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    sax-1 Serine/threonine-protein kinase sax-1 [ Caenorhabditis elegans ]

    Gene ID: 180655, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sax-1
    Official Full Name
    Serine/threonine-protein kinase sax-1
    Primary source
    WormBase:WBGene00004727
    Locus tag
    CELE_R11G1.4
    See related
    AllianceGenome:WB:WBGene00004727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of cell growth; neuron projection development; and regulation of cell shape. Located in several cellular components, including axon; dendrite; and nucleus. Is expressed in hypodermis; muscle cell; and nerve ring. Orthologous to several human genes including STK38 (serine/threonine kinase 38). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See sax-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (3646318..3650150, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Glutathione S-Transferase Neighboring gene C2 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanosensory neurite termination and tiling depend on SAX-2 and the SAX-1 kinase. Gallegos ME, et al. Neuron, 2004 Oct 14. PMID 15473964
    2. A Neurexin-related protein, BAM-2, terminates axonal branches in C. elegans. Colavita A, et al. Science, 2003 Oct 10. PMID 14551437
    3. Expression of thioredoxin-1 in the ASJ neuron corresponds with and enhances intrinsic regenerative capacity under lesion conditioning in C. elegans. Grooms NWF, et al. FEBS Lett, 2023 Jul. PMID 37300530, Free PMC Article
    4. Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging. Ogura M, et al. EMBO Rep, 2023 Dec 6. PMID 37987447, Free PMC Article
    5. Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family. Zallen JA, et al. Mol Biol Cell, 2000 Sep. PMID 10982409, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell projection assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein kinase sax-1
    NP_001024858.2
    • Confirmed by transcript evidence
    NP_508627.5
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3646318..3650150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029687.7 → NP_001024858.2  Serine/threonine-protein kinase sax-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024858.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2L6W9
      Conserved Domains (2) summary
      smart00220
      Location:87 → 381
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05599
      Location:85 → 443
      STKc_NDR_like; Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases

    2. NM_076226.6 → NP_508627.5  Serine/threonine-protein kinase sax-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508627.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21613, Q21946, Q2L6W9, Q2L6X0, Q9NB00
      Conserved Domains (2) summary
      smart00220
      Location:87 → 381
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05599
      Location:85 → 443
      STKc_NDR_like; Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2L6W9.1

    Gene LinkOut

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