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    Nfix nuclear factor I/X [ Mus musculus (house mouse) ]

    Gene ID: 18032, updated on 12-Nov-2024

    Summary

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    Official Symbol
    Nfixprovided by MGI
    Official Full Name
    nuclear factor I/Xprovided by MGI
    Primary source
    MGI:MGI:97311
    See related
    Ensembl:ENSMUSG00000001911 AllianceGenome:MGI:97311
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CTF; NF1-X; NFI-X; NF-I/X
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including learning or memory; nervous system development; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including exit from mitosis; myeloid leukocyte differentiation; and nervous system development. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study Scheuermann's disease and Sotos syndrome 2. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome and Sotos syndrome 2. Orthologous to human NFIX (nuclear factor I X). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 15.5), limb E14.5 (RPKM 14.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nfix in Genome Data Viewer
    Location:
    8 C3; 8 41.02 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85431341..85527086, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84704712..84801238, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87188874-87189057 Neighboring gene predicted gene, 26664 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing Neighboring gene STARR-positive B cell enhancer ABC_E6667 Neighboring gene STARR-positive B cell enhancer ABC_E5026 Neighboring gene tRNA methyltransferase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87228416-87228525 Neighboring gene RIKEN cDNA G430095P16 gene Neighboring gene lymphoblastomic leukemia 1 Neighboring gene VISTA enhancer mm21 Neighboring gene VISTA enhancer mm1615 Neighboring gene STARR-seq mESC enhancer starr_22139 Neighboring gene DAN domain family member 5, BMP antagonist Neighboring gene growth arrest and DNA-damage-inducible, gamma interacting protein 1 Neighboring gene RAD23 homolog A, nucleotide excision repair protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of cellular retinoic acid binding protein 2 (CRABP2) as downstream target of nuclear factor I/X (NFIX): implications for skeletal dysplasia syndromes. Kooblall KG, et al. JBMR Plus, 2024 Jul. PMID 38827116, Free PMC Article
    2. Nfix expression critically modulates early B lymphopoiesis and myelopoiesis. O'Connor C, et al. PLoS One, 2015. PMID 25780920, Free PMC Article
    3. Loss of NFIX Transcription Factor Biases Postnatal Neural Stem/Progenitor Cells Toward Oligodendrogenesis. Zhou B, et al. Stem Cells Dev, 2015 Sep 15. PMID 26083238
    4. Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival. Holmfeldt P, et al. Blood, 2013 Oct 24. PMID 24041575, Free PMC Article
    5. Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence. Martynoga B, et al. Genes Dev, 2013 Aug 15. PMID 23964093, Free PMC Article

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Function and regulation of nuclear factor 1 X-type on chondrocyte proliferation and differentiation.
      Title: Function and regulation of nuclear factor 1 X-type on chondrocyte proliferation and differentiation.
    2. Hydrocephalus in Nfix(-/-) Mice Is Underpinned by Changes in Ependymal Cell Physiology.
      Title: Hydrocephalus in Nfix(-/-) Mice Is Underpinned by Changes in Ependymal Cell Physiology.
    3. Deletion of NFIX results in defective progression through meiosis within the mouse testisdagger.
      Title: Deletion of NFIX results in defective progression through meiosis within the mouse testis†.
    4. Selective ablation of Nfix in macrophages attenuates muscular dystrophy by inhibiting fibro-adipogenic progenitor-dependent fibrosis.
      Title: Selective ablation of Nfix in macrophages attenuates muscular dystrophy by inhibiting fibro-adipogenic progenitor-dependent fibrosis.
    5. High-mobility group AT-Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling.
      Title: High-mobility group AT-Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling.
    6. Temporarily Epigenetic Repression in Bergmann Glia Regulates the Migration of Granule Cells.
      Title: Temporarily Epigenetic Repression in Bergmann Glia Regulates the Migration of Granule Cells.
    7. The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration.
      Title: The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration.
    8. MicroRNA-25-3p regulates osteoclasts through nuclear factor I X.
      Title: MicroRNA-25-3p regulates osteoclasts through nuclear factor I X.
    9. Removal of Nfix gene from either neural stem and progenitor cells, or neuroblasts, within the ventricular-subventricular zone culminated in neuroblast migration defects. Mechanistically, we identified aberrant neuroblast branching, due in part to increased expression of the guanylyl cyclase natriuretic peptide receptor 2 (Npr2), as a factor contributing to abnormal migration in Nfix-deficient adult mice.
      Title: NFIX-Mediated Inhibition of Neuroblast Branching Regulates Migration Within the Adult Mouse Ventricular-Subventricular Zone.
    10. The NFI transcription factors (Nfia, Nfib, and Nfix) are selectively expressed in late retinal progenitor cells and they control bipolar interneuron and Muller glia cell fate specification and promote proliferative quiescence.
      Title: Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification.
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within astrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in astrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in atrioventricular canal morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within brain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell proliferation in forebrain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell proliferation in forebrain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell quiescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell quiescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to BMP stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cerebellar Purkinje cell layer development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cerebellar cortex morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cerebellar granule cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cerebellar granule cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cerebellum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within collateral sprouting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ear development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endochondral ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in forebrain radial glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within generation of neurons IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glial cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gliogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gliogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lateral ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lateral ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in olfactory bulb development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoclast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal muscle satellite cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spinal cord development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nuclear factor 1 X-type
    Names
    CCAAT-box-binding transcription factor
    TGGCA-binding protein
    nuclear factor 1/X

