Stk24 serine/threonine kinase 24 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stk24provided by MGI
Official Full Name: serine/threonine kinase 24provided by MGI
Primary source: MGI:MGI:2385007
See related: Ensembl:ENSMUSG00000063410 AllianceGenome:MGI:2385007
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mst3; MST-3; STE20; 1810013H02Rik
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of axon regeneration; and protein autophosphorylation. Predicted to be located in Golgi membrane; cytosol; and nucleolus. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in Golgi apparatus. Is expressed in central nervous system and neural retina. Orthologous to human STK24 (serine/threonine kinase 24). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 21.9), large intestine adult (RPKM 15.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E5; 14 64.95 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (121521599..121618269, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (121284187..121380496, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT-PD-L1 Axis.
Title: Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT-PD-L1 Axis.
Epithelial polarization in the 3D matrix requires MST3 signaling to regulate ZO-1 position.
Title: Epithelial polarization in the 3D matrix requires MST3 signaling to regulate ZO-1 position.
Sterile 20-like kinase 3 promotes tick-borne encephalitis virus assembly by interacting with NS2A and prM and enhancing the NS2A-NS4A association.
Title: Sterile 20-like kinase 3 promotes tick-borne encephalitis virus assembly by interacting with NS2A and prM and enhancing the NS2A-NS4A association.
Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation.
Title: Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation.
Biochemical purification uncovers mammalian sterile 3 (MST3) as a new protein kinase for multifunctional protein kinases AMPK and SIK3.
Title: Biochemical purification uncovers mammalian sterile 3 (MST3) as a new protein kinase for multifunctional protein kinases AMPK and SIK3.
GCKIII (Germinal Center Kinase III) Kinases STK24 and STK25 (Serine/Threonine Kinase 24 and 25) Inhibit Cavernoma Development.
Title: GCKIII (Germinal Center Kinase III) Kinases STK24 and STK25 (Serine/Threonine Kinase 24 and 25) Inhibit Cavernoma Development.
STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.
Title: STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.
MST3 Involvement in Na(+) and K(+) Homeostasis with Increasing Dietary Potassium Intake.
Title: MST3 Involvement in Na(+) and K(+) Homeostasis with Increasing Dietary Potassium Intake.
MST3 protein coats lipid droplets in mouse liver cells from mice fed a high-fat diet. MST3 fully colocalized with ADRP, the main LD-coating protein in mouse liver. No MST3 protein was detected in the cytosolic fraction. High mRNA and protein expression of MST3 was also found in organs that do not accumulate significant amounts of intracellular LDs.
Title: Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in humans.
results indicated that serine/threonine kinase 24 (MST3) maintained Na(+) homeostasis through epithelial Na(+) channel( ENaC) regulation
Title: MST3 is involved in ENaC-mediated hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:493334 (e-PCR)
- UniSTS:493334

RH48488 (e-PCR)
- UniSTS:57654

RH125984 (e-PCR)
- UniSTS:162696

Stk24 (e-PCR), detects polymorphism
- UniSTS:527568

RH124930 (e-PCR)
- UniSTS:161752

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in execution phase of apoptosis	IEA Inferred from Electronic Annotation more info
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of axon regeneration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of axon regeneration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	ISO Inferred from Sequence Orthology more info
part_of FAR/SIN/STRIPAK complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein kinase 24

Names: STE20-like kinase MST3; mammalian STE20-like protein kinase 3; mammalian sterile twenty 3 kinase; serine/threonine kinase 24 (STE20 homolog, yeast)

NP_663440.1

EC 2.7.11.1

XP_006518981.1

EC 2.7.11.1

XP_011243345.1

EC 2.7.11.1

XP_017171477.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145465.2 → NP_663440.1 serine/threonine-protein kinase 24

See identical proteins and their annotated locations for NP_663440.1

Status: VALIDATED

Source sequence(s)

AK154959, BE687884, BY730101

Consensus CDS

CCDS37016.1

UniProtKB/Swiss-Prot

Q99KH8

UniProtKB/TrEMBL

Q3U335, Q3U3T6

Related

ENSMUSP00000078746.8, ENSMUST00000079817.8

Conserved Domains (2) summary

smart00220
Location:24 → 274

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06609
Location:22 → 295

STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

121521599..121618269 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518918.3 → XP_006518981.1 serine/threonine-protein kinase 24 isoform X3

Conserved Domains (1) summary

cl21453
Location:1 → 197

PKc_like; Protein Kinases, catalytic domain
XM_011245043.4 → XP_011243345.1 serine/threonine-protein kinase 24 isoform X2

UniProtKB/TrEMBL

Q3U3T6

Conserved Domains (1) summary

cd06609
Location:21 → 294

STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
XM_017315988.2 → XP_017171477.1 serine/threonine-protein kinase 24 isoform X1

UniProtKB/TrEMBL

Q3U3T6

Conserved Domains (1) summary

cd06609
Location:34 → 307

STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases