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    Tbc1d17 TBC1 domain family, member 17 [ Mus musculus (house mouse) ]

    Gene ID: 233204, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tbc1d17provided by MGI
    Official Full Name
    TBC1 domain family, member 17provided by MGI
    Primary source
    MGI:MGI:2449973
    See related
    Ensembl:ENSMUSG00000038520 AllianceGenome:MGI:2449973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be located in autophagosome and recycling endosome. Predicted to be active in cytosol. Is expressed in central nervous system and retina. Orthologous to human TBC1D17 (TBC1 domain family member 17). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 47.1), ovary adult (RPKM 39.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tbc1d17 in Genome Data Viewer
    Location:
    7 B3; 7 28.93 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44490200..44498314, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44840776..44849079, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18814 Neighboring gene predicted gene, 29791 Neighboring gene STARR-seq mESC enhancer starr_18815 Neighboring gene STARR-seq mESC enhancer starr_18816 Neighboring gene STARR-positive B cell enhancer ABC_E1086 Neighboring gene activating transcription factor 5 Neighboring gene interleukin 4 induced 1B Neighboring gene nucleoporin 62 Neighboring gene STARR-positive B cell enhancer ABC_E9111 Neighboring gene interleukin 4 induced 1 Neighboring gene AKT1 substrate 1 Neighboring gene microRNA 707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52112565-52112765 Neighboring gene polynucleotide kinase 3'- phosphatase Neighboring gene prostate tumor over expressed gene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis. Chu CC, et al. Proc Natl Acad Sci U S A, 1997 Mar 18. PMID 9122225, Free PMC Article
    2. Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Chu CC, et al. Mol Immunol, 1998 Jun. PMID 9798653
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27642

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042655.2 → NP_001036120.1  TBC1 domain family member 17 isoform 1

      See identical proteins and their annotated locations for NP_001036120.1

      Status: VALIDATED

      Source sequence(s)
      AC158231
      Consensus CDS
      CCDS39944.1
      UniProtKB/Swiss-Prot
      Q3TCA5, Q8BYH7
      UniProtKB/TrEMBL
      Q3U5C0
      Related
      ENSMUSP00000048260.9, ENSMUST00000047085.16
      Conserved Domains (2) summary
      pfam12068
      Location:3 → 217
      DUF3548; Domain of unknown function (DUF3548)
      smart00164
      Location:307 → 542
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    2. NM_001420368.1 → NP_001407297.1  TBC1 domain family member 17 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158231

    3. NM_001420369.1 → NP_001407298.1  TBC1 domain family member 17 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC158231

    4. NM_001420370.1 → NP_001407299.1  TBC1 domain family member 17 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158231

    5. NM_001420371.1 → NP_001407300.1  TBC1 domain family member 17 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC158231

    6. NM_001420372.1 → NP_001407301.1  TBC1 domain family member 17 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC158231

    RNA

    1. NR_185164.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158231
      Related
      ENSMUST00000145959.8

    2. NR_185165.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158231

    3. NR_185166.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158231

    4. NR_185167.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158231

    5. NR_185168.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158231

    6. NR_185169.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158231

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44490200..44498314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144924.1: Suppressed sequence

      Description
      NM_144924.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BYH7.2 GenPept UniProtKB/Swiss-Prot:Q8BYH7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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