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081981.3 → NP_001075450.1  nuclear factor 1 X-type isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes isoform 3.
      Source sequence(s)
      AC145556, AC155163
      Consensus CDS
      CCDS40411.1
      UniProtKB/TrEMBL
      E9PUH7, Q5CZY4
      Related
      ENSMUSP00000105386.2, ENSMUST00000109764.8
      Conserved Domains (3) summary
      pfam00859
      Location:205 → 494
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:2 → 38
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:60 → 162
      MH1; N-terminal Mad Homology 1 (MH1) domain

    2. NM_001081982.3 → NP_001075451.1  nuclear factor 1 X-type isoform 1

      See identical proteins and their annotated locations for NP_001075451.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 3. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 3.
      Source sequence(s)
      AC145556, AC155163
      Consensus CDS
      CCDS40413.1
      UniProtKB/Swiss-Prot
      O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
      UniProtKB/TrEMBL
      D3YZ00
      Related
      ENSMUSP00000096669.4, ENSMUST00000099070.10
      Conserved Domains (3) summary
      pfam00859
      Location:213 → 418
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:9 → 46
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:68 → 170
      MH1; N-terminal Mad Homology 1 (MH1) domain

    3. NM_001297601.2 → NP_001284530.1  nuclear factor 1 X-type isoform 4

      See identical proteins and their annotated locations for NP_001284530.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and another alternate exon compared to variant 3, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 3.
      Source sequence(s)
      AC145556, AC155163
      Consensus CDS
      CCDS80907.1
      UniProtKB/TrEMBL
      Q3TYK3
      Related
      ENSMUSP00000105384.2, ENSMUST00000109762.8
      Conserved Domains (3) summary
      pfam00859
      Location:205 → 368
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:2 → 38
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:60 → 162
      MH1; N-terminal Mad Homology 1 (MH1) domain

    4. NM_001371052.1 → NP_001357981.1  nuclear factor 1 X-type isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes the longest isoform (5).
      Source sequence(s)
      AC145556, AC155163
      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (3) summary
      pfam00859
      Location:216 → 505
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:13 → 49
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:71 → 173
      MH1; N-terminal Mad Homology 1 (MH1) domain

    5. NM_001371053.1 → NP_001357982.1  nuclear factor 1 X-type isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC145556, AC155163
      UniProtKB/TrEMBL
      D3YZ00
      Conserved Domains (3) summary
      pfam10524
      Location:9 → 46
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:213 → 502
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:68 → 170
      MH1; N-terminal Mad Homology 1 (MH1) domain

    6. NM_001371054.1 → NP_001357983.1  nuclear factor 1 X-type isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC145556, AC155163
      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (3) summary
      pfam10524
      Location:6 → 42
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:209 → 498
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:64 → 166
      MH1; N-terminal Mad Homology 1 (MH1) domain

    7. NM_001371055.1 → NP_001357984.1  nuclear factor 1 X-type isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC145556, AC155163
      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (3) summary
      pfam00859
      Location:205 → 453
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:2 → 38
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:60 → 162
      MH1; N-terminal Mad Homology 1 (MH1) domain

    8. NM_001371056.1 → NP_001357985.1  nuclear factor 1 X-type isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC145556, AC155163
      UniProtKB/Swiss-Prot
      O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
      UniProtKB/TrEMBL
      D3YZ00
      Conserved Domains (3) summary
      pfam00859
      Location:216 → 421
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:9 → 49
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:71 → 173
      MH1; N-terminal Mad Homology 1 (MH1) domain

