Ptpn2 protein tyrosine phosphatase, non-receptor type 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptpn2provided by MGI
Official Full Name: protein tyrosine phosphatase, non-receptor type 2provided by MGI
Primary source: MGI:MGI:97806
See related: Ensembl:ENSMUSG00000024539 AllianceGenome:MGI:97806
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ptpt; TC-PTP
Summary: Enables STAT family protein binding activity and protein tyrosine phosphatase activity. Involved in several processes, including hemopoiesis; negative regulation of leukocyte differentiation; and regulation of signal transduction. Acts upstream of or within insulin receptor signaling pathway; negative regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in nucleus. Is active in endosome lumen. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; lower jaw; and midbrain. Orthologous to human PTPN2 (protein tyrosine phosphatase non-receptor type 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 3.3), CNS E14 (RPKM 3.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 40.06 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (67798571..67857697, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (67665501..67724632, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of TCPTP in Macrophages Is Involved in IL-35 Mediated Attenuation of Experimental Colitis.
Title: Upregulation of TCPTP in Macrophages Is Involved in IL-35 Mediated Attenuation of Experimental Colitis.
PTPN2 inhibits the proliferation of psoriatic keratinocytes by dephosphorylation of STAT3.
Title: PTPN2 inhibits the proliferation of psoriatic keratinocytes by dephosphorylation of STAT3.
PTPN2 Regulates Metabolic Flux to Affect beta-Cell Susceptibility to Inflammatory Stress.
Title: PTPN2 Regulates Metabolic Flux to Affect β-Cell Susceptibility to Inflammatory Stress.
DNMT3B activates FGFR3-mediated endoplasmic reticulum stress by regulating PTPN2 promoter methylation to promote the development of atherosclerosis.
Title: DNMT3B activates FGFR3-mediated endoplasmic reticulum stress by regulating PTPN2 promoter methylation to promote the development of atherosclerosis.
PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice.
Title: PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice.
Hypoxia disrupts the nasal epithelial barrier by inhibiting PTPN2 in chronic rhinosinusitis with nasal polyps.
Title: Hypoxia disrupts the nasal epithelial barrier by inhibiting PTPN2 in chronic rhinosinusitis with nasal polyps.
PTPN2 regulates bacterial clearance in a mouse model of enteropathogenic and enterohemorrhagic E. coli infection.
Title: PTPN2 regulates bacterial clearance in a mouse model of enteropathogenic and enterohemorrhagic E. coli infection.
PTPN2 elicits cell autonomous and non-cell autonomous effects on antitumor immunity in triple-negative breast cancer.
Title: PTPN2 elicits cell autonomous and non-cell autonomous effects on antitumor immunity in triple-negative breast cancer.
Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation.
Title: Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation.
Autoimmune susceptibility gene PTPN2 is required for clearance of adherent-invasive Escherichia coli by integrating bacterial uptake and lysosomal defence.
Title: Autoimmune susceptibility gene PTPN2 is required for clearance of adherent-invasive Escherichia coli by integrating bacterial uptake and lysosomal defence.

Submit: New GeneRIF Correction See all GeneRIFs (70)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237830

NoName (e-PCR)
- UniSTS:237831

AI325124 (e-PCR)
- UniSTS:181137

Ptpn2 (e-PCR), detects polymorphism
- UniSTS:536484

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables STAT family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables syntaxin binding	IEA Inferred from Electronic Annotation more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor recycling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-2-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-2-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-4-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-4-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macrophage colony-stimulating factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of platelet-derived growth factor receptor-beta signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of positive thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tyrosine phosphorylation of STAT protein	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-tyrosine dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of PERK-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hepatocyte growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of hepatocyte growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endosome lumen	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 2

Names: MPTP; T cell protein-tyrosine phosphatase; protein-tyrosine phosphatase PTP-2

NP_001120649.1

EC 3.1.3.48

NP_033003.1

EC 3.1.3.48

XP_011245160.1

EC 3.1.3.48

XP_011245161.1

EC 3.1.3.48

XP_030106224.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127177.1 → NP_001120649.1 tyrosine-protein phosphatase non-receptor type 2 isoform b

See identical proteins and their annotated locations for NP_001120649.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longer transcript.

Source sequence(s)

AC108434, AK014528, AK076072, AK132013, CA560046, DV552728

Consensus CDS

CCDS50311.1

UniProtKB/Swiss-Prot

Q06180, Q3V259, Q922E7

UniProtKB/TrEMBL

D3Z6W2

Related

ENSMUSP00000112675.2, ENSMUST00000122412.2

Conserved Domains (2) summary

smart00194
Location:5 → 274

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:45 → 274

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_008977.3 → NP_033003.1 tyrosine-protein phosphatase non-receptor type 2 isoform a

See identical proteins and their annotated locations for NP_033003.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 3' UTR and has multiple coding region differences, compared to variant 2. The resulting protein (isoform a) has a distinct C-terminus and is shorter than isoform b.

Source sequence(s)

AK014528, AK076072, CA560046, DV552728

Consensus CDS

CCDS37851.1

UniProtKB/TrEMBL

D3Z6W2

Related

ENSMUSP00000025420.8, ENSMUST00000025420.14

Conserved Domains (1) summary

cl28904
Location:19 → 272

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

67798571..67857697 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011246858.4 → XP_011245160.1 tyrosine-protein phosphatase non-receptor type 2 isoform X1

See identical proteins and their annotated locations for XP_011245160.1

UniProtKB/TrEMBL

D3Z6W2

Conserved Domains (1) summary

cl28904
Location:19 → 272

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_030250364.2 → XP_030106224.1 tyrosine-protein phosphatase non-receptor type 2 isoform X2

Conserved Domains (1) summary

cl28904
Location:1 → 173

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_011246859.1 → XP_011245161.1 tyrosine-protein phosphatase non-receptor type 2 isoform X2

See identical proteins and their annotated locations for XP_011245161.1

Conserved Domains (1) summary

cl28904
Location:1 → 173

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily