Per2 period circadian clock 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Per2provided by MGI
Official Full Name: period circadian clock 2provided by MGI
Primary source: MGI:MGI:1195265
See related: Ensembl:ENSMUSG00000055866 AllianceGenome:MGI:1195265
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mPer2; mKIAA0347
Summary: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
Expression: Ubiquitous expression in adrenal adult (RPKM 15.3), bladder adult (RPKM 12.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 46.13 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (91343699..91387028, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (91415977..91459351, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells.
Title: Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells.
Clock gene Per2 modulates epidermal tissue repair in vivo.
Title: Clock gene Per2 modulates epidermal tissue repair in vivo.
Importance of Per2 in cardiac mitochondrial protection during stress.
Title: Importance of Per2 in cardiac mitochondrial protection during stress.
Circadian ribosome profiling reveals a role for the Period2 upstream open reading frame in sleep.
Title: Circadian ribosome profiling reveals a role for the Period2 upstream open reading frame in sleep.
The differential vulnerabilities of Per2 knockout mice to the addictive properties of methamphetamine and cocaine.
Title: The differential vulnerabilities of Per2 knockout mice to the addictive properties of methamphetamine and cocaine.
Circadian regulation of mTORC1 signaling via Per2 dependent mechanism disrupts folliculogenesis and oocyte maturation in female mice.
Title: Circadian regulation of mTORC1 signaling via Per2 dependent mechanism disrupts folliculogenesis and oocyte maturation in female mice.
Heat shock factor 1 induces a short burst of transcription of the clock gene Per2 during interbout arousal in mammalian hibernation.
Title: Heat shock factor 1 induces a short burst of transcription of the clock gene Per2 during interbout arousal in mammalian hibernation.
Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm.
Title: Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm.
Adrenalectomy prevents the effects of social defeat stress on PER2 rhythms in some peripheral tissues in male mice.
Title: Adrenalectomy prevents the effects of social defeat stress on PER2 rhythms in some peripheral tissues in male mice.
Endogenous circadian reporters reveal functional differences of PERIOD paralogs and the significance of PERIOD:CK1 stable interaction.
Title: Endogenous circadian reporters reveal functional differences of PERIOD paralogs and the significance of PERIOD:CK1 stable interaction.

Submit: New GeneRIF Correction See all GeneRIFs (246)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (12) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC124275P1 (e-PCR)
- UniSTS:270459

Per2 (e-PCR), detects polymorphism
- UniSTS:547572

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone methyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables pre-mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of gene expression	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lactate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of circadian rhythm	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of fat cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of termination of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription regulatory region DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glutamate uptake involved in transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ischemia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in white fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cry-Per complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: period circadian protein homolog 2

Names: circadian clock protein PERIOD 2; period 2; period homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001420881.1 → NP_001407810.1 period circadian protein homolog 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC109199, AC110510
NM_011066.4 → NP_035196.2 period circadian protein homolog 2 isoform 1

See identical proteins and their annotated locations for NP_035196.2

Status: VALIDATED

Source sequence(s)

AC109199, AC110510

Consensus CDS

CCDS35663.1

UniProtKB/TrEMBL

A0A0R4J0U3, Q3TN36

Related

ENSMUSP00000066620.9, ENSMUST00000069620.10

Conserved Domains (3) summary

cd00130
Location:330 → 432

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:344 → 428

PAS_3; PAS fold

pfam12114
Location:1040 → 1234

Period_C; Period protein 2/3C-terminal region

RNA

NR_185210.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC109199, AC110510

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

91343699..91387028 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529250.5 → XP_006529313.1 period circadian protein homolog 2 isoform X2

UniProtKB/TrEMBL

Q3TN36

Conserved Domains (4) summary

PHA03247
Location:649 → 897

PHA03247; large tegument protein UL36; Provisional

PRK10263
Location:304 → 841

PRK10263; DNA translocase FtsK; Provisional

pfam08447
Location:203 → 287

PAS_3; PAS fold

pfam12114
Location:899 → 1093

Period_C; Period protein 2/3C-terminal region