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    Zfp13 zinc finger protein 13 [ Mus musculus (house mouse) ]

    Gene ID: 22654, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp13provided by MGI
    Official Full Name
    zinc finger protein 13provided by MGI
    Primary source
    MGI:MGI:99159
    See related
    Ensembl:ENSMUSG00000062012 AllianceGenome:MGI:99159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Krox-8; Zfp-13
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleus. Is expressed in several structures, including early conceptus; eye; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human ZNF205 (zinc finger protein 205). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 18.2), ovary adult (RPKM 12.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp13 in Genome Data Viewer
    Location:
    17 A3.3; 17 11.72 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23788820..23818729, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23569846..23599755, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330415G19 gene Neighboring gene caspase 16, apoptosis-related cysteine peptidase Neighboring gene zinc finger protein 213 Neighboring gene STARR-positive B cell enhancer ABC_E9944 Neighboring gene STARR-seq mESC enhancer starr_42052 Neighboring gene STARR-seq mESC enhancer starr_42053 Neighboring gene STARR-seq mESC enhancer starr_42054 Neighboring gene zinc finger and SCAN domain containing 10 Neighboring gene calcium binding protein 39-like pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel transcriptional repressor, Rhit, is involved in heat-inducible and age-dependent expression of Mpv17-like protein, a participant in reactive oxygen species metabolism. Iida R, et al. Mol Cell Biol, 2010 May. PMID 20231359, Free PMC Article
    2. Characterization of a mouse multigene family that encodes zinc finger structures. Chavrier P, et al. Mol Cell Biol, 1988 Mar. PMID 2452975, Free PMC Article
    3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that Rhit acts as a repressor in the heat-induced and age-dependent transcriptional regulation of the (S) isoform of Mpv17-like protein.
      Title: A novel transcriptional repressor, Rhit, is involved in heat-inducible and age-dependent expression of Mpv17-like protein, a participant in reactive oxygen species metabolism.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of hydrogen peroxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of hydrogen peroxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional repressor Rhit
    Names
    zinc finger protein Krox-8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356268.2 → NP_001343197.1  transcriptional repressor Rhit isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154766
      Consensus CDS
      CCDS89003.1
      UniProtKB/Swiss-Prot
      D7F2B3, P10754, Q80WS0, Q8CDD0
      Related
      ENSMUSP00000111178.4, ENSMUST00000115516.11
      Conserved Domains (4) summary
      COG5048
      Location:326 → 486
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380 → 400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:123 → 154
      KRAB; KRAB box
      pfam13465
      Location:280 → 305
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001414203.1 → NP_001401132.1  transcriptional repressor Rhit isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154766

    3. NM_001414204.1 → NP_001401133.1  transcriptional repressor Rhit isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154766

    4. NM_001414205.1 → NP_001401134.1  transcriptional repressor Rhit isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154766

    5. NM_001414207.1 → NP_001401136.1  transcriptional repressor Rhit isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154766

    6. NM_001414208.1 → NP_001401137.1  transcriptional repressor Rhit isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC154766

    7. NM_001414209.1 → NP_001401138.1  transcriptional repressor Rhit isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC154766

    8. NM_001414210.1 → NP_001401139.1  transcriptional repressor Rhit isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154766

    9. NM_001414211.1 → NP_001401140.1  transcriptional repressor Rhit isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC154766

    10. NM_001414212.1 → NP_001401141.1  transcriptional repressor Rhit isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154766
      UniProtKB/Swiss-Prot
      D7F2B3, P10754, Q80WS0, Q8CDD0

    11. NM_011747.4 → NP_035877.1  transcriptional repressor Rhit isoform 1

      See identical proteins and their annotated locations for NP_035877.1

      Status: VALIDATED

      Source sequence(s)
      AC154766
      Consensus CDS
      CCDS28450.1
      UniProtKB/Swiss-Prot
      P10754
      Related
      ENSMUSP00000054595.5, ENSMUST00000057029.5
      Conserved Domains (4) summary
      COG5048
      Location:319 → 479
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:373 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:116 → 147
      KRAB; KRAB box
      pfam13465
      Location:273 → 298
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_182255.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154766

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      23788820..23818729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246423.3 → XP_011244725.1  transcriptional repressor Rhit isoform X2

      See identical proteins and their annotated locations for XP_011244725.1

      Conserved Domains (4) summary
      smart00349
      Location:117 → 172
      KRAB; krueppel associated box
      COG5048
      Location:353 → 513
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:407 → 427
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:307 → 332
      zf-H2C2_2; Zinc-finger double domain

    2. XM_030249750.1 → XP_030105610.1  transcriptional repressor Rhit isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:336 → 496
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:390 → 410
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:116 → 147
      KRAB; KRAB box
      pfam13465
      Location:290 → 315
      zf-H2C2_2; Zinc-finger double domain

    3. XM_011246421.3 → XP_011244723.1  transcriptional repressor Rhit isoform X1

      See identical proteins and their annotated locations for XP_011244723.1

      Conserved Domains (4) summary
      smart00349
      Location:124 → 179
      KRAB; krueppel associated box
      COG5048
      Location:360 → 520
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:414 → 434
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:314 → 339
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10754.2 GenPept UniProtKB/Swiss-Prot:P10754

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