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    Prlhr prolactin releasing hormone receptor [ Mus musculus (house mouse) ]

    Gene ID: 226278, updated on 18-Sep-2024

    Summary

    Official Symbol
    Prlhrprovided by MGI
    Official Full Name
    prolactin releasing hormone receptorprovided by MGI
    Primary source
    MGI:MGI:2135956
    See related
    Ensembl:ENSMUSG00000045052 AllianceGenome:MGI:2135956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gr3; Gm339; Gpr10; Prrpr
    Summary
    Enables G protein-coupled receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway; feeding behavior; and hormone metabolic process. Predicted to be located in cilium. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human PRLHR (prolactin releasing hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Prlhr in Genome Data Viewer
    Location:
    19 D3; 19 56.52 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (60454079..60457907, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (60465641..60468933, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr19:60386552-60386852 Neighboring gene predicted gene, 41882 Neighboring gene predicted gene, 34300 Neighboring gene CDK2 associated, cullin domain 1 Neighboring gene predicted gene, 41884 Neighboring gene STARR-seq mESC enhancer starr_46598 Neighboring gene STARR-positive B cell enhancer ABC_E3256 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60684594-60684894 Neighboring gene STARR-seq mESC enhancer starr_46599 Neighboring gene predicted gene, 46652

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neuropeptide Y receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    prolactin-releasing peptide receptor
    Names
    G-protein coupled receptor 10
    PrRP receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201615.2NP_963909.2  prolactin-releasing peptide receptor

      See identical proteins and their annotated locations for NP_963909.2

      Status: VALIDATED

      Source sequence(s)
      AC167713
      Consensus CDS
      CCDS29940.1
      UniProtKB/Swiss-Prot
      E9QJU3, Q059H6, Q6VMN6
      Related
      ENSMUSP00000063114.3, ENSMUST00000051277.4
      Conserved Domains (1) summary
      cd15394
      Location:61346
      7tmA_PrRP_R; prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      60454079..60457907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527057.4XP_006527120.1  prolactin-releasing peptide receptor isoform X1

      See identical proteins and their annotated locations for XP_006527120.1

      UniProtKB/Swiss-Prot
      E9QJU3, Q059H6, Q6VMN6
      Conserved Domains (1) summary
      cd15394
      Location:61346
      7tmA_PrRP_R; prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors