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    Pxmp2 peroxisomal membrane protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 19301, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pxmp2provided by MGI
    Official Full Name
    peroxisomal membrane protein 2provided by MGI
    Primary source
    MGI:MGI:107487
    See related
    Ensembl:ENSMUSG00000029499 AllianceGenome:MGI:107487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PMP22
    Summary
    Located in mitochondrion. Orthologous to human PXMP2 (peroxisomal membrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 63.7), heart adult (RPKM 27.3) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pxmp2 in Genome Data Viewer
    Location:
    5 F; 5 53.44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110422152..110434036, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110274286..110286222, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and LEM domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_13949 Neighboring gene phosphoglycerate mutase family member 5 Neighboring gene STARR-positive B cell enhancer ABC_E6363 Neighboring gene polymerase (DNA directed), epsilon Neighboring gene predicted gene, 26277 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice. Vapola MH, et al. Dev Biol, 2014 Jul 1. PMID 24726525
    2. Pxmp2 is a channel-forming protein in Mammalian peroxisomal membrane. Rokka A, et al. PLoS One, 2009. PMID 19352492, Free PMC Article
    3. Genomic organization, chromosomal localization and tissue specific expression of the murine Pxmp2 gene encoding the 22 kDa peroxisomal membrane protein (Pmp22). Lüers GH, et al. Gene, 2001 Jul 11. PMID 11470509
    4. Differential evolution and expression of murine peroxisomal membrane protein genes. Bryant DD, et al. Biochem Mol Med, 1995 Jun. PMID 7551822
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal membrane protein 2
    Names
    22 kDa peroxisomal membrane protein
    peroxisomal membrane protein 2, 22 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405245.1 → NP_001392174.1  peroxisomal membrane protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC118260

    2. NM_008993.3 → NP_033019.2  peroxisomal membrane protein 2 isoform 1

      See identical proteins and their annotated locations for NP_033019.2

      Status: VALIDATED

      Source sequence(s)
      AC118260
      Consensus CDS
      CCDS19524.1
      UniProtKB/Swiss-Prot
      P42925, Q9ERF1
      UniProtKB/TrEMBL
      Q5D073
      Related
      ENSMUSP00000031472.6, ENSMUST00000031472.12
      Conserved Domains (1) summary
      pfam04117
      Location:129 → 191
      Mpv17_PMP22; Mpv17 / PMP22 family

    RNA

    1. NR_175919.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC118260
      Related
      ENSMUST00000155266.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      110422152..110434036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164916.1 → XP_036020809.1  peroxisomal membrane protein 2 isoform X2

      Conserved Domains (1) summary
      pfam04117
      Location:37 → 98
      Mpv17_PMP22; Mpv17 / PMP22 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42925.2 GenPept UniProtKB/Swiss-Prot:P42925

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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