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    Phlda1 pleckstrin homology like domain, family A, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 21664, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Phlda1provided by MGI
    Official Full Name
    pleckstrin homology like domain, family A, member 1provided by MGI
    Primary source
    MGI:MGI:1096880
    See related
    Ensembl:ENSMUSG00000020205 AllianceGenome:MGI:1096880
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tdag; TDAG51; DT1P1B11
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity. Acts upstream of or within FasL biosynthetic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; limb segment; respiratory system; and sensory organ. Orthologous to human PHLDA1 (pleckstrin homology like domain family A member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 67.6), stomach adult (RPKM 50.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Phlda1 in Genome Data Viewer
    Location:
    10 D1; 10 58.7 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (111342147..111344510)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (111506286..111508649)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene nucleosome assembly protein 1-like 1 Neighboring gene predicted gene, 25117 Neighboring gene STARR-positive B cell enhancer ABC_E6922 Neighboring gene high mobility group box 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:110947179-110947288 Neighboring gene predicted gene, 53630 Neighboring gene predicted gene, 30193

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TDAG51 deficiency attenuates dextran sulfate sodium-induced colitis in mice. Jeon H, et al. Sci Rep, 2022 Nov 30. PMID 36450854, Free PMC Article
    2. The Pleckstrin homology like domain family member, TDAG51, is temporally regulated during skeletal muscle regeneration. Coleman SK, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29127005
    3. TDAG51 is a crucial regulator of maternal care and depressive-like behavior after parturition. Yun H, et al. PLoS Genet, 2019 Jun. PMID 31251738, Free PMC Article
    4. Up-regulation of TDAG51 is a dependent factor of LPS-induced RAW264.7 macrophages proliferation and cell cycle progression. Jiao HW, et al. Immunopharmacol Immunotoxicol, 2016. PMID 26873343
    5. Regulation of PHLDA1 Expression by JAK2-ERK1/2-STAT3 Signaling Pathway. Lyu JH, et al. J Cell Biochem, 2016 Feb. PMID 26239656

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Egr1 promotes Nlrc4-dependent neuronal pyroptosis through phlda1 in an in-vitro model of intracerebral hemorrhage.
      Title: Egr1 promotes Nlrc4-dependent neuronal pyroptosis through phlda1 in an in-vitro model of intracerebral hemorrhage.
    2. Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice.
      Title: Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice.
    3. FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis.
      Title: FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis.
    4. Knockdown of PHLDA1 alleviates sepsis-induced acute lung injury by downregulating NLRP3 inflammasome activation.
      Title: Knockdown of PHLDA1 alleviates sepsis-induced acute lung injury by downregulating NLRP3 inflammasome activation.
    5. TDAG51 promotes transcription factor FoxO1 activity during LPS-induced inflammatory responses.
      Title: TDAG51 promotes transcription factor FoxO1 activity during LPS-induced inflammatory responses.
    6. TDAG51 Attenuates Impaired Lipid Metabolism and Insulin Resistance in Gestational Diabetes Mellitus Through SREBP-1/ANGPTL8 Pathway.
      Title: TDAG51 Attenuates Impaired Lipid Metabolism and Insulin Resistance in Gestational Diabetes Mellitus Through SREBP-1/ANGPTL8 Pathway.
    7. Knockdown of PHLDA1 Alleviates Necrotizing Enterocolitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling.
      Title: Knockdown of PHLDA1 Alleviates Necrotizing Enterocolitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling.
    8. PHLDA1 knockdown alleviates mitochondrial dysfunction and endoplasmic reticulum stress-induced neuronal apoptosis via activating PPARgamma in cerebral ischemia-reperfusion injury.
      Title: PHLDA1 knockdown alleviates mitochondrial dysfunction and endoplasmic reticulum stress-induced neuronal apoptosis via activating PPARγ in cerebral ischemia-reperfusion injury.
    9. TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3beta Pathway.
      Title: TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT-GSK-3β Pathway.
    10. PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip.
      Title: PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within FasL biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology-like domain family A member 1
    Names
    PQ-rich protein
    PQR protein
    T-cell death associated
    T-cell death-associated gene 51 protein
    proline- and glutamine-rich protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009344.3 → NP_033370.2  pleckstrin homology-like domain family A member 1

      See identical proteins and their annotated locations for NP_033370.2

      Status: VALIDATED

      Source sequence(s)
      BY378082, U44088
      Consensus CDS
      CCDS24167.2
      UniProtKB/Swiss-Prot
      Q3TY48, Q3UG87, Q62392
      Related
      ENSMUSP00000132815.2, ENSMUST00000164773.2
      Conserved Domains (2) summary
      smart00233
      Location:154 → 261
      PH; Pleckstrin homology domain
      pfam12286
      Location:250 → 274
      DUF3622; Protein of unknown function (DUF3622)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      111342147..111344510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62392.2 GenPept UniProtKB/Swiss-Prot:Q62392

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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