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    Pprc1 peroxisome proliferative activated receptor, gamma, coactivator-related 1 [ Mus musculus (house mouse) ]

    Gene ID: 226169, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pprc1provided by MGI
    Official Full Name
    peroxisome proliferative activated receptor, gamma, coactivator-related 1provided by MGI
    Primary source
    MGI:MGI:2385096
    See related
    Ensembl:ENSMUSG00000055491 AllianceGenome:MGI:2385096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PRC; mKIAA0595; A930018M19
    Summary
    Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in energy homeostasis and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; limb; and sensory organ. Orthologous to human PPRC1 (PPARG related coactivator 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 14.9), ovary adult (RPKM 11.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pprc1 in Genome Data Viewer
    Location:
    19 C3; 19 38.75 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46044955..46061348)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46056526..46072909)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930505N22 gene Neighboring gene HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene STARR-seq mESC enhancer starr_46294 Neighboring gene STARR-positive B cell enhancer ABC_E5707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46114769-46114954 Neighboring gene LIM domain binding 1 Neighboring gene STARR-positive B cell enhancer ABC_E1527 Neighboring gene STARR-positive B cell enhancer ABC_E7666 Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired-like homeodomain transcription factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Resistance to high-fat diet-induced obesity in male heterozygous Pprc1 knockout mice. Zhai N, et al. Endocr J, 2015. PMID 25994039
    2. Peri-implantation lethality in mice lacking the PGC-1-related coactivator protein. He X, et al. Dev Dyn, 2012 May. PMID 22411706
    3. Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria. Vercauteren K, et al. J Biol Chem, 2009 Jan 23. PMID 19036724, Free PMC Article
    4. New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond. Villena JA. FEBS J, 2015 Feb. PMID 25495651
    5. Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice. Alkaissi H, et al. Environ Health Perspect, 2016 Jul. PMID 26942574, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC12121

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in energy homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peroxisome proliferator-activated receptor gamma coactivator-related protein 1
    Names
    PGC-1-related coactivator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081214.1 → NP_001074683.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001074683.1

      Status: VALIDATED

      Source sequence(s)
      AC140233
      Consensus CDS
      CCDS38005.1
      UniProtKB/Swiss-Prot
      Q3UGG3, Q6NZN1, Q80TW6, Q8BXP6, Q91YW8
      Related
      ENSMUSP00000107530.2, ENSMUST00000111899.8
      Conserved Domains (1) summary
      cd12624
      Location:1521 → 1611
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    2. NM_001346801.1 → NP_001333730.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140233
      Consensus CDS
      CCDS89404.1
      UniProtKB/Swiss-Prot
      Q6NZN1
      Related
      ENSMUSP00000079389.4, ENSMUST00000062322.11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      46044955..46061348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527008.4 → XP_006527071.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:582 → 1120
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1521 → 1611
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    2. XM_030250903.2 → XP_030106763.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

      Conserved Domains (2) summary
      PHA03247
      Location:988 → 1383
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1520 → 1610
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    3. XM_006527009.4 → XP_006527072.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X4

      Conserved Domains (2) summary
      PHA03247
      Location:579 → 1117
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1520 → 1610
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    4. XM_006527007.4 → XP_006527070.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:581 → 1119
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1522 → 1612
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    5. XM_030250902.2 → XP_030106762.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X5

      Conserved Domains (2) summary
      PHA03247
      Location:581 → 1119
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1520 → 1610
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    6. XM_030250905.2 → XP_030106765.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X8

      Conserved Domains (2) summary
      PHA03247
      Location:987 → 1382
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1519 → 1609
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    7. XM_011247239.3 → XP_011245541.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

      Conserved Domains (2) summary
      PHA03247
      Location:578 → 1116
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1519 → 1609
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    8. XM_030250906.2 → XP_030106766.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X9

      Conserved Domains (2) summary
      PHA03247
      Location:984 → 1379
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1518 → 1608
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    9. XM_036161570.1 → XP_036017463.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X12

      Conserved Domains (2) summary
      PHA03247
      Location:984 → 1379
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1516 → 1606
      RRM_PRC; RNA recognition motif (RRM) found in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    10. XM_017318166.3 → XP_017173655.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q6NZN1
      Conserved Domains (2) summary
      PHA03247
      Location:988 → 1383
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1522 → 1612
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    11. XM_006527010.3 → XP_006527073.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X10

      Conserved Domains (2) summary
      PHA03247
      Location:576 → 1114
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1517 → 1607
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    12. XM_006527011.3 → XP_006527074.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X11

      Conserved Domains (2) summary
      PHA03247
      Location:575 → 1113
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1516 → 1606
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    13. XM_011247240.4 → XP_011245542.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X13

      Conserved Domains (2) summary
      PHA03247
      Location:535 → 1073
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1476 → 1566
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    14. XM_011247241.2 → XP_011245543.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X14

      Conserved Domains (2) summary
      PHA03247
      Location:466 → 1004
      PHA03247; large tegument protein UL36; Provisional
      cd12624
      Location:1405 → 1495
      RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145504.1: Suppressed sequence

      Description
      NM_145504.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NZN1.1 GenPept UniProtKB/Swiss-Prot:Q6NZN1

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