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    Nr2c2 nuclear receptor subfamily 2, group C, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 22026, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nr2c2provided by MGI
    Official Full Name
    nuclear receptor subfamily 2, group C, member 2provided by MGI
    Primary source
    MGI:MGI:1352466
    See related
    Ensembl:ENSMUSG00000005893 AllianceGenome:MGI:1352466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tr4; TAK1; mKIAA4145
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Involved in several processes, including p38MAPK cascade; positive regulation of embryonic development; and positive regulation of myoblast differentiation. Acts upstream of or within lipopolysaccharide-mediated signaling pathway; meiotic cell cycle; and spermatogenesis. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human NR2C2 (nuclear receptor subfamily 2 group C member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 13.2), thymus adult (RPKM 12.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nr2c2 in Genome Data Viewer
    Location:
    6 D1; 6 41.03 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (92068426..92150039)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (92091418..92173058)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53299 Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E539 Neighboring gene predicted gene, 46967 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene rabenosyn, RAB effector Neighboring gene STARR-seq mESC enhancer starr_16664 Neighboring gene thyrotropin releasing hormone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning of the gene encoding the murine orphan receptor TAK1 and cell-type-specific expression in testis. Hirose T, et al. Gene, 1995 Oct 3. PMID 7590273
    2. TAK1 regulates Paneth cell integrity partly through blocking necroptosis. Simmons AN, et al. Cell Death Dis, 2016 Apr 14. PMID 27077812, Free PMC Article
    3. The role of TGF-β-activated kinase 1 in db/db mice and high glucose-induced macrophage. Xu X, et al. Int Immunopharmacol, 2016 Sep. PMID 27268284
    4. False responses of Renilla luciferase reporter control to nuclear receptor TR4. Zhang D, et al. Mol Cell Biochem, 2017 Jun. PMID 28210900
    5. Deficiency in TR4 nuclear receptor abrogates Gadd45a expression and increases cytotoxicity induced by ionizing radiation. Yan SJ, et al. Cell Mol Biol Lett, 2012 Jun. PMID 22396141, Free PMC Article

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Roquin-2 promotes oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1.
      Title: Roquin-2 promotes oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1.
    2. Mycobacterium tuberculosis Rv1043c regulates the inflammatory response by inhibiting the phosphorylation of TAK1.
      Title: Mycobacterium tuberculosis Rv1043c regulates the inflammatory response by inhibiting the phosphorylation of TAK1.
    3. Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis.
      Title: Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis.
    4. TR4 worsen urosepsis by regulating GSDMD.
      Title: TR4 worsen urosepsis by regulating GSDMD.
    5. TAK1 is an essential kinase for STING trafficking.
      Title: TAK1 is an essential kinase for STING trafficking.
    6. Small molecule activators of TAK1 promotes its activity-dependent ubiquitination and TRAIL-mediated tumor cell death.
      Title: Small molecule activators of TAK1 promotes its activity-dependent ubiquitination and TRAIL-mediated tumor cell death.
    7. Transforming Growth Factor-beta-Activated Kinase 1 (TAK1) Mediates Chronic Pain and Cytokine Production in Mouse Models of Inflammatory, Neuropathic, and Primary Pain.
      Title: Transforming Growth Factor-β-Activated Kinase 1 (TAK1) Mediates Chronic Pain and Cytokine Production in Mouse Models of Inflammatory, Neuropathic, and Primary Pain.
    8. p-TAK1 acts as a switch between myoblast proliferation phase and differentiation phase in mdx mice via regulating HO-1 expression.
      Title: p-TAK1 acts as a switch between myoblast proliferation phase and differentiation phase in mdx mice via regulating HO-1 expression.
    9. Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection.
      Title: Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection.
    10. Gonadal hormone trigger the dynamic microglial alterations through Traf6/TAK1 axis that correlate with depressive behaviors.
      Title: Gonadal hormone trigger the dynamic microglial alterations through Traf6/TAK1 axis that correlate with depressive behaviors.
    Submit: New GeneRIF Correction See all GeneRIFs (69)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (9)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4145, MGC124356, MGC124357, MGC124358

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebellum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in p38MAPK cascade IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of embryonic development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor subfamily 2 group C member 2
    Names
    nuclear receptor subfamily 2, group H, member 2
    orphan nuclear receptor TAK1
    orphan nuclear receptor TR4
    orphan receptor, TR4
    testicular receptor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347342.2 → NP_001334271.1  nuclear receptor subfamily 2 group C member 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AC121593, AC164642
      Consensus CDS
      CCDS85096.1
      UniProtKB/TrEMBL
      G3X9W4, Q3U015
      Related
      ENSMUSP00000109090.2, ENSMUST00000113463.8
      Conserved Domains (2) summary
      cd06952
      Location:394 → 615
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:145 → 231
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    2. NM_001410478.1 → NP_001397407.1  nuclear receptor subfamily 2 group C member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121593, AC164642
      UniProtKB/TrEMBL
      G3X9W4

    3. NM_001410479.1 → NP_001397408.1  nuclear receptor subfamily 2 group C member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121593, AC164642
      UniProtKB/Swiss-Prot
      P49117, P55093
      UniProtKB/TrEMBL
      Q3ZAS1

    4. NM_001410480.1 → NP_001397409.1  nuclear receptor subfamily 2 group C member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121593, AC164642
      UniProtKB/Swiss-Prot
      P49117, P55093
      UniProtKB/TrEMBL
      Q3ZAS1
      Related
      ENSMUSP00000138465.2, ENSMUST00000146175.2

    5. NM_001410481.1 → NP_001397410.1  nuclear receptor subfamily 2 group C member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121593, AC164642
      UniProtKB/Swiss-Prot
      P49117, P55093
      UniProtKB/TrEMBL
      Q3ZAS1

    6. NM_001410482.1 → NP_001397411.1  nuclear receptor subfamily 2 group C member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121593, AC164642
      UniProtKB/Swiss-Prot
      P49117, P55093
      UniProtKB/TrEMBL
      Q3ZAS1

    7. NM_001410483.1 → NP_001397412.1  nuclear receptor subfamily 2 group C member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121593, AC164642

    8. NM_001410484.1 → NP_001397413.1  nuclear receptor subfamily 2 group C member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121593, AC164642

    9. NM_001410485.1 → NP_001397414.1  nuclear receptor subfamily 2 group C member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121593, AC164642

    10. NM_011630.4 → NP_035760.1  nuclear receptor subfamily 2 group C member 2 isoform 2

      See identical proteins and their annotated locations for NP_035760.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 4-7 all encode the same isoform (2).
      Source sequence(s)
      AC121593, AC164642
      Consensus CDS
      CCDS20372.1
      UniProtKB/Swiss-Prot
      P49117, P55093
      UniProtKB/TrEMBL
      Q3U015, Q3ZAS1
      Related
      ENSMUSP00000109087.2, ENSMUST00000113460.8
      Conserved Domains (2) summary
      cd06952
      Location:361 → 582
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cd06967
      Location:112 → 198
      NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      92068426..92150039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321518.1 → XP_017177007.1  nuclear receptor subfamily 2 group C member 2 isoform X3

      UniProtKB/TrEMBL
      Q5DTL3
      Conserved Domains (2) summary
      cd06952
      Location:182 → 403
      NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
      cl02596
      Location:1 → 19
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49117.1 GenPept UniProtKB/Swiss-Prot:P49117

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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