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    Top3b topoisomerase (DNA) III beta [ Mus musculus (house mouse) ]

    Gene ID: 21976, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Top3bprovided by MGI
    Official Full Name
    topoisomerase (DNA) III betaprovided by MGI
    Primary source
    MGI:MGI:1333803
    See related
    Ensembl:ENSMUSG00000022779 AllianceGenome:MGI:1333803
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Acts upstream of or within chromosome segregation. Located in condensed chromosome. Is expressed in liver. Orthologous to human TOP3B (DNA topoisomerase III beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 15.8), kidney adult (RPKM 15.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 A3; 16 10.46 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16688587..16710850)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (16870722..16892986)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40238 Neighboring gene immunoglobulin lambda-like polypeptide 1 Neighboring gene V-set pre-B cell surrogate light chain 1A Neighboring gene STARR-positive B cell enhancer mm9_chr16:16896457-16896758 Neighboring gene protein phosphatase 1F (PP2C domain containing) Neighboring gene STARR-seq mESC enhancer starr_40239 Neighboring gene 28S ribosomal protein S21, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA topoisomerase Top3beta is impacted by early life stress in the developing female and male rat brain.
      Title: DNA topoisomerase Top3β is impacted by early life stress in the developing female and male rat brain.
    2. Topoisomerase IIIbeta Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice.
      Title: Topoisomerase IIIβ Deficiency Induces Neuro-Behavioral Changes and Brain Connectivity Alterations in Mice.
    3. Topoisomerase 3beta knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity.
      Title: Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity.
    4. This study indicated a role for TOP3beta in mRNA metabolism and suggest that it is involved in neurodevelopmental disorders.
      Title: Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders.
    5. suggest an unanticipated role for Top3beta beyond DNA repair in the activation of cellular responses to DNA damage
      Title: Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta.
    6. DNA topoisomerase III beta has a role in infertility and aneuploidy
      Title: Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta.
    7. Chromosomal abnormalities in top3beta(-/-) mice might lead to a persistent increase in apoptotic cells, which might in turn lead to the progression of autoimmunity
      Title: Development of autoimmunity in mice lacking DNA topoisomerase 3beta.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA topoisomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA topological change IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA topological change NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA topoisomerase III-beta-TDRD3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of DNA topoisomerase III-beta-TDRD3 complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA topoisomerase 3-beta-1
    Names
    DNA topoisomerase III beta-1
    Topo III beta
    NP_001313505.1
    NP_035754.1
    XP_006522054.1
    XP_006522055.1
    XP_006522057.1
    XP_006522058.1
    XP_006522060.1
    XP_017172426.1
    XP_030104903.1
    XP_030104904.1
    XP_030104905.1
    XP_036015766.1
    XP_036015767.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326576.1 → NP_001313505.1  DNA topoisomerase 3-beta-1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC166832, AK144709, AW122701
      Consensus CDS
      CCDS27990.1
      UniProtKB/Swiss-Prot
      Q9Z321
      UniProtKB/TrEMBL
      Q3UJF5
      Related
      ENSMUSP00000156132.2, ENSMUST00000232581.2
      Conserved Domains (2) summary
      cd03362
      Location:3 → 167
      TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
      pfam01131
      Location:169 → 582
      Topoisom_bac; DNA topoisomerase

    2. NM_011624.3 → NP_035754.1  DNA topoisomerase 3-beta-1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC166832, AK146475, AW122701, BY035336
      Consensus CDS
      CCDS27990.1
      UniProtKB/Swiss-Prot
      Q9Z321
      UniProtKB/TrEMBL
      Q3UJF5
      Related
      ENSMUSP00000023465.8, ENSMUST00000023465.16
      Conserved Domains (2) summary
      cd03362
      Location:3 → 167
      TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
      pfam01131
      Location:169 → 582
      Topoisom_bac; DNA topoisomerase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      16688587..16710850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249043.2 → XP_030104903.1  DNA topoisomerase 3-beta-1 isoform X2

      Conserved Domains (2) summary
      pfam01131
      Location:72 → 485
      Topoisom_bac; DNA topoisomerase
      cl00718
      Location:1 → 70
      TOPRIM; Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...

    2. XM_006521991.5 → XP_006522054.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z321
      UniProtKB/TrEMBL
      Q3UJF5
      Conserved Domains (2) summary
      cd03362
      Location:3 → 167
      TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
      pfam01131
      Location:169 → 582
      Topoisom_bac; DNA topoisomerase

    3. XM_006521997.4 → XP_006522060.1  DNA topoisomerase 3-beta-1 isoform X3

      Conserved Domains (2) summary
      cd03362
      Location:3 → 167
      TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
      pfam01131
      Location:169 → 582
      Topoisom_bac; DNA topoisomerase

    4. XM_006521992.5 → XP_006522055.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z321
      UniProtKB/TrEMBL
      Q3UJF5
      Conserved Domains (2) summary
      cd03362
      Location:3 → 167
      TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
      pfam01131
      Location:169 → 582
      Topoisom_bac; DNA topoisomerase

    5. XM_030249045.2 → XP_030104905.1  DNA topoisomerase 3-beta-1 isoform X2

      Conserved Domains (2) summary
      pfam01131
      Location:72 → 485
      Topoisom_bac; DNA topoisomerase
      cl00718
      Location:1 → 70
      TOPRIM; Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...

    6. XM_030249044.2 → XP_030104904.1  DNA topoisomerase 3-beta-1 isoform X2

      Conserved Domains (2) summary
      pfam01131
      Location:72 → 485
      Topoisom_bac; DNA topoisomerase
      cl00718
      Location:1 → 70
      TOPRIM; Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...

    7. XM_036159873.1 → XP_036015766.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z321
      UniProtKB/TrEMBL
      Q3UJF5
      Conserved Domains (2) summary
      cd03362
      Location:3 → 167
      TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
      pfam01131
      Location:169 → 582
      Topoisom_bac; DNA topoisomerase

    8. XM_006521994.4 → XP_006522057.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z321
      UniProtKB/TrEMBL
      Q3UJF5
      Conserved Domains (2) summary
      cd03362
      Location:3 → 167
      TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
      pfam01131
      Location:169 → 582
      Topoisom_bac; DNA topoisomerase

    9. XM_036159874.1 → XP_036015767.1  DNA topoisomerase 3-beta-1 isoform X4

      Conserved Domains (1) summary
      cd00186
      Location:10 → 322
      TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...

    10. XM_006521995.4 → XP_006522058.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z321
      UniProtKB/TrEMBL
      Q3UJF5
      Conserved Domains (2) summary
      cd03362
      Location:3 → 167
      TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
      pfam01131
      Location:169 → 582
      Topoisom_bac; DNA topoisomerase

    11. XM_017316937.3 → XP_017172426.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z321
      UniProtKB/TrEMBL
      Q3UJF5
      Conserved Domains (2) summary
      cd03362
      Location:3 → 167
      TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
      pfam01131
      Location:169 → 582
      Topoisom_bac; DNA topoisomerase

    RNA

    1. XR_001781810.3 RNA Sequence

    2. XR_003951778.2 RNA Sequence

      Related
      ENSMUST00000231278.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z321.1 GenPept UniProtKB/Swiss-Prot:Q9Z321

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