hsd-1 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: hsd-1
Official Full Name: 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1
Primary source: WormBase:WBGene00012394
Locus tag: CELE_Y6B3B.11
See related: AllianceGenome:WB:WBGene00012394
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables 3-beta-hydroxy-delta5-steroid dehydrogenase activity. Involved in nematode larval development and sterol biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in XXXL and XXXR. Orthologous to human SDR42E1 (short chain dehydrogenase/reductase family 42E, member 1) and SDR42E2 (short chain dehydrogenase/reductase family 42E, member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

HSD-1-mediated signal activates insulin/IGF-I signaling in a cell non-autonomous fashion
Title: Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans.

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Function	Evidence Code	Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cholesterol dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables steroid delta-isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

Preferred Names: 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1

NP_493402.1

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