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    Prpf4b pre-mRNA processing factor 4B [ Mus musculus (house mouse) ]

    Gene ID: 19134, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Prpf4bprovided by MGI
    Official Full Name
    pre-mRNA processing factor 4Bprovided by MGI
    Primary source
    MGI:MGI:109584
    See related
    Ensembl:ENSMUSG00000021413 AllianceGenome:MGI:109584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prp4; Prpk; Prp4k; cbp143; 2610037H07
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in positive regulation of protein export from nucleus; regulation of intracellular signal transduction; and spliceosomal tri-snRNP complex assembly. Located in chromosome. Is expressed in several structures, including cerebral cortex; early conceptus; oocyte; and pancreas epithelium. Orthologous to human PRP4K (pre-mRNA processing factor kinase PRP4K). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 19.1), limb E14.5 (RPKM 16.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prpf4b in Genome Data Viewer
    Location:
    13 A3.3; 13 14.21 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (35058803..35090047)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (34874820..34906064)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 50, member B Neighboring gene STARR-positive B cell enhancer ABC_E4064 Neighboring gene VISTA enhancer mm180 Neighboring gene STARR-positive B cell enhancer ABC_E11539 Neighboring gene STARR-positive B cell enhancer ABC_E7222 Neighboring gene STARR-positive B cell enhancer ABC_E7223 Neighboring gene ribosomal protein S4, X-linked pseudogene Neighboring gene predicted gene, 36839 Neighboring gene STARR-seq mESC enhancer starr_34164 Neighboring gene family with sequence similarity 217, member A Neighboring gene testis expressed 56 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue. Gross T, et al. Nucleic Acids Res, 1997 Mar 1. PMID 9102632, Free PMC Article
    2. Cloning of human PRP4 reveals interaction with Clk1. Kojima T, et al. J Biol Chem, 2001 Aug 24. PMID 11418604
    3. Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. Dellaire G, et al. Mol Cell Biol, 2002 Jul. PMID 12077342, Free PMC Article
    4. Capturing novel mouse genes encoding chromosomal and other nuclear proteins. Tate P, et al. J Cell Sci, 1998 Sep. PMID 9701556
    5. Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development. Kumar A, et al. Int J Dev Neurosci, 2014 Nov. PMID 25196998

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.
      Title: Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC5960

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of hippo signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal snRNP assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PRP4 homolog
    Names
    PRP4 pre-mRNA processing factor 4 homolog B
    PRP4 pre-mRNA-processing factor 4 homolog
    pre-mRNA protein kinase
    NP_038858.2
    XP_006516645.1
    XP_006516647.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013830.3 → NP_038858.2  serine/threonine-protein kinase PRP4 homolog

      See identical proteins and their annotated locations for NP_038858.2

      Status: VALIDATED

      Source sequence(s)
      AC124537, AC132344
      Consensus CDS
      CCDS26448.1
      UniProtKB/Swiss-Prot
      B2RUN6, O88378, Q61136, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0
      UniProtKB/TrEMBL
      C7G3P2
      Related
      ENSMUSP00000077019.4, ENSMUST00000077853.5
      Conserved Domains (2) summary
      PTZ00449
      Location:171 → 393
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd14135
      Location:686 → 1003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

    RNA

    1. NR_165078.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124537, AC132344

    2. NR_165079.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124537, AC132344

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      35058803..35090047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516584.4 → XP_006516647.1  serine/threonine-protein kinase PRP4 homolog isoform X2

      UniProtKB/TrEMBL
      C7G3P2
      Conserved Domains (2) summary
      PTZ00449
      Location:171 → 393
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl21453
      Location:686 → 860
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006516582.4 → XP_006516645.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/TrEMBL
      C7G3P2
      Conserved Domains (2) summary
      PTZ00449
      Location:171 → 393
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cl21453
      Location:686 → 860
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_004937977.1 RNA Sequence

    2. XR_004937978.1 RNA Sequence

    3. XR_004937979.1 RNA Sequence

    4. XR_004937980.1 RNA Sequence

    5. XR_004937976.1 RNA Sequence

    6. XR_004937974.1 RNA Sequence

    7. XR_004937975.1 RNA Sequence

    8. XR_004937968.1 RNA Sequence

    9. XR_004937969.1 RNA Sequence

    10. XR_004937970.1 RNA Sequence

    11. XR_004937971.1 RNA Sequence

    12. XR_004937972.1 RNA Sequence

    13. XR_004937973.1 RNA Sequence

    14. XR_004937966.1 RNA Sequence

    15. XR_004937967.1 RNA Sequence

    16. XR_004937946.1 RNA Sequence

    17. XR_004937950.1 RNA Sequence

    18. XR_004937956.1 RNA Sequence

    19. XR_004937945.1 RNA Sequence

    20. XR_004937949.1 RNA Sequence

    21. XR_004937954.1 RNA Sequence

    22. XR_004937958.1 RNA Sequence

    23. XR_004937952.1 RNA Sequence

    24. XR_004937953.1 RNA Sequence

    25. XR_004937947.1 RNA Sequence

    26. XR_004937955.1 RNA Sequence

    27. XR_004937962.1 RNA Sequence

    28. XR_004937948.1 RNA Sequence

    29. XR_004937951.1 RNA Sequence

    30. XR_004937957.1 RNA Sequence

    31. XR_004937960.1 RNA Sequence

    32. XR_004937959.1 RNA Sequence

    33. XR_004937961.1 RNA Sequence

    34. XR_004937963.1 RNA Sequence

    35. XR_004937964.1 RNA Sequence

    36. XR_004937965.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61136.3 GenPept UniProtKB/Swiss-Prot:Q61136

    Gene LinkOut

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