Eif5a2 eukaryotic translation initiation factor 5A2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif5a2provided by MGI
Official Full Name: eukaryotic translation initiation factor 5A2provided by MGI
Primary source: MGI:MGI:1933735
See related: Ensembl:ENSMUSG00000050192 AllianceGenome:MGI:1933735
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: eIF5AII; 9630038B20
Summary: Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be located in intracellular membrane-bounded organelle. Orthologous to human EIF5A2 (eukaryotic translation initiation factor 5A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 10.7), cortex adult (RPKM 6.2) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A3; 3 12.25 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (28835426..28852995)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (28781032..28798846)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

microRNA-15a-5p suppresses hypoxia-induced tumor growth and chemoresistance in bladder cancer by binding to eIF5A2.
Title: microRNA-15a-5p suppresses hypoxia-induced tumor growth and chemoresistance in bladder cancer by binding to eIF5A2.
A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates beta-Cell Identity and Function.
Title: A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates β-Cell Identity and Function.
New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape.
Title: New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape.
Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy and cisplatin resistance.
Title: Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy and cisplatin resistance.
activation of eIF-5A2 repressed p19 level and therefore destabilized p53 in transgenic mouse embryo fibroblast (MEF) cells. This subsequently allowed for the accumulation of chromosomal instability.
Title: Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability.
Eukaryotic initiation factor 5A (eIF5A) (eIF-4D, eIF-5A) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys 50. Mouse EIF5A1 and EIF5A2 encode two isoforms: eIF5AI and eIF5AII.
Title: Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489553

BB447685 (e-PCR)
- UniSTS:207472

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of translational elongation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational termination	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 5A-2

Names: eukaryotic initiation factor 5A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177586.6 → NP_808254.1 eukaryotic translation initiation factor 5A-2

See identical proteins and their annotated locations for NP_808254.1

Status: VALIDATED

Source sequence(s)

AC122490

Consensus CDS

CCDS17277.1

UniProtKB/Swiss-Prot

Q8BGY2

Related

ENSMUSP00000050289.8, ENSMUST00000060500.9

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional