1 (e-PCR)
- UniSTS:203146

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of small GTPase mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rho GTPase-activating protein 22

Names: rho-type GTPase-activating protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153800.4 → NP_722495.3 rho GTPase-activating protein 22

See identical proteins and their annotated locations for NP_722495.3

Status: VALIDATED

Source sequence(s)

AK046097, AK078218, BB370610

Consensus CDS

CCDS26926.2

UniProtKB/Swiss-Prot

Q6QHH6, Q8BL80, Q8BVH4, Q8CHY5

Related

ENSMUSP00000107587.3, ENSMUST00000111956.9

Conserved Domains (4) summary

cd04390
Location:157 → 355

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam07111
Location:602 → 683

HCR; Alpha helical coiled-coil rod protein (HCR)

pfam09726
Location:493 → 683

Macoilin; Macoilin family

cl17171
Location:42 → 157

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

32935952..33091893

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518956.5 → XP_006519019.1 rho GTPase-activating protein 22 isoform X3

Conserved Domains (3) summary

cd04390
Location:173 → 371

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

TIGR02168
Location:610 → 698

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl17171
Location:42 → 157

PH-like; Pleckstrin homology-like domain
XM_011245053.4 → XP_011243355.1 rho GTPase-activating protein 22 isoform X5

See identical proteins and their annotated locations for XP_011243355.1

UniProtKB/Swiss-Prot

Q6QHH6, Q8BL80, Q8BVH4, Q8CHY5

Conserved Domains (4) summary

cd04390
Location:157 → 355

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam07111
Location:602 → 683

HCR; Alpha helical coiled-coil rod protein (HCR)

pfam09726
Location:493 → 683

Macoilin; Macoilin family

cl17171
Location:42 → 157

PH-like; Pleckstrin homology-like domain
XM_036158588.1 → XP_036014481.1 rho GTPase-activating protein 22 isoform X3

Conserved Domains (3) summary

cd04390
Location:173 → 371

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

TIGR02168
Location:610 → 698

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl17171
Location:42 → 157

PH-like; Pleckstrin homology-like domain
XM_006518957.5 → XP_006519020.1 rho GTPase-activating protein 22 isoform X4

Conserved Domains (4) summary

cd04390
Location:167 → 365

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam07111
Location:612 → 693

HCR; Alpha helical coiled-coil rod protein (HCR)

pfam09726
Location:503 → 693

Macoilin; Macoilin family

cl17171
Location:36 → 151

PH-like; Pleckstrin homology-like domain
XM_030247787.2 → XP_030103647.1 rho GTPase-activating protein 22 isoform X6

Conserved Domains (4) summary

cd04390
Location:151 → 349

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam07111
Location:596 → 677

HCR; Alpha helical coiled-coil rod protein (HCR)

pfam09726
Location:487 → 677

Macoilin; Macoilin family

cl17171
Location:36 → 151

PH-like; Pleckstrin homology-like domain
XM_006518954.5 → XP_006519017.1 rho GTPase-activating protein 22 isoform X1

Conserved Domains (4) summary

cd04390
Location:193 → 391

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam07111
Location:638 → 719

HCR; Alpha helical coiled-coil rod protein (HCR)

pfam09726
Location:529 → 719

Macoilin; Macoilin family

cl17171
Location:62 → 177

PH-like; Pleckstrin homology-like domain
XM_017316004.3 → XP_017171493.1 rho GTPase-activating protein 22 isoform X2

Conserved Domains (4) summary

cd04390
Location:177 → 375

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam07111
Location:622 → 703

HCR; Alpha helical coiled-coil rod protein (HCR)

pfam09726
Location:513 → 703

Macoilin; Macoilin family

cl17171
Location:62 → 177

PH-like; Pleckstrin homology-like domain
XM_017316006.3 → XP_017171495.1 rho GTPase-activating protein 22 isoform X7

Conserved Domains (4) summary

cd04390
Location:134 → 332

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam07111
Location:579 → 660

HCR; Alpha helical coiled-coil rod protein (HCR)

pfam09726
Location:470 → 660

Macoilin; Macoilin family

cl17171
Location:62 → 147

PH-like; Pleckstrin homology-like domain
XM_006518959.3 → XP_006519022.1 rho GTPase-activating protein 22 isoform X8

UniProtKB/TrEMBL

D3Z1Y5

Conserved Domains (4) summary

cd04390
Location:77 → 275

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam07111
Location:522 → 603

HCR; Alpha helical coiled-coil rod protein (HCR)

pfam09726
Location:413 → 603

Macoilin; Macoilin family

cl17171
Location:18 → 61

PH-like; Pleckstrin homology-like domain
XM_006518961.5 → XP_006519024.1 rho GTPase-activating protein 22 isoform X10

UniProtKB/TrEMBL

D3Z1Y5

Related

ENSMUSP00000107586.2, ENSMUST00000111955.2

Conserved Domains (4) summary

cd04390
Location:61 → 259

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam07111
Location:506 → 587

HCR; Alpha helical coiled-coil rod protein (HCR)

pfam09726
Location:397 → 587

Macoilin; Macoilin family

cl17171
Location:18 → 61

PH-like; Pleckstrin homology-like domain
XM_036158589.1 → XP_036014482.1 rho GTPase-activating protein 22 isoform X13

UniProtKB/TrEMBL

D3Z1Y5

Conserved Domains (2) summary

cd04390
Location:18 → 216

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

TIGR02168
Location:455 → 543

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_006518960.4 → XP_006519023.1 rho GTPase-activating protein 22 isoform X9

UniProtKB/TrEMBL

D3Z1Y5

Conserved Domains (4) summary

cd04390
Location:77 → 275

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam07111
Location:522 → 603

HCR; Alpha helical coiled-coil rod protein (HCR)

pfam09726
Location:413 → 603

Macoilin; Macoilin family

cl17171
Location:18 → 61

PH-like; Pleckstrin homology-like domain
XM_006518962.4 → XP_006519025.1 rho GTPase-activating protein 22 isoform X11

UniProtKB/TrEMBL

D3Z1Y5

Related

ENSMUST00000137590.8

Conserved Domains (4) summary

cd04390
Location:61 → 259

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam07111
Location:506 → 587

HCR; Alpha helical coiled-coil rod protein (HCR)

pfam09726
Location:397 → 587

Macoilin; Macoilin family

cl17171
Location:18 → 61

PH-like; Pleckstrin homology-like domain
XM_006518963.5 → XP_006519026.1 rho GTPase-activating protein 22 isoform X12

UniProtKB/TrEMBL

D3Z1Y5

Conserved Domains (3) summary

cd04390
Location:33 → 231

RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

pfam07111
Location:478 → 559

HCR; Alpha helical coiled-coil rod protein (HCR)

pfam09726
Location:369 → 559

Macoilin; Macoilin family
XM_011245054.1 → XP_011243356.1 rho GTPase-activating protein 22 isoform X14

Conserved Domains (3) summary

TIGR02168
Location:286 → 374

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam09726
Location:185 → 375

Macoilin; Macoilin family

cl02570
Location:1 → 47

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...