Plb1 phospholipase B1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plb1provided by RGD
Official Full Name: phospholipase B1provided by RGD
Primary source: RGD:621565
See related: EnsemblRapid:ENSRNOG00000026037 AllianceGenome:RGD:621565
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Phlpb
Summary: Enables carboxylic ester hydrolase activity. Involved in glycerolipid catabolic process and retinol metabolic process. Located in brush border membrane. Orthologous to human PLB1 (phospholipase B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 14.1), Testes (RPKM 9.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 62

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (29807127..29945607, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (24087051..24227167, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (25375699..25507108, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH142030 (e-PCR)
- UniSTS:224021

RH130851 (e-PCR)
- UniSTS:214135

BF408487 (e-PCR)
- UniSTS:248760

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-independent phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables lysophospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables lysophospholipase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables phospholipase activity	IEA Inferred from Electronic Annotation more info
enables retinyl-palmitate esterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables retinyl-palmitate esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables triacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in diacylglycerol catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylethanolamine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylglycerol catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of acrosome reaction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of acrosome reaction	ISO Inferred from Sequence Orthology more info
involved_in retinol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in brush border membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phospholipase B1, membrane-associated

Names: PLB/LIP; lysophospholipase; phospholipase A2; phospholipase B; phospholipase B/lipase; triacylglycerol lipase

NP_620253.1

EC 3.1.1.3

EC 3.1.1.4

EC 3.1.1.5

XP_038967688.1

EC 3.1.1.3

EC 3.1.1.4

EC 3.1.1.5

XP_038967691.1

EC 3.1.1.3

EC 3.1.1.4

EC 3.1.1.5

XP_038967692.1

EC 3.1.1.3

EC 3.1.1.4

EC 3.1.1.5

XP_038967693.1

EC 3.1.1.3

EC 3.1.1.4

EC 3.1.1.5

XP_038967694.1

EC 3.1.1.3

EC 3.1.1.4

EC 3.1.1.5

XP_063117606.1

EC 3.1.1.3

EC 3.1.1.4

EC 3.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138898.2 → NP_620253.1 phospholipase B1, membrane-associated precursor

See identical proteins and their annotated locations for NP_620253.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

O54728

UniProtKB/TrEMBL

A6HA29

Related

ENSRNOP00000057888.4, ENSRNOT00000061176.5

Conserved Domains (1) summary

cd01824
Location:387 → 681

Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

29807127..29945607 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261536.1 → XP_063117606.1 phospholipase B1, membrane-associated isoform X1

UniProtKB/Swiss-Prot

O54728
XM_039111764.2 → XP_038967692.1 phospholipase B1, membrane-associated isoform X2

Conserved Domains (1) summary

cd01824
Location:239 → 534

Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...
XM_039111760.1 → XP_038967688.1 phospholipase B1, membrane-associated isoform X2

Conserved Domains (1) summary

cd01824
Location:239 → 534

Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...
XM_039111763.2 → XP_038967691.1 phospholipase B1, membrane-associated isoform X3

Conserved Domains (2) summary

cd01824
Location:154 → 449

Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...

cl01053
Location:1 → 102

SGNH_hydrolase; or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical ...
XM_039111766.1 → XP_038967694.1 phospholipase B1, membrane-associated isoform X5

Conserved Domains (1) summary

cd01824
Location:1 → 273

Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...
XM_039111765.2 → XP_038967693.1 phospholipase B1, membrane-associated isoform X4

Conserved Domains (2) summary

cd01824
Location:387 → 681

Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...

cl01053
Location:733 → 777

SGNH_hydrolase; or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the typical ...