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    Prss27 serine protease 27 [ Mus musculus (house mouse) ]

    Gene ID: 213171, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Prss27provided by MGI
    Official Full Name
    serine protease 27provided by MGI
    Primary source
    MGI:MGI:2450123
    See related
    Ensembl:ENSMUSG00000050762 AllianceGenome:MGI:2450123
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mpn; CAPH2; marapsin
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in plasma membrane. Is expressed in eye; stomach; and uterus. Orthologous to human PRSS27 (serine protease 27). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 8.9), stomach adult (RPKM 8.5) and 10 other tissues See more
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    Genomic context

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    See Prss27 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.21 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24257217..24264923)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24038243..24045949)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42070 Neighboring gene predicted gene, 25092 Neighboring gene peroxiredoxin 2 pseudogene Neighboring gene potassium channel tetramerisation domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E8657 Neighboring gene 3-phosphoinositide dependent protein kinase 1 Neighboring gene STARR-seq mESC enhancer starr_42072 Neighboring gene STARR-seq mESC enhancer starr_42074 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:24274163-24274452 Neighboring gene STARR-positive B cell enhancer ABC_E1935 Neighboring gene predicted gene, 33409

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. Raman K, et al. J Biol Chem, 2013 Apr 12. PMID 23447538, Free PMC Article
    2. The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. Li W, et al. J Biol Chem, 2009 Jan 2. PMID 18948266
    3. Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. Bhagwandin VJ, et al. J Biol Chem, 2003 Jan 31. PMID 12441343
    4. Identification of a subgroup of glycosylphosphatidylinositol-anchored tryptases. Wong GW, et al. Biochem Biophys Res Commun, 2005 Oct 21. PMID 16143303
    5. Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns. Wong GW, et al. J Biol Chem, 2004 Jan 23. PMID 14583634

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors.
      Title: Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors.
    2. Marapsin's restricted expression, localization, and cytokine-inducible expression suggest a role in the terminal differentiation of keratinocytes in hyperproliferating squamous epithelia.
      Title: The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine protease 27
    Names
    channel-activating protease 2-like protein
    pancreasin
    protease, serine 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175440.4 → NP_780649.1  serine protease 27 precursor

      See identical proteins and their annotated locations for NP_780649.1

      Status: PROVISIONAL

      Source sequence(s)
      CT010502
      Consensus CDS
      CCDS28472.1
      UniProtKB/Swiss-Prot
      Q14A25, Q8BJR6
      Related
      ENSMUSP00000056483.6, ENSMUST00000059482.6
      Conserved Domains (2) summary
      smart00020
      Location:37 → 275
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:39 → 278
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24257217..24264923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJR6.1 GenPept UniProtKB/Swiss-Prot:Q8BJR6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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