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    Gpr142 G protein-coupled receptor 142 [ Mus musculus (house mouse) ]

    Gene ID: 217302, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gpr142provided by MGI
    Official Full Name
    G protein-coupled receptor 142provided by MGI
    Primary source
    MGI:MGI:2668437
    See related
    Ensembl:ENSMUSG00000034677 AllianceGenome:MGI:2668437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PGR2
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in cell junction and cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; gonad; hemolymphoid system; sensory organ; and trigeminal ganglion. Orthologous to human GPR142 (G protein-coupled receptor 142). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Gpr142 in Genome Data Viewer
    Location:
    11 E2; 11 80.54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (114689750..114697571)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (114798924..114806745)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dynein axonemal intermediate chain 2 Neighboring gene STARR-positive B cell enhancer mm9_chr11:114606533-114606834 Neighboring gene kinesin family member 19A Neighboring gene BTB domain containing 17 Neighboring gene G protein-coupled receptor, family C, group 5, member C Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:114734569-114734722 Neighboring gene STARR-seq mESC enhancer starr_31138 Neighboring gene CD300A molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent. Al-Amily IM, et al. Pflugers Arch, 2019 Apr. PMID 30767071, Free PMC Article
    2. GPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose Metabolism. Lin HV, et al. PLoS One, 2016. PMID 27322810, Free PMC Article
    3. The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones. Rudenko O, et al. Mol Metab, 2019 Jan. PMID 30472415, Free PMC Article
    4. Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development. Süsens U, et al. Neuropharmacology, 2006 Mar. PMID 16378626
    5. Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice. Takeshita S, et al. Mamm Genome, 2006 Sep. PMID 16964447

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The importance of Gpr142 in the maintenance of pancreatic beta-cell function.
      Title: The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent.
    2. GPR142 functions as a sensor of aromatic amino acids, controlling GIP but also CCK and GLP-1 as well as insulin and glucagon in the pancreas.
      Title: The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.
    3. these findings demonstrate GPR142 is a Tryptophan receptor critically required for insulin and incretin hormone regulation and suggest GPR142 agonists may be effective therapies that leverage amino acid sensing pathways for the treatment of type 2 diabetes.
      Title: GPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose Metabolism.
    4. GPR142 mRNA showed a ubiquitous expression both in the brain and in various peripheral glands and organs in pre- and postnatal development.
      Title: Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 142
    Names
    G protein-coupled receptor PGR2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346772.1 → NP_001333701.1  probable G-protein coupled receptor 142 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL663079, AL669969
      Consensus CDS
      CCDS83922.1
      UniProtKB/TrEMBL
      Q1XA02
      Related
      ENSMUSP00000102194.2, ENSMUST00000106584.2

    2. NM_001379097.1 → NP_001366026.1  probable G-protein coupled receptor 142 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL669969
      UniProtKB/TrEMBL
      A0A1C9J7L2
      Conserved Domains (2) summary
      cd14964
      Location:48 → 74
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:47 → 315
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. NM_181749.1 → NP_861414.1  probable G-protein coupled receptor 142 isoform 1

      See identical proteins and their annotated locations for NP_861414.1

      Status: VALIDATED

      Source sequence(s)
      AY288428
      Consensus CDS
      CCDS25611.1
      UniProtKB/Swiss-Prot
      Q7TQN9
      UniProtKB/TrEMBL
      A2AD24
      Related
      ENSMUSP00000045029.3, ENSMUST00000045319.9
      Conserved Domains (1) summary
      pfam00001
      Location:94 → 321
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      114689750..114697571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQN9.1 GenPept UniProtKB/Swiss-Prot:Q7TQN9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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