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    Ren1 renin 1 structural [ Mus musculus (house mouse) ]

    Gene ID: 19701, updated on 29-Oct-2024

    Summary

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    Official Symbol
    Ren1provided by MGI
    Official Full Name
    renin 1 structuralprovided by MGI
    Primary source
    MGI:MGI:97898
    See related
    Ensembl:ENSMUSG00000070645 AllianceGenome:MGI:97898
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ren; Rnr; Rn-1; Ren-1; Ren-A; Ren1c; Ren1d
    Summary
    Enables endopeptidase activity. Involved in male gonad development and mesonephros development. Acts upstream of or within with a positive effect on regulation of blood pressure. Acts upstream of or within several processes, including drinking behavior; hormone-mediated signaling pathway; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and trunk. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in kidney adult (RPKM 87.3) and ovary adult (RPKM 3.3) See more
    Orthologs
    human all
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    Genomic context

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    See Ren1 in Genome Data Viewer
    Location:
    1 E4; 1 57.91 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133278412..133288058)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133350674..133360320)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene golgi transport 1A Neighboring gene predicted gene, 53474 Neighboring gene KiSS-1 metastasis-suppressor Neighboring gene Ren1 promoter and enhancer region Neighboring gene STARR-positive B cell enhancer ABC_E11089 Neighboring gene ethanolamine kinase 2 Neighboring gene SRY (sex determining region Y)-box 13 Neighboring gene STARR-seq mESC enhancer starr_02283

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Contribution of circulating renin to local synthesis of angiotensin peptides in the heart. Prescott G, et al. Physiol Genomics, 2000 Nov 9. PMID 11074015
    2. Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Xu D, et al. Hypertension, 2009 Dec. PMID 19822797, Free PMC Article
    3. Opposite regulation of renin gene expression by cyclic AMP and calcium in isolated mouse juxtaglomerular cells. Della Bruna R, et al. Kidney Int, 1995 May. PMID 7637256
    4. Biosynthesis of renin in mouse kidney tumor As4.1 cells. Jones CA, et al. Eur J Biochem, 1997 Jan 15. PMID 9030738
    5. Renin-1 is essential for normal renal juxtaglomerular cell granulation and macula densa morphology. Clark AF, et al. J Biol Chem, 1997 Jul 18. PMID 9218454

    See all (244) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vitamin D/VDR regulates peripheral energy homeostasis via central renin-angiotensin system.
      Title: Vitamin D/VDR regulates peripheral energy homeostasis via central renin-angiotensin system.
    2. In Vivo Renin Activity Imaging in the Kidney of Progeroid Ercc1 Mutant Mice.
      Title: In Vivo Renin Activity Imaging in the Kidney of Progeroid Ercc1 Mutant Mice.
    3. Advances in use of mouse models to study the renin-angiotensin system.
      Title: Advances in use of mouse models to study the renin-angiotensin system.
    4. Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis.
      Title: Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis.
    5. Intermittent Hypoxia Upregulates the Renin and Cd38 mRNAs in Renin-Producing Cells via the Downregulation of miR-203.
      Title: Intermittent Hypoxia Upregulates the Renin and Cd38 mRNAs in Renin-Producing Cells via the Downregulation of miR-203.
    6. Alteration of Cx37, Cx40, Cx43, Cx45, Panx1, and Renin Expression Patterns in Postnatal Kidneys of Dab1-/- (yotari) Mice.
      Title: Alteration of Cx37, Cx40, Cx43, Cx45, Panx1, and Renin Expression Patterns in Postnatal Kidneys of Dab1-/- (yotari) Mice.
    7. Ctcf is required for renin expression and maintenance of the structural integrity of the kidney.
      Title: Ctcf is required for renin expression and maintenance of the structural integrity of the kidney.
    8. This study reveals that the human renin protein is able to complement the mouse Ren1d(-/-) non-granulated defect and suggests that granulopoiesis requires a structural motif that is conserved between the mouse Ren1d and human renin proteins.
      Title: Phenotypic dissection of the mouse Ren1d knockout by complementation with human renin.
    9. These observations demonstrate that activation of the renin-angiotensin system (RAS) promotes colitis in a blood pressure independent manner. Angiotensin II appears to drive colonic mucosal inflammation by promoting intestinal epithelial cell apoptosis and mucosal TH17 responses in colitis development.
      Title: Activation of the Renin-Angiotensin System Promotes Colitis Development.
    10. PGE2 serves as a central regulator of the Ren-1c gene in the principal cells of the kidney collecting ducts via the PKC/cAMP/CREB pathway.
      Title: PGE(2) upregulates renin through E-prostanoid receptor 1 via PKC/cAMP/CREB pathway in M-1 cells.
    Submit: New GeneRIF Correction See all GeneRIFs (68)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartic-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables insulin-like growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin-like growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in amyloid-beta metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in angiotensin maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within angiotensin maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in angiotensin maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within drinking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT acts_upstream_of_or_within establishment of blood-nerve barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hormone-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in juxtaglomerular apparatus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mesonephros development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within_positive_effect regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of blood volume by renin-angiotensin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within renin-angiotensin regulation of aldosterone production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to cAMP IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cAMP ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cGMP IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cGMP ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to immobilization stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    renin-1
    Names
    angiotensinogenase
    aspartyl-protease
    kidney renin
    renin b
    NP_112469.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031192.3 → NP_112469.1  renin-1 precursor

      See identical proteins and their annotated locations for NP_112469.1

      Status: VALIDATED

      Source sequence(s)
      AC068906, AK085309
      Consensus CDS
      CCDS15295.1
      UniProtKB/Swiss-Prot
      P00796, P06281, P70229, P97911, P97955, Q543E5, Q62153, Q62154, Q62155
      Related
      ENSMUSP00000092135.3, ENSMUST00000094556.3
      Conserved Domains (3) summary
      cd05487
      Location:76 → 401
      renin_like; Renin stimulates production of angiotensin and thus affects blood pressure
      pfam00026
      Location:83 → 401
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:29 → 54
      A1_Propeptide; A1 Propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      133278412..133288058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06281.1 GenPept UniProtKB/Swiss-Prot:P06281

    Gene LinkOut

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