Oscar osteoclast associated receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oscarprovided by MGI
Official Full Name: osteoclast associated receptorprovided by MGI
Primary source: MGI:MGI:2179720
See related: Ensembl:ENSMUSG00000054594 AllianceGenome:MGI:2179720
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mOSCAR; mOSCAR-M1; mOSCAR-M2; mOSCAR-M3
Summary: Enables collagen receptor activity. Acts upstream of or within Fc-gamma receptor signaling pathway; multinuclear osteoclast differentiation; and positive regulation of bone resorption. Located in cell surface. Is expressed in testis. Orthologous to human OSCAR (osteoclast associated Ig-like receptor). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in frontal lobe adult (RPKM 1.4), testis adult (RPKM 1.4) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 2.08 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (3612812..3619156, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (3609813..3616157, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.
Title: Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation.
OSCAR expression in monocytic cells is regulated by proatherogenic stimuli further pointing towards a role in vascular inflammation or plaque vulnerability during atherosclerosis
Title: Monocytic expression of osteoclast-associated receptor (OSCAR) is induced in atherosclerotic mice and regulated by oxidized low-density lipoprotein in vitro.
Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice.
Title: OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.
Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL-mediated osteoclastogenesis.
Title: Upstream stimulatory factors regulate OSCAR gene expression in RANKL-mediated osteoclast differentiation.
OSCAR but not TREM-2 is involved in the positive feedback loop of the immunoreceptor-NFATc1 pathway during osteoclastogenesis
Title: Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis.
analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1, involving NFATc1-mediated OSCAR expression and its subsequent activation of NFATc1, necessary for efficient differentiation of osteoclasts
Title: Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis.
the FcRgamma-mediated signal transduction by OSCAR is involved in osteoclast differentiation
Title: Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR).
PU.1 and MITF transcription factors synergistically activate OSCAR gene expression, which is further enhanced by the TRANCE-induced MKK6/p38 signaling cascade.
Title: Microphthalmia transcription factor and PU.1 synergistically induce the leukocyte receptor osteoclast-associated receptor gene expression.
The overexpression of PIAS3 attenuates osteoclast formation and down-regulates the expression of NFATc1 and osteoclast-associated receptor (OSCAR), which are important modulators in osteoclastogenesis.
Title: Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables collagen receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables collagen receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Fc-gamma receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collagen-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within interleukin-2 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within interleukin-2 production	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within multinuclear osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within osteoclast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoclast differentiation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: osteoclast-associated immunoglobulin-like receptor

Names: ocl178; osteoclast-associated receptor OSCAR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290377.1 → NP_001277306.1 osteoclast-associated immunoglobulin-like receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_001277306.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AF391159, AF391160

Consensus CDS

CCDS71872.1

UniProtKB/Swiss-Prot

Q8VBT3, Q8VHT9

UniProtKB/TrEMBL

B2RQ61

Related

ENSMUSP00000104285.2, ENSMUST00000108645.8

Conserved Domains (1) summary

cl11960
Location:30 → 123

Ig; Immunoglobulin domain
NM_175632.3 → NP_783440.1 osteoclast-associated immunoglobulin-like receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_783440.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF391160, AF391161

Consensus CDS

CCDS20718.1

UniProtKB/TrEMBL

B2RQ61

Related

ENSMUSP00000041306.8, ENSMUST00000039507.15

Conserved Domains (1) summary

cl11960
Location:36 → 129

Ig; Immunoglobulin domain