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    Ldaf1 lipid droplet assembly factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 233806, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ldaf1provided by MGI
    Official Full Name
    lipid droplet assembly factor 1provided by MGI
    Primary source
    MGI:MGI:1925752
    See related
    Ensembl:ENSMUSG00000030917 AllianceGenome:MGI:1925752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem159; 8430420C20Rik
    Summary
    Predicted to be involved in lipid droplet formation. Predicted to be located in endoplasmic reticulum membrane and lipid droplet. Orthologous to human LDAF1 (lipid droplet assembly factor 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in bladder adult (RPKM 36.8), adrenal adult (RPKM 35.1) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ldaf1 in Genome Data Viewer
    Location:
    7 F2; 7 64.37 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119701599..119720212)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120102342..120120987)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 3 Neighboring gene predicted gene, 25217 Neighboring gene ribosomal protein S9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20042 Neighboring gene RIKEN cDNA 4930505K13 gene Neighboring gene STARR-seq mESC enhancer starr_20043 Neighboring gene zona pellucida glycoprotein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. Yu S, et al. Biochimie, 2004 Nov. PMID 15589683
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid droplet formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lipid droplet assembly factor 1
    Names
    promethin
    transmembrane protein 159

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419290.1 → NP_001406219.1  lipid droplet assembly factor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122853

    2. NM_001419291.1 → NP_001406220.1  lipid droplet assembly factor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122853

    3. NM_001419292.1 → NP_001406221.1  lipid droplet assembly factor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122853
      UniProtKB/Swiss-Prot
      Q8C5E0, Q922Z1
      Related
      ENSMUSP00000114085.2, ENSMUST00000118737.3

    4. NM_145586.2 → NP_663561.1  lipid droplet assembly factor 1 isoform 1

      See identical proteins and their annotated locations for NP_663561.1

      Status: VALIDATED

      Source sequence(s)
      AC122853
      Consensus CDS
      CCDS21791.1
      UniProtKB/Swiss-Prot
      Q8C5E0, Q922Z1
      Related
      ENSMUSP00000033210.6, ENSMUST00000033210.13
      Conserved Domains (1) summary
      pfam16015
      Location:41 → 128
      Promethin

    RNA

    1. NR_185056.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122853

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      119701599..119720212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922Z1.1 GenPept UniProtKB/Swiss-Prot:Q922Z1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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