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    Zdhhc22 zinc finger, DHHC-type containing 22 [ Mus musculus (house mouse) ]

    Gene ID: 238331, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Zdhhc22provided by MGI
    Official Full Name
    zinc finger, DHHC-type containing 22provided by MGI
    Primary source
    MGI:MGI:2685108
    See related
    Ensembl:ENSMUSG00000048483 AllianceGenome:MGI:2685108
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm262
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Acts upstream of or within protein localization to plasma membrane and protein palmitoylation. Predicted to be located in plasma membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC22 (zinc finger DHHC-type palmitoyltransferase 22). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in cortex adult (RPKM 9.7), frontal lobe adult (RPKM 6.5) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zdhhc22 in Genome Data Viewer
    Location:
    12 D2; 12 41.17 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (87027537..87037604, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (86980763..86990830, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32856 Neighboring gene predicted gene, 53735 Neighboring gene STARR-seq mESC enhancer starr_32861 Neighboring gene STARR-seq mESC enhancer starr_32863 Neighboring gene STARR-seq mESC enhancer starr_32864 Neighboring gene STARR-positive B cell enhancer ABC_E10769 Neighboring gene predicted gene, 32934 Neighboring gene CLOCK interacting protein, circadian Neighboring gene transmembrane protein 63c Neighboring gene crumbs homolog 1 pseudogene Neighboring gene neuroglobin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CCN3 secretion is regulated by palmitoylation via ZDHHC22. Kim Y, et al. Biochem Biophys Res Commun, 2018 Jan 22. PMID 29287726
    2. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. Tian L, et al. J Biol Chem, 2012 Apr 27. PMID 22399288, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Clone Names

    • MGC157624

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein palmitoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC22
    Names
    DHHC-22
    putative palmitoyltransferase ZDHHC22
    zinc finger DHHC domain-containing protein 22
    NP_001074412.1
    NP_001363954.1
    XP_006515916.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080943.3 → NP_001074412.1  palmitoyltransferase ZDHHC22

      See identical proteins and their annotated locations for NP_001074412.1

      Status: VALIDATED

      Source sequence(s)
      AC153147
      Consensus CDS
      CCDS36500.1
      UniProtKB/Swiss-Prot
      A0PK84
      Related
      ENSMUSP00000152660.2, ENSMUST00000222543.2
      Conserved Domains (1) summary
      pfam01529
      Location:91 → 218
      DHHC; DHHC palmitoyltransferase

    2. NM_001377025.1 → NP_001363954.1  palmitoyltransferase ZDHHC22

      Status: VALIDATED

      Source sequence(s)
      AC153147
      UniProtKB/Swiss-Prot
      A0PK84
      Related
      ENSMUSP00000093177.3, ENSMUST00000095521.3
      Conserved Domains (1) summary
      pfam01529
      Location:91 → 218
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      87027537..87037604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515853.5 → XP_006515916.1  palmitoyltransferase ZDHHC22 isoform X1

      Conserved Domains (1) summary
      pfam01529
      Location:91 → 180
      DHHC; DHHC palmitoyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0PK84.1 GenPept UniProtKB/Swiss-Prot:A0PK84

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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