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    ergo-1 Piwi domain-containing protein;Piwi-like protein ergo-1 [ Caenorhabditis elegans ]

    Gene ID: 178602, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ergo-1
    Official Full Name
    Piwi domain-containing protein;Piwi-like protein ergo-1
    Primary source
    WormBase:WBGene00019971
    Locus tag
    CELE_R09A1.1
    See related
    AllianceGenome:WB:WBGene00019971
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DEAD/H-box RNA helicase binding activity and siRNA binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing and siRNA processing. Located in cytoplasm. Is expressed in several structures, including gonad; neurons; pharynx; seam cell; and vulva. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See ergo-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (1008803..1018352)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene VASP tetramerization domain-containing protein;VASP_tetra domain-containing protein;WH1 domain-containing protein Neighboring gene Drf_GBD domain-containing protein Neighboring gene BTB domain-containing protein;SAM domain-containing protein Neighboring gene UPF0496 protein Neighboring gene FMRF-Like Peptide

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. Fischer SE, et al. PLoS Genet, 2011 Nov. PMID 22102828, Free PMC Article
    2. The surveillance of pre-mRNA splicing is an early step in C. elegans RNAi of endogenous genes. Newman MA, et al. Genes Dev, 2018 May 1. PMID 29739806, Free PMC Article
    3. The Caenorhabditis elegans HEN1 ortholog, HENN-1, methylates and stabilizes select subclasses of germline small RNAs. Billi AC, et al. PLoS Genet, 2012. PMID 22548001, Free PMC Article
    4. Maternal and zygotic gene regulatory effects of endogenous RNAi pathways. Almeida MV, et al. PLoS Genet, 2019 Feb. PMID 30759082, Free PMC Article
    5. Distinct phases of siRNA synthesis in an endogenous RNAi pathway in C. elegans soma. Gent JI, et al. Mol Cell, 2010 Mar 12. PMID 20116306, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERGO-1 recruits a second RNA-dependent RNA polymerases (RRF-1 or EGO-1), which in turn transcribes 22G-RNAs that interact with worm-specific argonautes to direct gene silencing.
      Title: Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DEAD/H-box RNA helicase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables siRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Piwi domain-containing protein;Piwi-like protein ergo-1
    NP_001300164.1
    • Confirmed by transcript evidence
    NP_001300165.1
    • Confirmed by transcript evidence
    NP_001300166.1
    • Partially confirmed by transcript evidence
    NP_503362.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1008803..1018352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070961.10 → NP_503362.2  Piwi-like protein ergo-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503362.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61931
      Conserved Domains (2) summary
      smart00949
      Location:421 → 557
      PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille
      cd04657
      Location:588 → 1080
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...

    2. NM_001313235.3 → NP_001300164.1  Piwi domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AY23
      Conserved Domains (2) summary
      smart00949
      Location:14 → 150
      PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille
      cl00628
      Location:181 → 673
      Piwi-like; Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The ...

    3. NM_001313236.3 → NP_001300165.1  Piwi domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASS5
      Conserved Domains (1) summary
      cl00628
      Location:30 → 392
      Piwi-like; PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The central component ...

    4. NM_001313237.3 → NP_001300166.1  Piwi domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AV28
      Conserved Domains (1) summary
      cl00628
      Location:1 → 269
      Piwi-like; PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The central component ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61931.2

    Gene LinkOut

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