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    Stau1 staufen double-stranded RNA binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 20853, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Stau1provided by MGI
    Official Full Name
    staufen double-stranded RNA binding protein 1provided by MGI
    Primary source
    MGI:MGI:1338864
    See related
    Ensembl:ENSMUSG00000039536 AllianceGenome:MGI:1338864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Stau; 5830401L18Rik
    Summary
    Enables RNA binding activity. Involved in dendritic transport of messenger ribonucleoprotein complex. Acts upstream of or within intracellular mRNA localization. Located in cytoplasmic stress granule and neuron projection. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; gonad; and sensory organ. Orthologous to human STAU1 (staufen double-stranded RNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 16.8), adrenal adult (RPKM 16.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stau1 in Genome Data Viewer
    Location:
    2 H3; 2 87.22 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (166789469..166838253, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (166947549..166996315, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6021 Neighboring gene ADP ribosylation factor guanine nucleotide exchange factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E10161 Neighboring gene STARR-positive B cell enhancer ABC_E2654 Neighboring gene STARR-seq mESC enhancer starr_06416 Neighboring gene STARR-positive B cell enhancer ABC_E2655 Neighboring gene predicted gene, 31204 Neighboring gene chromosome segregation 1 like Neighboring gene STARR-positive B cell enhancer ABC_E9541 Neighboring gene STARR-positive B cell enhancer ABC_E2656 Neighboring gene GLE1 RNA export mediator pseudogene Neighboring gene DEAD box helicase 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. STAU1 exhibits a dual function by promoting amyloidogenesis and tau phosphorylation in cultured cells. Li CL, et al. Exp Neurol, 2024 Jul. PMID 38729552
    2. A loss of function allele for murine Staufen1 leads to impairment of dendritic Staufen1-RNP delivery and dendritic spine morphogenesis. Vessey JP, et al. Proc Natl Acad Sci U S A, 2008 Oct 21. PMID 18922781, Free PMC Article
    3. STAU1 promotes adipogenesis by regulating the alternative splicing of Pparγ2 mRNA. Jiang S, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2023 May. PMID 36871938
    4. Stau1 negatively regulates myogenic differentiation in C2C12 cells. Yamaguchi Y, et al. Genes Cells, 2008 Jun. PMID 18422603
    5. Genomic organization of the human and mouse stau genes. Brizard F, et al. DNA Cell Biol, 2000 Jun. PMID 10882232

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration.
      Title: Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration.
    2. STAU1 exhibits a dual function by promoting amyloidogenesis and tau phosphorylation in cultured cells.
      Title: STAU1 exhibits a dual function by promoting amyloidogenesis and tau phosphorylation in cultured cells.
    3. STAU1 promotes adipogenesis by regulating the alternative splicing of Ppargamma2 mRNA.
      Title: STAU1 promotes adipogenesis by regulating the alternative splicing of Pparγ2 mRNA.
    4. Staufen 1 is expressed by neural precursor cells in the developing murine cortex but is dispensable for NPC self-renewal and neuronal differentiation in vitro.
      Title: Staufen 1 is expressed by neural precursor cells in the developing murine cortex but is dispensable for NPC self-renewal and neuronal differentiation in vitro.
    5. Staufen1 unwinds the secondary structure and facilitates the translation of fatty acid binding protein 4 mRNA during adipogenesis.
      Title: Staufen1 unwinds the secondary structure and facilitates the translation of fatty acid binding protein 4 mRNA during adipogenesis.
    6. Staufen 1 amplifies proapoptotic activation of the unfolded protein response.
      Title: Staufen 1 amplifies proapoptotic activation of the unfolded protein response.
    7. Overexpression of Staufen1 in DM1 mouse skeletal muscle exacerbates dystrophic and atrophic features.
      Title: Overexpression of Staufen1 in DM1 mouse skeletal muscle exacerbates dystrophic and atrophic features.
    8. Staufen1 in Human Neurodegeneration.
      Title: Staufen1 in Human Neurodegeneration.
    9. haploinsufficiency partially restored behavioral, proteomic, and morphological characteristics of spinocerebellar ataxia type 2 pathology in vivo
      Title: Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration.
    10. The results highlight a novel molecular mechanism underlying stability of neurogenesis-associated mRNAs controlled by the Klf4/Ddx5/Stau1 axis during mammalian corticogenesis.
      Title: Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 1 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde dendritic transport of messenger ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendritic transport of messenger ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dendritic transport of messenger ribonucleoprotein complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular mRNA localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular mRNA localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modification of postsynaptic structure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation by virus of viral protein levels in host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    double-stranded RNA-binding protein Staufen homolog 1
    Names
    staufen (RNA binding protein) homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109905.2 → NP_001103375.1  double-stranded RNA-binding protein Staufen homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_001103375.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK005002, AK139532, AL591711, BQ032760, BU757992
      Consensus CDS
      CCDS50800.1
      UniProtKB/TrEMBL
      Q3U8D3, Q9DBE7
      Related
      ENSMUSP00000104858.2, ENSMUST00000109235.8
      Conserved Domains (3) summary
      smart00358
      Location:98 → 161
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:198 → 264
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:360 → 469
      Staufen_C; Staufen C-terminal domain