    9. NM_001371057.1 → NP_001357986.1  nuclear factor 1 X-type isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC145556, AC155163
      UniProtKB/Swiss-Prot
      O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
      UniProtKB/TrEMBL
      D3YZ00
      Conserved Domains (3) summary
      pfam00859
      Location:205 → 410
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:2 → 38
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:60 → 162
      MH1; N-terminal Mad Homology 1 (MH1) domain

    10. NM_001371058.1 → NP_001357987.1  nuclear factor 1 X-type isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC145556, AC155163
      UniProtKB/Swiss-Prot
      O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
      UniProtKB/TrEMBL
      D3YZ00
      Conserved Domains (3) summary
      pfam00859
      Location:205 → 409
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:2 → 38
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:60 → 162
      MH1; N-terminal Mad Homology 1 (MH1) domain

    11. NM_001371059.1 → NP_001357988.1  nuclear factor 1 X-type isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC145556, AC155163
      UniProtKB/Swiss-Prot
      O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
      UniProtKB/TrEMBL
      D3YZ00
      Conserved Domains (3) summary
      pfam00859
      Location:209 → 414
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:6 → 42
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:64 → 166
      MH1; N-terminal Mad Homology 1 (MH1) domain

    12. NM_001371060.1 → NP_001357989.1  nuclear factor 1 X-type isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC145556, AC155163
      Conserved Domains (2) summary
      pfam00859
      Location:166 → 370
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    13. NM_001371061.1 → NP_001357990.1  nuclear factor 1 X-type isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC145556, AC155163
      Conserved Domains (3) summary
      pfam00859
      Location:205 → 382
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:2 → 38
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:60 → 162
      MH1; N-terminal Mad Homology 1 (MH1) domain

    14. NM_001371062.1 → NP_001357991.1  nuclear factor 1 X-type isoform 15

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variant 16, encodes isoform 15.
      Source sequence(s)
      AC145556, AC155163
      Conserved Domains (2) summary
      pfam00859
      Location:166 → 371
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    15. NM_001371063.1 → NP_001357992.1  nuclear factor 1 X-type isoform 15

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variant 15, encodes isoform 15.
      Source sequence(s)
      AC145556, AC155163
      Conserved Domains (2) summary
      pfam00859
      Location:166 → 371
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    16. NM_010906.4 → NP_035036.1  nuclear factor 1 X-type isoform 2

      See identical proteins and their annotated locations for NP_035036.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 3. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 3.
      Source sequence(s)
      AC145556, AC155163
      Consensus CDS
      CCDS40412.1
      UniProtKB/Swiss-Prot
      P70257
      UniProtKB/TrEMBL
      Q3TYK3, Q5CZY4
      Related
      ENSMUSP00000076005.7, ENSMUST00000076715.13
      Conserved Domains (3) summary
      pfam00859
      Location:213 → 390
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:9 → 46
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:68 → 170
      MH1; N-terminal Mad Homology 1 (MH1) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85431341..85527086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153804.1 → XP_036009697.1  nuclear factor 1 X-type isoform X15

      UniProtKB/Swiss-Prot
      O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
      UniProtKB/TrEMBL
      D3YZ00
      Conserved Domains (3) summary
      pfam10524
      Location:9 → 46
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:213 → 418
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:68 → 170
      MH1; N-terminal Mad Homology 1 (MH1) domain

    2. XM_036153796.1 → XP_036009689.1  nuclear factor 1 X-type isoform X5

      Conserved Domains (2) summary
      pfam00859
      Location:166 → 371
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    3. XM_036153797.1 → XP_036009690.1  nuclear factor 1 X-type isoform X6

      Conserved Domains (2) summary
      pfam00859
      Location:166 → 370
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    4. XM_036153805.1 → XP_036009698.1  nuclear factor 1 X-type isoform X16

      UniProtKB/Swiss-Prot
      O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
      UniProtKB/TrEMBL
      D3YZ00
      Conserved Domains (3) summary
      pfam10524
      Location:2 → 38
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:205 → 410
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:60 → 162
      MH1; N-terminal Mad Homology 1 (MH1) domain

    5. XM_036153799.1 → XP_036009692.1  nuclear factor 1 X-type isoform X10

      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (3) summary
      pfam10524
      Location:6 → 42
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:209 → 498
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:64 → 166
      MH1; N-terminal Mad Homology 1 (MH1) domain

