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    Nsg2 neuron specific gene family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 18197, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nsg2provided by MGI
    Official Full Name
    neuron specific gene family member 2provided by MGI
    Primary source
    MGI:MGI:1202070
    See related
    Ensembl:ENSMUSG00000020297 AllianceGenome:MGI:1202070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P19
    Summary
    Predicted to enable clathrin light chain binding activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Located in Golgi cis cisterna membrane and multivesicular body membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including axial skeleton; intestine; nasal epithelium; nervous system; and retina. Orthologous to human NSG2 (neuronal vesicle trafficking associated 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 228.8), whole brain E14.5 (RPKM 160.1) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nsg2 in Genome Data Viewer
    Location:
    11 A4; 11 18.72 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (31949678..32009211)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (31999704..32059211)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930524B15 gene Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29098 Neighboring gene STARR-seq mESC enhancer starr_29099 Neighboring gene predicted gene, 35267 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:31899676-31899877 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:31899887-31900116 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:31968884-31969085 Neighboring gene STARR-seq mESC enhancer starr_29101 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:32006435-32006636 Neighboring gene predicted gene 12108 Neighboring gene predicted gene, 39676 Neighboring gene predicted gene, 51888

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Assignment of the human 8.5 H gene to chromosome 5, region 5q35. Diriong S, et al. Hum Genet, 1994 Jun. PMID 8005598
    2. Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission. Chander P, et al. eNeuro, 2019 Jan-Feb. PMID 30680309, Free PMC Article
    3. Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Ueda T, et al. Blood, 2015 May 28. PMID 25872778, Free PMC Article
    4. A 19-kDa protein belonging to a new family is expressed in the Golgi apparatus of neural cells. Sabéran-Djoneidi D, et al. J Biol Chem, 1995 Jan 27. PMID 7829526
    5. The related neuronal endosomal proteins NEEP21 (Nsg1) and P19 (Nsg2) have divergent expression profiles in vivo. Barford K, et al. J Comp Neurol, 2017 Jun 1. PMID 28299779, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NSG2 is found in discrete punctae restricted to the somatodendritic arbors of developing mouse and human neurons, and a significant proportion of NSG2 punctae colocalize with postsynaptic HOMER1 and surface-expressed AMPA-type glutamate receptors (AMPARs) at excitatory synapses.
      Title: Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission.
    2. we show that NEEP21/Nsg1 and P19/Nsg2 are present in both overlapping and distinct cell populations in the hippocampus, neocortex, and cerebellum during development.
      Title: The related neuronal endosomal proteins NEEP21 (Nsg1) and P19 (Nsg2) have divergent expression profiles in vivo.
    3. Fbxl10 is a bona fide oncogene, whose deregulated expression contributes to the development of leukemia involving metabolic proliferative advantage and Nsg2-mediated impaired differentiation.
      Title: Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin light chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin coat assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin coat assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cis cisterna membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in multivesicular body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    neuronal vesicle trafficking-associated protein 2
    Names
    neuron-specific protein family member 2
    protein 8.5
    protein p19

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290680.1 → NP_001277609.1  neuronal vesicle trafficking-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001277609.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AK075612, BM114408, BU058771, CO040919
      Consensus CDS
      CCDS24516.1
      UniProtKB/Swiss-Prot
      P47759
      UniProtKB/TrEMBL
      Q5SS02
      Conserved Domains (1) summary
      pfam06387
      Location:1 → 169
      Calcyon; D1 dopamine receptor-interacting protein (calcyon)

    2. NM_001290681.1 → NP_001277610.1  neuronal vesicle trafficking-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001277610.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AK075612, AL669946, BM114408, CD352422, CO040919
      Consensus CDS
      CCDS24516.1
      UniProtKB/Swiss-Prot
      P47759
      UniProtKB/TrEMBL
      Q5SS02
      Conserved Domains (1) summary
      pfam06387
      Location:1 → 169
      Calcyon; D1 dopamine receptor-interacting protein (calcyon)

    3. NM_001347080.1 → NP_001334009.1  neuronal vesicle trafficking-associated protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 3' terminal exon, resulting in novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK041338, DN176718
      Consensus CDS
      CCDS88140.1
      UniProtKB/TrEMBL
      Q5SS03
      Related
      ENSMUSP00000090907.4, ENSMUST00000093219.4
      Conserved Domains (1) summary
      pfam06387
      Location:1 → 74
      Calcyon; D1 dopamine receptor-interacting protein (calcyon)

    4. NM_008741.4 → NP_032767.1  neuronal vesicle trafficking-associated protein 2 isoform 1

      See identical proteins and their annotated locations for NP_032767.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AK075612, BM114408, CO040919, DN176718
      Consensus CDS
      CCDS24516.1
      UniProtKB/Swiss-Prot
      P47759
      UniProtKB/TrEMBL
      Q5SS02
      Related
      ENSMUSP00000020537.3, ENSMUST00000020537.9
      Conserved Domains (1) summary
      pfam06387
      Location:1 → 169
      Calcyon; D1 dopamine receptor-interacting protein (calcyon)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      31949678..32009211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245647.2 → XP_030101507.1  neuronal vesicle trafficking-associated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      P47759
      UniProtKB/TrEMBL
      Q5SS02
      Conserved Domains (1) summary
      pfam06387
      Location:1 → 169
      Calcyon; D1 dopamine receptor-interacting protein (calcyon)

    2. XM_036156412.1 → XP_036012305.1  neuronal vesicle trafficking-associated protein 2 isoform X2

      UniProtKB/TrEMBL
      Q5SS03
      Conserved Domains (1) summary
      pfam06387
      Location:1 → 74
      Calcyon; D1 dopamine receptor-interacting protein (calcyon)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47759.1 GenPept UniProtKB/Swiss-Prot:P47759

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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