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    Cdc14a CDC14 cell division cycle 14A [ Mus musculus (house mouse) ]

    Gene ID: 229776, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cdc14aprovided by MGI
    Official Full Name
    CDC14 cell division cycle 14Aprovided by MGI
    Primary source
    MGI:MGI:2442676
    See related
    Ensembl:ENSMUSG00000033502 AllianceGenome:MGI:2442676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdc14; CDC14A2; CDC14a1; A830059A17Rik
    Summary
    Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Involved in sensory perception of sound. Located in kinociliary basal body and stereocilium tip. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness 32. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to human CDC14A (cell division cycle 14A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 22.3), CNS E11.5 (RPKM 3.0) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdc14a in Genome Data Viewer
    Location:
    3 G1; 3 50.24 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (116066202..116222390, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (116272553..116428741, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08771 Neighboring gene G-protein coupled receptor 88 Neighboring gene predicted gene, 46839 Neighboring gene STARR-seq mESC enhancer starr_08772 Neighboring gene STARR-seq mESC enhancer starr_08773 Neighboring gene STARR-positive B cell enhancer ABC_E10208 Neighboring gene STARR-seq mESC enhancer starr_08775 Neighboring gene STARR-positive B cell enhancer ABC_E2097 Neighboring gene STARR-positive B cell enhancer ABC_E3463 Neighboring gene predicted gene, 40125 Neighboring gene predicted gene, 22361 Neighboring gene predicted gene, 26358

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells. Villarroya-Beltri C, et al. EMBO J, 2023 Jan 4. PMID 36326833, Free PMC Article
    2. The role of Cdc14 phosphatases in the control of cell division. Clifford DM, et al. Biochem Soc Trans, 2008 Jun. PMID 18481975
    3. Cdc14a has a role in spermatogenesis, sperm maturation and male fertility. Wen Z, et al. Exp Cell Res, 2020 Oct 1. PMID 32679235
    4. Phospho‑regulation of Cdc14A by polo‑like kinase 1 is involved in β‑cell function and cell cycle regulation. Hu H, et al. Mol Med Rep, 2019 Nov. PMID 31545409
    5. Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair. Lin H, et al. Mol Cell Biol, 2015 Nov. PMID 26283732, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells.
      Title: Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells.
    2. Cdc14a has a role in spermatogenesis, sperm maturation and male fertility.
      Title: Cdc14a has a role in spermatogenesis, sperm maturation and male fertility.
    3. PLK1 promoted cell proliferation and insulin secretion while inhibiting cellular apoptosis in betaTC3 cell lines under both low and high glucose conditions. In addition, the phosphoregulation of Cdc14A by PLK1 may be involved in betaTC3 cell cycle regulation and insulin secretion under high glucose conditions.
      Title: Phospho‑regulation of Cdc14A by polo‑like kinase 1 is involved in β‑cell function and cell cycle regulation.
    4. CDC14A activity is necessary for hearing and male fertility.
      Title: CDC14A phosphatase is essential for hearing and male fertility in mouse and human.
    5. Cdc14B knockout (Cdc14B(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low.
      Title: Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.
    6. CDC14A regulates oocyte maturation and functions to promote the meiosis I-to-meiosis II transition as its homolog does in budding yeast.
      Title: The CDC14A phosphatase regulates oocyte maturation in mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of exit from mitosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinociliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinocilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stereocilium tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual specificity protein phosphatase CDC14A
    Names
    CDC14 cell division cycle 14 homolog A
    NP_001074287.1
    NP_001167024.1
    NP_001342575.1
    NP_001365922.1
    NP_001365923.1
    XP_017175051.1
    XP_030108457.1
    XP_036018972.1
    XP_036018973.1
    XP_036018974.1
    XP_036018975.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080818.2 → NP_001074287.1  dual specificity protein phosphatase CDC14A isoform 1

      See identical proteins and their annotated locations for NP_001074287.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AK052560, AK142294, BC072644
      Consensus CDS
      CCDS38611.1
      UniProtKB/Swiss-Prot
      Q6GQT0, Q8BZ66
      Related
      ENSMUSP00000087950.5, ENSMUST00000090464.7
      Conserved Domains (3) summary
      COG2453
      Location:175 → 329
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:17 → 152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:187 → 326
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_001173553.2 → NP_001167024.1  dual specificity protein phosphatase CDC14A isoform 2

      See identical proteins and their annotated locations for NP_001167024.1

      Status: VALIDATED

      Source sequence(s)
      AK142294, BC072644
      Consensus CDS
      CCDS51058.1
      UniProtKB/Swiss-Prot
      Q6GQT0
      Related
      ENSMUSP00000102100.3, ENSMUST00000106491.7
      Conserved Domains (3) summary
      COG2453
      Location:126 → 280
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:17 → 108
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:138 → 277
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    3. NM_001355646.1 → NP_001342575.1  dual specificity protein phosphatase CDC14A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC165364, BC072644
      Conserved Domains (1) summary
      cl28904
      Location:1 → 43
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. NM_001378993.1 → NP_001365922.1  dual specificity protein phosphatase CDC14A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC165364
      Conserved Domains (2) summary
      cd14499
      Location:163 → 336
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:10 → 154
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    5. NM_001378994.1 → NP_001365923.1  dual specificity protein phosphatase CDC14A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC165364
      UniProtKB/TrEMBL
      A0A5F8MPZ4
      Related
      ENSMUSP00000159189.2, ENSMUST00000239145.2
      Conserved Domains (2) summary
      cd14499
      Location:105 → 278
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:1 → 96
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      116066202..116222390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163080.1 → XP_036018973.1  dual specificity protein phosphatase CDC14A isoform X2

      Conserved Domains (2) summary
      cd14499
      Location:178 → 351
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:10 → 169
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    2. XM_036163082.1 → XP_036018975.1  dual specificity protein phosphatase CDC14A isoform X4

      Conserved Domains (1) summary
      cl28904
      Location:1 → 43
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    3. XM_036163079.1 → XP_036018972.1  dual specificity protein phosphatase CDC14A isoform X1

      Conserved Domains (2) summary
      cd14499
      Location:178 → 351
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:10 → 169
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    4. XM_036163081.1 → XP_036018974.1  dual specificity protein phosphatase CDC14A isoform X3

      Conserved Domains (1) summary
      cl28904
      Location:1 → 43
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    5. XM_030252597.2 → XP_030108457.1  dual specificity protein phosphatase CDC14A isoform X3

      Conserved Domains (1) summary
      cl28904
      Location:1 → 43
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    6. XM_017319562.3 → XP_017175051.1  dual specificity protein phosphatase CDC14A isoform X3

      Conserved Domains (1) summary
      cl28904
      Location:1 → 43
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RNA

    1. XR_004941316.1 RNA Sequence

    2. XR_004941317.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GQT0.2 GenPept UniProtKB/Swiss-Prot:Q6GQT0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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