    2. NM_001109906.2 → NP_001103376.1  double-stranded RNA-binding protein Staufen homolog 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK139532, AK160979, AL591711, BQ032760, BU757992
      Consensus CDS
      CCDS50801.1
      UniProtKB/TrEMBL
      A2A5S3, Q3U8D3
      Related
      ENSMUSP00000104861.3, ENSMUST00000109238.9
      Conserved Domains (3) summary
      smart00358
      Location:98 → 167
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:204 → 270
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:366 → 475
      Staufen_C; Staufen C-terminal domain

    3. NM_001291160.1 → NP_001278089.1  double-stranded RNA-binding protein Staufen homolog 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, and contains an alternate exon that results in a shorter 3' coding region and an additional segment in the 3' UTR, compared to variant 1. The encoded isoform (4) is shorter at the C-terminus, compared to isoform 1.
      Source sequence(s)
      AK139532, AK151835, AL591711, BQ032760, BU757992
      Consensus CDS
      CCDS71197.1
      UniProtKB/TrEMBL
      A2A5R8, Q3U7A6
      Related
      ENSMUSP00000042626.6, ENSMUST00000049412.12
      Conserved Domains (3) summary
      pfam16482
      Location:360 → 469
      Staufen_C; Staufen C-terminal domain
      cd19885
      Location:188 → 273
      DSRM_STAU1_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins
      cl00054
      Location:95 → 161
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

    4. NM_011490.4 → NP_035620.1  double-stranded RNA-binding protein Staufen homolog 1 isoform 3

      See identical proteins and their annotated locations for NP_035620.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AK139532, AK145826, AK159781, AL591711, BQ032760, BU757992
      Consensus CDS
      CCDS17093.1
      UniProtKB/Swiss-Prot
      Q9Z108
      UniProtKB/TrEMBL
      Q3U8D3
      Related
      ENSMUSP00000104859.3, ENSMUST00000109236.9
      Conserved Domains (3) summary
      smart00358
      Location:98 → 161
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:196 → 262
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam16482
      Location:358 → 467
      Staufen_C; Staufen C-terminal domain

    RNA

    1. NR_111895.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) is shorter in the 5' region and lacks an internal segment in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK139532, AK160979, AL591711, AY391773, BQ032760, BU757992

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      166789469..166838253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160105.1 → XP_036015998.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X2

      UniProtKB/TrEMBL
      A2A5R8, Q3U7A6
      Conserved Domains (3) summary
      pfam16482
      Location:360 → 469
      Staufen_C; Staufen C-terminal domain
      cd19885
      Location:188 → 273
      DSRM_STAU1_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins
      cl00054
      Location:95 → 161
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

    2. XM_006499071.3 → XP_006499134.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006499134.1

      UniProtKB/TrEMBL
      Q3U7A6
      Related
      ENSMUSP00000139039.2, ENSMUST00000184390.2
      Conserved Domains (3) summary
      pfam16482
      Location:366 → 475
      Staufen_C; Staufen C-terminal domain
      cd19885
      Location:194 → 279
      DSRM_STAU1_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins
      cl00054
      Location:95 → 167
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

    3. XM_006499072.3 → XP_006499135.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006499135.1

      UniProtKB/TrEMBL
      Q3U7A6
      Conserved Domains (3) summary
      pfam16482
      Location:366 → 475
      Staufen_C; Staufen C-terminal domain
      cd19885
      Location:194 → 279
      DSRM_STAU1_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins
      cl00054
      Location:95 → 167
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

    4. XM_030249042.1 → XP_030104902.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X4

      UniProtKB/TrEMBL
      Q3U8D3
      Conserved Domains (3) summary
      pfam16482
      Location:311 → 420
      Staufen_C; Staufen C-terminal domain
      cd19883
      Location:95 → 161
      DSRM_STAU1_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 1 (Staufen 1) and similar proteins
      cl00054
      Location:1 → 70
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

    5. XM_011239406.1 → XP_011237708.1  double-stranded RNA-binding protein Staufen homolog 1 isoform X3

      UniProtKB/TrEMBL
      Q3U8D3
      Conserved Domains (2) summary
      pfam16482
      Location:317 → 426
      Staufen_C; Staufen C-terminal domain
      cl00054
      Location:95 → 167
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

    RNA

    1. XR_004939216.1 RNA Sequence

    2. XR_004939214.1 RNA Sequence

    3. XR_004939215.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z108.1 GenPept UniProtKB/Swiss-Prot:Q9Z108

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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