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    Rassf4 Ras association (RalGDS/AF-6) domain family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 213391, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rassf4provided by MGI
    Official Full Name
    Ras association (RalGDS/AF-6) domain family member 4provided by MGI
    Primary source
    MGI:MGI:2386853
    See related
    Ensembl:ENSMUSG00000042129 AllianceGenome:MGI:2386853
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AD037; 3830411C14Rik
    Summary
    Predicted to be involved in signal transduction. Is expressed in nasal cavity epithelium; nervous system; and neural retina. Orthologous to human RASSF4 (Ras association domain family member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 9.8), spleen adult (RPKM 8.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rassf4 in Genome Data Viewer
    Location:
    6 E3; 6 53.83 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (116609969..116650797, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (116633008..116673836, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene crumbs homolog 1 pseudogene Neighboring gene zinc finger protein 422 Neighboring gene STARR-seq mESC enhancer starr_17106 Neighboring gene STARR-positive B cell enhancer ABC_E6474 Neighboring gene microRNA 7043 Neighboring gene DEPP1 autophagy regulator Neighboring gene STARR-positive B cell enhancer ABC_E2202 Neighboring gene STARR-positive B cell enhancer mm9_chr6:116632394-116632695 Neighboring gene transmembrane protein 72 Neighboring gene predicted gene, 22882

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord. Lai HC, et al. J Neurosci, 2011 Jul 27. PMID 21795538, Free PMC Article
    2. Applying gene expression, proteomics and single-nucleotide polymorphism analysis for complex trait gene identification. Stylianou IM, et al. Genetics, 2008 Mar. PMID 18245842, Free PMC Article
    3. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ras association domain-containing protein 4
    Names
    Ras association (RalGDS/AF-6) domain family 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178045.4 → NP_835146.3  ras association domain-containing protein 4

      See identical proteins and their annotated locations for NP_835146.3

      Status: VALIDATED

      Source sequence(s)
      AC160973, AK036528, BC060709, BY170346
      Consensus CDS
      CCDS20460.1
      UniProtKB/Swiss-Prot
      Q3TBK1, Q3TPH9, Q3TUT0, Q6P9L7, Q8CB96, Q8CIM6
      Related
      ENSMUSP00000048267.5, ENSMUST00000035842.7
      Conserved Domains (1) summary
      cl00155
      Location:176 → 262
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      116609969..116650797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505866.5 → XP_006505929.1  ras association domain-containing protein 4 isoform X1

      Conserved Domains (2) summary
      PHA03309
      Location:60 → 163
      PHA03309; transcriptional regulator ICP4; Provisional
      cd17222
      Location:151 → 237
      RA_RASSF4; Ras-associating (RA) domain found in Ras-association domain-containing protein 4 (RASSF4)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CB96.1 GenPept UniProtKB/Swiss-Prot:Q8CB96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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