Rps6ka1 ribosomal protein S6 kinase polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps6ka1provided by MGI
Official Full Name: ribosomal protein S6 kinase polypeptide 1provided by MGI
Primary source: MGI:MGI:104558
See related: Ensembl:ENSMUSG00000003644 AllianceGenome:MGI:104558
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rsk; Rsk1; Rsk-1; p90S6K; p90rsk; p90Rsk1; p90-Rsk1; Mapkapk-1a; S6K-alpha-1
Summary: Enables DNA-binding transcription factor binding activity and kinase activity. Involved in hepatocyte proliferation. Located in spindle. Is active in synapse. Is expressed in central nervous system; early conceptus; lumbar dorsal root ganglion; oocyte; and retina. Orthologous to human RPS6KA1 (ribosomal protein S6 kinase A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in duodenum adult (RPKM 79.7), colon adult (RPKM 69.8) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.37 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (133574601..133615466, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (133847290..133887797, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division.
Title: mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division.
combination antiretroviral therapy increased monocyte/macrophage sensitivity to reactive oxygen species- in HIV(+) individuals by suppressing NRF2-ARE activity via p90RSK-mediated ERK5 S496 phosphorylation, which coordinately elicited senescent phenotypes and proinflammatory responses
Title: Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals.
Data show that osteopontin (OPN) mediates Na(+)/H(+) exchanger isoform 1 (NHE1)-induced cardiac hypertrophy through p90 ribosomal S6 kinase (p90 RSK).
Title: Na(+)/H(+) exchanger isoform 1-induced osteopontin expression facilitates cardiac hypertrophy through p90 ribosomal S6 kinase.
Rsk1 and Rsk2 protein levels are specifically reduced in the striatum of Huntington's disease mouse models at symptomatic stage.
Title: Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease.
In hippocampal neurons of wild-type mice, pP90RSK translocates into the nucleus upon stimulation with forskolin (left), whereas in Period1-knockout (Per1(-/-) ) mice (right) the kinase is trapped at the nuclear periphery
Title: Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK.
Data show that the phosphoinositide-dependent kinase 1 (PDK1)-p90 kDa ribosomal S6 kinases (Rsks) Rsk1/2 pathway is critical for establishment and maintenance of a normal Langerhans cells (LC) network.
Title: The PDK1-Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning.
IL-6 induces the activation of the Stat3 signaling and promotes the downmodulation of the p90RSK/eEF2 and mTOR/p70S6K axes, while it does not affect the activation of AKT.
Title: IL-6 impairs myogenic differentiation by downmodulation of p90RSK/eEF2 and mTOR/p70S6K axes, without affecting AKT activity.
analysis of p38-MK2-activated Rsk signaling in toll-like receptor-stimulated dendritic cells
Title: Structural and functional basis for p38-MK2-activated Rsk signaling in toll-like receptor-stimulated dendritic cells.
These data indicate that aripiprazole and quetiapine signal to specific nuclear targets of ERK, which for quetiapine occurs via an EGFR-linked mechanism, possibly indicating involvement of this system in its action.
Title: Quetiapine and aripiprazole signal differently to ERK, p90RSK and c-Fos in mouse frontal cortex and striatum: role of the EGF receptor.
hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1, which via phosphorylation of NHE1 induces cardiomyocyte apoptosis.
Title: Interactions between the regulatory subunit of type I protein kinase A and p90 ribosomal S6 kinase1 regulate cardiomyocyte apoptosis.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rps6ka1 (e-PCR), detects polymorphism
- UniSTS:469820

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine/tyrosine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables ribosomal protein S6 kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatic stellate cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatic stellate cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ribosomal protein S6 kinase alpha-1

Names: 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1

NP_001272434.1

EC 2.7.11.1

NP_001272435.1

EC 2.7.11.1

NP_001365809.1

EC 2.7.11.1

NP_033123.2

EC 2.7.11.1

XP_036019817.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285505.1 → NP_001272434.1 ribosomal protein S6 kinase alpha-1 isoform b

See identical proteins and their annotated locations for NP_001272434.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

AL837508, BC049076, BY737295

Consensus CDS

CCDS71488.1

UniProtKB/Swiss-Prot

P18653

UniProtKB/TrEMBL

Q3UFZ5

Related

ENSMUSP00000003741.10, ENSMUST00000003741.16

Conserved Domains (4) summary

smart00220
Location:62 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05582
Location:66 → 371

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14175
Location:405 → 695

STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

pfam00069
Location:407 → 664

Pkinase; Protein kinase domain
NM_001285506.1 → NP_001272435.1 ribosomal protein S6 kinase alpha-1 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, and it initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

BC049076, BY226173, CA547794

Consensus CDS

CCDS71487.1

UniProtKB/TrEMBL

E9PWV3, Q3TIM6

Related

ENSMUSP00000126774.3, ENSMUST00000168974.9

Conserved Domains (4) summary

smart00220
Location:46 → 304

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05582
Location:50 → 366

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14175
Location:400 → 690

STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

pfam00069
Location:402 → 659

Pkinase; Protein kinase domain
NM_001378880.1 → NP_001365809.1 ribosomal protein S6 kinase alpha-1 isoform d

Status: VALIDATED

Source sequence(s)

AL837508

UniProtKB/TrEMBL

F6Q8A4, Q3TIM6

Related

ENSMUSP00000119328.3, ENSMUST00000137486.3

Conserved Domains (2) summary

cd05582
Location:72 → 388

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14175
Location:422 → 712

STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
NM_009097.5 → NP_033123.2 ribosomal protein S6 kinase alpha-1 isoform a

See identical proteins and their annotated locations for NP_033123.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AL837508, BC049076, BY737295

Consensus CDS

CCDS18758.2

UniProtKB/TrEMBL

Q3UFZ5, Q505N6

Related

ENSMUSP00000101514.5, ENSMUST00000105894.11

Conserved Domains (2) summary

cd05582
Location:66 → 382

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14175
Location:416 → 706

STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

133574601..133615466 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163924.1 → XP_036019817.1 ribosomal protein S6 kinase alpha-1 isoform X1

UniProtKB/TrEMBL

Q3UFZ5, Q505N6

Conserved Domains (2) summary

cd05582
Location:66 → 382

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14175
Location:416 → 706

STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)