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    Swap70 SWA-70 protein [ Mus musculus (house mouse) ]

    Gene ID: 20947, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Swap70provided by MGI
    Official Full Name
    SWA-70 proteinprovided by MGI
    Primary source
    MGI:MGI:1298390
    See related
    Ensembl:ENSMUSG00000031015 AllianceGenome:MGI:1298390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    70kDa
    Summary
    Enables ATP binding activity and DNA binding activity. Involved in several processes, including negative regulation of cell-cell adhesion mediated by integrin; positive regulation of mast cell chemotaxis; and regulation of actin filament organization. Acts upstream of or within isotype switching. Located in nucleus. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SWAP70 (switching B cell complex subunit SWAP70). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 24.4), lung adult (RPKM 11.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Swap70 in Genome Data Viewer
    Location:
    7 E3; 7 57.7 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109820890..109882720)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110221703..110283506)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E293 Neighboring gene STARR-positive B cell enhancer ABC_E6584 Neighboring gene WEE 1 homolog 1 (S. pombe) Neighboring gene VISTA enhancer mm725 Neighboring gene STARR-seq mESC enhancer starr_19821 Neighboring gene predicted gene, 51505 Neighboring gene STARR-positive B cell enhancer ABC_E8201 Neighboring gene STARR-positive B cell enhancer ABC_E704 Neighboring gene STARR-positive B cell enhancer ABC_E9296 Neighboring gene predicted gene, 32861 Neighboring gene 40S ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs. Pearce G, et al. Nat Immunol, 2006 Aug. PMID 16845395
    2. SWAP-70 contributes to spontaneous transformation of mouse embryo fibroblasts. Chang YT, et al. Exp Cell Res, 2016 Jul 15. PMID 26103139
    3. SWAP-70 regulates mast cell FcepsilonRI-mediated signaling and anaphylaxis. Sivalenka RR, et al. Eur J Immunol, 2008 Mar. PMID 18236401, Free PMC Article
    4. Tolerogenic versus Immunogenic Lipidomic Profiles of CD11c(+) Immune Cells and Control of Immunogenic Dendritic Cell Ceramide Dynamics. Ocaña-Morgner C, et al. J Immunol, 2017 Jun 1. PMID 28468968
    5. SWAP-70: a new type of oncogene. Shu CL, et al. PLoS One, 2013. PMID 23555004, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The F-actin bundler SWAP-70 promotes tumor metastasis.
      Title: The F-actin bundler SWAP-70 promotes tumor metastasis.
    2. SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1-Dependent Manner.
      Title: SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1-Dependent Manner.
    3. Mechanism of control of F-actin cortex architecture by SWAP-70.
      Title: Mechanism of control of F-actin cortex architecture by SWAP-70.
    4. Control of GM-CSF-Dependent Dendritic Cell Differentiation and Maturation by DEF6 and SWAP-70.
      Title: Control of GM-CSF-Dependent Dendritic Cell Differentiation and Maturation by DEF6 and SWAP-70.
    5. Data support an essential and specific role for SWAP70 in tethering and stabilizing F-actin to the phagosomal surface in a wide range of phagocytes.
      Title: SWAP70 is a universal GEF-like adaptor for tethering actin to phagosomes.
    6. Studies indicate that the autoimmune phenotype in DEF6 and SWAP-70 knock-out (DKO) mice is characterized by the accumulation of B cell subset that expresses high levels of CD11c and T-bet (ABCs).
      Title: Regulation of systemic autoimmunity and CD11c(+) Tbet(+) B cells by SWEF proteins.
    7. findings show characteristic changes in the lipidome of CD11c+ immune cells upon their activation, and reveal an important role of SWAP-70 in the selective generation and localization of ceramides
      Title: Tolerogenic versus Immunogenic Lipidomic Profiles of CD11c(+) Immune Cells and Control of Immunogenic Dendritic Cell Ceramide Dynamics.
    8. DEF6 and SWAP70 are SWEF proteins with important contributors to hematopoietic stem and precursor cells biology
      Title: SWEF Proteins Distinctly Control Maintenance and Differentiation of Hematopoietic Stem Cells.
    9. SWAP-70 is not a typical oncogene, but is required for spontaneous transformation of mouse embryo fibroblasts.
      Title: SWAP-70 contributes to spontaneous transformation of mouse embryo fibroblasts.
    10. These findings reveal an important role of SWAP-70 in the dynamic spatiotemporal regulation of F-actin networks.
      Title: The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within isotype switching IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell-cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mast cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin polymerization or depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic cell DNA recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    switch-associated protein 70
    Names
    SWAP complex protein, 70 kDa
    SWAP-70

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417315.1 → NP_001404244.1  switch-associated protein 70 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124472, AC147244

    2. NM_009302.4 → NP_033328.3  switch-associated protein 70 isoform 1

      See identical proteins and their annotated locations for NP_033328.3

      Status: VALIDATED

      Source sequence(s)
      AC124472, AC147244
      Consensus CDS
      CCDS21744.1
      UniProtKB/Swiss-Prot
      O88443, Q3TQR6, Q3UCA3, Q6A028, Q6P1D0
      Related
      ENSMUSP00000033325.8, ENSMUST00000033325.9
      Conserved Domains (4) summary
      cd13273
      Location:204 → 313
      PH_SWAP-70; Switch-associated protein-70 Pleckstrin homology (PH) domain
      pfam00169
      Location:211 → 306
      PH; PH domain
      pfam15665
      Location:316 → 527
      FAM184; Family with sequence similarity 184, A and B
      cl23849
      Location:321 → 455
      TrbI; Bacterial conjugation TrbI-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      109820890..109882720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152861.1 → XP_036008754.1  switch-associated protein 70 isoform X1

      Conserved Domains (2) summary
      TIGR02168
      Location:74 → 291
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:5 → 55
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6A028.2 GenPept UniProtKB/Swiss-Prot:Q6A028

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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