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    Clec12a C-type lectin domain family 12, member a [ Mus musculus (house mouse) ]

    Gene ID: 232413, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Clec12aprovided by MGI
    Official Full Name
    C-type lectin domain family 12, member aprovided by MGI
    Primary source
    MGI:MGI:3040968
    See related
    Ensembl:ENSMUSG00000053063 AllianceGenome:MGI:3040968
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Micl; CLL-1; KLRL1; D230024O04
    Summary
    Predicted to enable protein phosphatase binding activity and transmembrane signaling receptor activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within regulation of immune response. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Is expressed in embryo mesenchyme; liver left lobe; liver right lobe; olfactory epithelium; and thymus primordium. Orthologous to human CLEC12A (C-type lectin domain family 12 member A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 6.7), liver E14 (RPKM 4.0) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Clec12a in Genome Data Viewer
    Location:
    6 F3; 6 63.26 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129327207..129342266)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129349783..129365303)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6497 Neighboring gene STARR-positive B cell enhancer ABC_E1329 Neighboring gene STARR-positive B cell enhancer ABC_E11735 Neighboring gene STARR-positive B cell enhancer ABC_E1330 Neighboring gene CD69 antigen Neighboring gene STARR-positive B cell enhancer ABC_E3684 Neighboring gene STARR-positive B cell enhancer ABC_E9103 Neighboring gene C-type lectin domain family 2, member m Neighboring gene STARR-seq mESC enhancer starr_17478 Neighboring gene STARR-seq mESC enhancer starr_17479 Neighboring gene STARR-positive B cell enhancer ABC_E6498 Neighboring gene C-type lectin domain family 12, member B Neighboring gene STARR-positive B cell enhancer ABC_E4872 Neighboring gene C-type lectin domain family 1, member b Neighboring gene C-type lectin domain family 9, member a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. mKLRL1 regulates the maturation of dendritic cells and plays important roles in immune tolerance. Liu G, et al. Am J Transl Res, 2019. PMID 30787988, Free PMC Article
    2. Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity. Sagar D, et al. Sci Rep, 2017 Jun 2. PMID 28578388, Free PMC Article
    3. MICL controls inflammation in rheumatoid arthritis. Redelinghuys P, et al. Ann Rheum Dis, 2016 Jul. PMID 26275430, Free PMC Article
    4. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Neumann K, et al. Immunity, 2014 Mar 20. PMID 24631154
    5. Mycobacterial mycolic acids trigger inhibitory receptor Clec12A to suppress host immune responses. Nishimura N, et al. Tuberculosis (Edinb), 2023 Jan. PMID 36542980

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recognition and control of neutrophil extracellular trap formation by MICL.
      Title: Recognition and control of neutrophil extracellular trap formation by MICL.
    2. Mycobacterial mycolic acids trigger inhibitory receptor Clec12A to suppress host immune responses.
      Title: Mycobacterial mycolic acids trigger inhibitory receptor Clec12A to suppress host immune responses.
    3. The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development.
      Title: The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development.
    4. Study observed that the uric acid crystal receptor Clec12A functions as a positive modulator of the IFN-I response, which amplifies nucleic acid-sensing pattern recognition receptors signals through the TBK1-IRF3 axis. Clec12a-/- mice exhibit increased susceptibility to acute lymphocytic choriomeningitis virus (LCMV) infection and improved virus clearance during chronic LCMV infection in vivo.
      Title: The uric acid crystal receptor Clec12A potentiates type I interferon responses.
    5. The effects of CLEC12A blocking were further validated using CLEC12A knockout (KO) animals wherein EAE disease induction was delayed and reduced disease severity was observed. These studies reveal the utility of a DC-specific mechanism in designing new therapeutics for MS.
      Title: Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity.
    6. Clec9A and Clec12A exhibit different intrinsic capacities to elicit MHC I and MHC II presentation following direct antigen targeting
      Title: Antibody-mediated targeting of antigen to C-type lectin-like receptors Clec9A and Clec12A elicits different vaccination outcomes.
    7. Clec12a(-/-) mice are more susceptible to Salmonella infection, supporting a role for CLEC12A in antibacterial defense pathways in vivo.
      Title: Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.
    8. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.
      Title: Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.
    9. CLL-1 expression is also present on the CD34(+)CD38(-) stem- cell compartment in acute myeloid leukemia
      Title: The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells.
    10. Anti-Clec12A mAb alone produced only moderate responses, but these were amplified by coinjecting only small amounts of LPS as a dendritic cell activation agent
      Title: The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (2)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pattern recognition receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pattern recognition receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables signaling receptor regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of dendritic cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of natural killer cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of natural killer cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neutrophil activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of neutrophil activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of type I interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-type lectin domain family 12 member A
    Names
    C-type lectin-like molecule 1
    myeloid inhibitory C-type lectin-like receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177686.4 → NP_808354.1  C-type lectin domain family 12 member A

      See identical proteins and their annotated locations for NP_808354.1

      Status: VALIDATED

      Source sequence(s)
      AC138620, AK084335, BB850261
      Consensus CDS
      CCDS20584.1
      UniProtKB/Swiss-Prot
      Q504P2, Q8BN96
      UniProtKB/TrEMBL
      A0A0R4J0T2
      Related
      ENSMUSP00000063627.5, ENSMUST00000065289.6
      Conserved Domains (1) summary
      cd03593
      Location:133 → 247
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      129327207..129342266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q504P2.1 GenPept UniProtKB/Swiss-Prot:Q504P2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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