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    Mbip MAP3K12 binding inhibitory protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 217588, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Mbipprovided by MGI
    Official Full Name
    MAP3K12 binding inhibitory protein 1provided by MGI
    Primary source
    MGI:MGI:1918320
    See related
    Ensembl:ENSMUSG00000021028 AllianceGenome:MGI:1918320
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933408E06Rik
    Summary
    Predicted to enable identical protein binding activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Located in nucleus. Part of ATAC complex. Is expressed in lung and telencephalon. Orthologous to human MBIP (MAP3K12 binding inhibitory protein 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 9.9), CNS E11.5 (RPKM 9.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mbip in Genome Data Viewer
    Location:
    12 C1; 12 24.3 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (56375091..56392681, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (56328306..56345933, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19990 Neighboring gene predicted gene, 46351 Neighboring gene STARR-seq mESC enhancer starr_32208 Neighboring gene predicted gene, 53723 Neighboring gene STARR-positive B cell enhancer ABC_E2385 Neighboring gene cytochrome c oxidase subunit 6C2 Neighboring gene STARR-positive B cell enhancer ABC_E5330 Neighboring gene STARR-positive B cell enhancer ABC_E8887 Neighboring gene STARR-positive B cell enhancer ABC_E10750 Neighboring gene predicted gene, 18027

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs. Ochieng JK, et al. Oncogene, 2020 Oct. PMID 32963352, Free PMC Article
    2. The mouse FKBP23 binds to BiP in ER and the binding of C-terminal domain is interrelated with Ca2+ concentration. Zhang X, et al. FEBS Lett, 2004 Feb 13. PMID 14960307
    3. Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. Tucker ES, et al. J Neurosci, 2008 Sep 17. PMID 18799682, Free PMC Article
    4. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
    5. The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes. Nagy Z, et al. Cell Mol Life Sci, 2010 Feb. PMID 19936620, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs.
      Title: MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis by JNK-dependent activation of MMPs.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7681

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell division IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of embryonic development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tubulin deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAP3K12-binding inhibitory protein 1
    Names
    MAPK upstream kinase-binding inhibitory protein
    MUK-binding inhibitory protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145442.2 → NP_663417.1  MAP3K12-binding inhibitory protein 1

      See identical proteins and their annotated locations for NP_663417.1

      Status: VALIDATED

      Source sequence(s)
      AC154714, AK077125
      Consensus CDS
      CCDS25920.1
      UniProtKB/Swiss-Prot
      Q3TBM3, Q99LQ1
      Related
      ENSMUSP00000021416.8, ENSMUST00000021416.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      56375091..56392681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246648.2 → XP_030102508.1  MAP3K12-binding inhibitory protein 1 isoform X3

    2. XM_006515674.5 → XP_006515737.1  MAP3K12-binding inhibitory protein 1 isoform X2

    3. XM_006515673.5 → XP_006515736.1  MAP3K12-binding inhibitory protein 1 isoform X1

    4. XM_017315023.3 → XP_017170512.1  MAP3K12-binding inhibitory protein 1 isoform X5

    5. XM_017315021.3 → XP_017170510.1  MAP3K12-binding inhibitory protein 1 isoform X4

    RNA

    1. XR_004937488.1 RNA Sequence

    2. XR_004937487.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LQ1.1 GenPept UniProtKB/Swiss-Prot:Q99LQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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