    6. XM_036153802.1 → XP_036009695.1  nuclear factor 1 X-type isoform X13

      UniProtKB/Swiss-Prot
      O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
      UniProtKB/TrEMBL
      D3YZ00
      Conserved Domains (3) summary
      pfam10524
      Location:9 → 46
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:213 → 417
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:68 → 170
      MH1; N-terminal Mad Homology 1 (MH1) domain

    7. XM_036153809.1 → XP_036009702.1  nuclear factor 1 X-type isoform X19

      Conserved Domains (2) summary
      pfam00859
      Location:166 → 370
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    8. XM_036153807.1 → XP_036009700.1  nuclear factor 1 X-type isoform X18

      Conserved Domains (2) summary
      pfam00859
      Location:166 → 371
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    9. XM_036153808.1 → XP_036009701.1  nuclear factor 1 X-type isoform X18

      Conserved Domains (2) summary
      pfam00859
      Location:166 → 371
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    10. XM_036153803.1 → XP_036009696.1  nuclear factor 1 X-type isoform X14

      UniProtKB/Swiss-Prot
      O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
      UniProtKB/TrEMBL
      D3YZ00
      Conserved Domains (3) summary
      pfam10524
      Location:6 → 42
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:209 → 413
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:64 → 166
      MH1; N-terminal Mad Homology 1 (MH1) domain

    11. XM_036153798.1 → XP_036009691.1  nuclear factor 1 X-type isoform X9

      UniProtKB/TrEMBL
      D3YZ00
      Related
      ENSMUSP00000115691.2, ENSMUST00000126806.2
      Conserved Domains (3) summary
      pfam10524
      Location:9 → 46
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:213 → 501
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:68 → 170
      MH1; N-terminal Mad Homology 1 (MH1) domain

    12. XM_030243342.2 → XP_030099202.1  nuclear factor 1 X-type isoform X1

      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (2) summary
      pfam00859
      Location:166 → 455
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    13. XM_006530755.5 → XP_006530818.2  nuclear factor 1 X-type isoform X1

      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (2) summary
      pfam00859
      Location:166 → 455
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    14. XM_011248326.4 → XP_011246628.2  nuclear factor 1 X-type isoform X8

      Conserved Domains (2) summary
      pfam00859
      Location:166 → 329
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    15. XM_006530758.5 → XP_006530821.2  nuclear factor 1 X-type isoform X4

      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (2) summary
      pfam00859
      Location:166 → 413
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    16. XM_006530756.5 → XP_006530819.2  nuclear factor 1 X-type isoform X2

      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (2) summary
      pfam00859
      Location:166 → 454
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    17. XM_006530760.5 → XP_006530823.2  nuclear factor 1 X-type isoform X7

      Conserved Domains (2) summary
      pfam00859
      Location:166 → 330
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    18. XM_006530757.5 → XP_006530820.2  nuclear factor 1 X-type isoform X3

      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (2) summary
      pfam00859
      Location:166 → 414
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    19. XM_030243347.2 → XP_030099207.1  nuclear factor 1 X-type isoform X1

      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (2) summary
      pfam00859
      Location:166 → 455
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    20. XM_030243345.2 → XP_030099205.1  nuclear factor 1 X-type isoform X1

      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (2) summary
      pfam00859
      Location:166 → 455
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    21. XM_036153801.1 → XP_036009694.1  nuclear factor 1 X-type isoform X2

      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (2) summary
      pfam00859
      Location:166 → 454
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    22. XM_030243343.2 → XP_030099203.1  nuclear factor 1 X-type isoform X1

      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (2) summary
      pfam00859
      Location:166 → 455
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:21 → 123
      MH1; N-terminal Mad Homology 1 (MH1) domain

    23. XM_036153800.1 → XP_036009693.1  nuclear factor 1 X-type isoform X12

      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (3) summary
      pfam10524
      Location:2 → 38
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:205 → 493
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:60 → 162
      MH1; N-terminal Mad Homology 1 (MH1) domain

    24. XM_030243341.2 → XP_030099201.1  nuclear factor 1 X-type isoform X11

      UniProtKB/TrEMBL
      Q5CZY4
      Conserved Domains (3) summary
      pfam00859
      Location:209 → 497
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:6 → 42
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:64 → 166
      MH1; N-terminal Mad Homology 1 (MH1) domain

    25. XM_036153806.1 → XP_036009699.1  nuclear factor 1 X-type isoform X17

      Conserved Domains (3) summary
      pfam10524
      Location:9 → 49
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:216 → 380
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:71 → 173
      MH1; N-terminal Mad Homology 1 (MH1) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70257.2 GenPept UniProtKB/Swiss-Prot:P70257

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