Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfsf11provided by MGI
Official Full Name: tumor necrosis factor (ligand) superfamily, member 11provided by MGI
Primary source: MGI:MGI:1100089
See related: Ensembl:ENSMUSG00000022015 AllianceGenome:MGI:1100089
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ODF; OPGL; RANKL; Ly109l; Trance
Summary: Enables identical protein binding activity; receptor ligand activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including intracellular signaling cassette; positive regulation of secretion by cell; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including cellular response to cytokine stimulus; mammary gland development; and positive regulation of intracellular signal transduction. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in extracellular space. Is expressed in bone; genitourinary system; hemolymphoid system; incisor; and rib. Used to study autosomal recessive osteopetrosis 2 and osteoporosis. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 2 and osteoporosis. Orthologous to human TNFSF11 (TNF superfamily member 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 1.0), mammary gland adult (RPKM 0.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 41.26 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (78514886..78545483, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (78277446..78308043, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microbial chaperonin 60 inhibits osteoclast differentiation by interfering with RANK/RANKL binding and overexpression of lipocalin2.
Title: Microbial chaperonin 60 inhibits osteoclast differentiation by interfering with RANK/RANKL binding and overexpression of lipocalin2.
14-3-3zeta suppresses RANKL signaling by destabilizing TRAF6.
Title: 14-3-3ζ suppresses RANKL signaling by destabilizing TRAF6.
Rankl genetic deficiency and functional blockade undermine skeletal stem and progenitor cell differentiation.
Title: Rankl genetic deficiency and functional blockade undermine skeletal stem and progenitor cell differentiation.
Characterization of a spontaneous osteopetrosis model using RANKL-dysfunctional mice.
Title: Characterization of a spontaneous osteopetrosis model using RANKL-dysfunctional mice.
Ctdnep1 phosphatase is required for negative regulation of RANKL-induced osteoclast differentiation in RAW264.7 cells.
Title: Ctdnep1 phosphatase is required for negative regulation of RANKL-induced osteoclast differentiation in RAW264.7 cells.
Accumulation of gammadeltaT cells in the decidua is promoted by RANKL which upregulates ICAM-1 via NF-kappaB.
Title: Accumulation of γδT cells in the decidua is promoted by RANKL which upregulates ICAM-1 via NF-κB.
Osteocyte RANKL Drives Bone Resorption in Mouse Ligature-Induced Periodontitis.
Title: Osteocyte RANKL Drives Bone Resorption in Mouse Ligature-Induced Periodontitis.
Dysfunction of poly (ADP-ribose) glycohydrolase suppresses osteoclast differentiation in RANKL-stimulated RAW264 cells.
Title: Dysfunction of poly (ADP-ribose) glycohydrolase suppresses osteoclast differentiation in RANKL-stimulated RAW264 cells.
The effect of osteocyte-derived RANKL on bone graft remodeling: An in vivo experimental study.
Title: The effect of osteocyte-derived RANKL on bone graft remodeling: An in vivo experimental study.
RANKL/RANK is required for cytokine-induced beta cell death; osteoprotegerin, a RANKL inhibitor, reverses rodent type 1 diabetes.
Title: RANKL/RANK is required for cytokine-induced beta cell death; osteoprotegerin, a RANKL inhibitor, reverses rodent type 1 diabetes.

Submit: New GeneRIF Correction See all GeneRIFs (551)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (11) 1 citation
Spontaneous (1) 1 citation
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:495499

NoName (e-PCR)
- UniSTS:485010

AF053713 (e-PCR)
- UniSTS:160413

PMC27122P1 (e-PCR)
- UniSTS:272374

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor superfamily binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone resorption	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lymph node development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within mammary gland alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocyte chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoclast development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of osteoclast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within osteoclast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within paracrine signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone resorption	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of corticotropin-releasing hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fever generation by positive regulation of prostaglandin secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of homotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of osteoclast development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoclast differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of osteoclast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of actin binding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within tooth eruption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor ligand superfamily member 11

Names: OPG ligand; TNF-related activation-induced cytokine; osteoclast differentiation factor; osteoprotegerin ligand; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa-B ligand; tumor necrosis factor-related activation-induced cytokine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.