Pja2 praja ring finger ubiquitin ligase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pja2provided by RGD
Official Full Name: praja ring finger ubiquitin ligase 2provided by RGD
Primary source: RGD:620273
See related: EnsemblRapid:ENSRNOG00000015528 AllianceGenome:RGD:620273
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: praja2; Neurodap1
Summary: Predicted to enable protein kinase A catalytic subunit binding activity; protein kinase A regulatory subunit binding activity; and ubiquitin protein ligase activity. Involved in long-term memory and regulation of protein kinase A signaling. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human PJA2 (praja ring finger ubiquitin ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 939.4), Heart (RPKM 310.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q37

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (111403624..111453703, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (103956678..104006763, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (111998204..112048847, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that praja2 regulates the stability and total concentration of protein kinase A R subunits, tuning the strength and duration of PKA signal output in response to cAMP.
Title: Control of PKA stability and signalling by the RING ligase praja2.

Submit: New GeneRIF Correction

General gene information

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Markers

RH144228 (e-PCR)
- UniSTS:233473

RH133870 (e-PCR)
- UniSTS:217153

AI447901 (e-PCR)
- UniSTS:160683

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A catalytic subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of toll-like receptor 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 2 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein kinase A signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase Praja-2

Names: RING-type E3 ubiquitin transferase Praja-2; praja 2, RING-H2 motif containing; praja ring finger 2, E3 ubiquitin protein ligase; protein carrying the RING-H2 sequence motif

NP_001264207.1

EC 2.3.2.27

NP_620251.1

EC 2.3.2.27

XP_017451755.1

EC 2.3.2.27

XP_063122694.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277278.1 → NP_001264207.1 E3 ubiquitin-protein ligase Praja-2 isoform 2

See identical proteins and their annotated locations for NP_001264207.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

BC074015, CB577390, JAXUCZ010000009

UniProtKB/TrEMBL

A0A0H2UHM9, A6JRB0

Related

ENSRNOP00000021258.5, ENSRNOT00000021258.9

Conserved Domains (1) summary

pfam13639
Location:571 → 612

zf-RING_2; Ring finger domain
NM_138896.2 → NP_620251.1 E3 ubiquitin-protein ligase Praja-2 isoform 1

See identical proteins and their annotated locations for NP_620251.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC074015, CB577390, JAXUCZ010000009

UniProtKB/Swiss-Prot

Q63364

UniProtKB/TrEMBL

A6JRB1

Related

ENSRNOP00000072362.1, ENSRNOT00000080962.3

Conserved Domains (3) summary

PRK11151
Location:210 → 241

PRK11151; DNA-binding transcriptional regulator OxyR; Provisional

COG5271
Location:269 → 628

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd16465
Location:632 → 677

RING-H2_PJA1_2; RING finger, H2 subclass, found in protein E3 ubiquitin-protein ligase Praja-1, Praja-2, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

111403624..111453703 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266624.1 → XP_063122694.1 E3 ubiquitin-protein ligase Praja-2 isoform X2

UniProtKB/TrEMBL

A0A0H2UHM9, A6JRB0
XM_017596266.2 → XP_017451755.1 E3 ubiquitin-protein ligase Praja-2 isoform X1

UniProtKB/Swiss-Prot

Q63364

UniProtKB/TrEMBL

A6JRB1

Conserved Domains (3) summary

PRK11151
Location:210 → 241

PRK11151; DNA-binding transcriptional regulator OxyR; Provisional

COG5271
Location:269 → 628

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

cd16465
Location:632 → 677

RING-H2_PJA1_2; RING finger, H2 subclass, found in protein E3 ubiquitin-protein ligase Praja-1, Praja-2, and similar proteins