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    Cib3 calcium and integrin binding family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 234421, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Cib3provided by MGI
    Official Full Name
    calcium and integrin binding family member 3provided by MGI
    Primary source
    MGI:MGI:2685953
    See related
    Ensembl:ENSMUSG00000074240 AllianceGenome:MGI:2685953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KIP3; Gm1107; C730014M21Rik
    Summary
    Predicted to enable calcium ion binding activity and magnesium ion binding activity. Predicted to be involved in calcium ion homeostasis. Is expressed in skeletal muscle. Orthologous to human CIB3 (calcium and integrin binding family member 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Cib3 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.88 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72958180..72966892, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72204335..72213086, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11387 Neighboring gene RAB8A, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E8246 Neighboring gene hematopoietic SH2 domain containing Neighboring gene STARR-positive B cell enhancer ABC_E9026 Neighboring gene family with sequence similarity 32, member A Neighboring gene STARR-positive B cell enhancer ABC_E2266 Neighboring gene predicted gene, 51536 Neighboring gene adaptor-related protein complex AP-1, mu subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells. Wang X, et al. J Neurosci, 2023 May 3. PMID 37001993, Free PMC Article
    2. Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy. Häger M, et al. J Biol Chem, 2008 Sep 5. PMID 18611855, Free PMC Article
    3. CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells. Giese APJ, et al. Nat Commun, 2017 Jun 29. PMID 28663585, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells.
      Title: CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    calcium and integrin-binding family member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080812.2 → NP_001074281.1  calcium and integrin-binding family member 3 isoform 2

      See identical proteins and their annotated locations for NP_001074281.1

      Status: VALIDATED

      Source sequence(s)
      AC158898
      Consensus CDS
      CCDS52594.1
      UniProtKB/Swiss-Prot
      Q0P523
      Related
      ENSMUSP00000096231.4, ENSMUST00000098630.5
      Conserved Domains (2) summary
      cd00051
      Location:84 → 146
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:81 → 146
      EF-hand_7; EF-hand domain pair

    2. NM_001411781.1 → NP_001398710.1  calcium and integrin-binding family member 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC158898
      UniProtKB/TrEMBL
      A0A5F8MPX9
      Related
      ENSMUSP00000159168.2, ENSMUST00000238973.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      72958180..72966892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0P523.1 GenPept UniProtKB/Swiss-Prot:Q0P523

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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