Bpifa1 BPI fold containing family A, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bpifa1provided by MGI
Official Full Name: BPI fold containing family A, member 1provided by MGI
Primary source: MGI:MGI:1338036
See related: Ensembl:ENSMUSG00000027483 AllianceGenome:MGI:1338036
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LUNX; NASG; Plunc; SPURT; SPLUNC1
Summary: Predicted to enable lipid binding activity. Involved in antibacterial humoral response; innate immune response; and negative regulation of single-species biofilm formation in or on host organism. Predicted to be located in extracellular region and microvillus. Predicted to be active in extracellular space. Is expressed in hemolymphoid system; nose; respiratory system; and turbinate bone. Used to study otitis media. Orthologous to human BPIFA1 (BPI fold containing family A member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 182.2) and heart adult (RPKM 116.8) See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 76.15 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (153984800..153991137)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (154142880..154149217)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CC16 drives VLA-2-dependent SPLUNC1 expression.
Title: CC16 drives VLA-2-dependent SPLUNC1 expression.
Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) level determines steroid-resistant airway inflammation in aging.
Title: Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) level determines steroid-resistant airway inflammation in aging.
The SPLUNC1-betaENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia.
Title: The SPLUNC1-βENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia.
identify a novel role for Bpifa1 in the regulation of Cxcl10-mediated polymorphonuclear cell recruitment to the lungs via IFNgamma and -lambda signaling during acute inflammation
Title: BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation.
Bpifa1-deficient (Bpifa1-/-) mice exhibited spontaneous airway hyperresponsiveness and that excised tracheas from Bpifa1+/+ but not Bpifa1-/- mice were capable of reducing airway smooth muscle contraction.
Title: Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor.
this study shows that BPIFA1/SPLUNC1 restricts influenza A virus infection
Title: An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection.
SPLUNC1-knockout mice was established in a LPS-induced acute lung injury (ALI) mouse model to study the anti-inflammatory effect of SPLUNC1. Results found that SPLUNC1 deficiency upregulated levels of ALI-related cytokines leading to more severe lung injury after LPS injection. Moreover, further data discovered that the presence of SPLUNC1 can suppress the recruitment of CD11b+Gr-1+ MDSCs to the spleen in LPS-induced ALI.
Title: SPLUNC1 knockout enhances LPS-induced lung injury by increasing recruitment of CD11b+Gr-1+ cells to the spleen of mice.
Loss of Splunc1 predisposes mice to the development of otitis media.
Title: Increased susceptibility to otitis media in a Splunc1-deficient mouse model.
SPLUNC1 is a crucial component of mucosal innate immune defense against pulmonary infection.
Title: SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection.
Knowledge of the complex expression patterns of BPIF proteins in these regions will allow the use of tractable mouse models of disease to dissect their function.
Title: Differential localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antibacterial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response in nasopharyngeal-associated lymphoid tissue	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level water homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of single-species biofilm formation in or on host organism	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of single-species biofilm formation in or on host organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of single-species biofilm formation in or on host organism	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in surfactant homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in surfactant homeostasis	ISO Inferred from Sequence Orthology more info
involved_in surfactant homeostasis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BPI fold-containing family A member 1

Names: palate lung and nasal epithelium clone protein; palate, lung, and nasal epithelium associated; palate, lung, and nasal epithelium clone; palate, lung, and nasal epithelium expressed transcript; protein Plunc

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.