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    Mtnr1a melatonin receptor 1A [ Mus musculus (house mouse) ]

    Gene ID: 17773, updated on 11-Nov-2024

    Summary

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    Official Symbol
    Mtnr1aprovided by MGI
    Official Full Name
    melatonin receptor 1Aprovided by MGI
    Primary source
    MGI:MGI:102967
    See related
    Ensembl:ENSMUSG00000054764 AllianceGenome:MGI:102967
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MR; MelR
    Summary
    Predicted to enable hormone binding activity; melatonin receptor activity; and organic cyclic compound binding activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and negative regulation of insulin secretion. Predicted to act upstream of or within circadian rhythm. Predicted to be located in neuronal cell body. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; liver and biliary system; and reproductive system. Orthologous to human MTNR1A (melatonin receptor 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 1.3), liver adult (RPKM 0.1) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtnr1a in Genome Data Viewer
    Location:
    8 B1.1; 8 24.95 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (45522144..45542270)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (45069107..45089233)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21352 Neighboring gene STARR-seq mESC enhancer starr_21353 Neighboring gene predicted gene 9908 Neighboring gene STARR-seq mESC enhancer starr_21356 Neighboring gene STARR-seq mESC enhancer starr_21359 Neighboring gene FAT atypical cadherin 1 Neighboring gene STARR-seq mESC enhancer starr_21360 Neighboring gene STARR-seq mESC enhancer starr_21361 Neighboring gene STARR-seq mESC enhancer starr_21364 Neighboring gene cDNA sequence AY512931 Neighboring gene STARR-seq mESC enhancer starr_21366 Neighboring gene predicted gene, 30504 Neighboring gene STARR-seq mESC enhancer starr_21368 Neighboring gene predicted gene 6329 Neighboring gene STARR-seq mESC enhancer starr_21369 Neighboring gene coagulation factor XI

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockdown of melatonin receptor 1 and induction of follicle-stimulating hormone on the regulation of mouse granulosa cell function. Talpur HS, et al. Reprod Biol, 2017 Dec. PMID 29097083
    2. Melatonin receptor activation suppresses adrenocorticotropin production via BMP-4 action by pituitary AtT20 cells. Tsukamoto N, et al. Mol Cell Endocrinol, 2013 Aug 15. PMID 23701823
    3. Genetic deletion of MT1 melatonin receptors alters spontaneous behavioral rhythms in male and female C57BL/6 mice. Adamah-Biassi EB, et al. Horm Behav, 2014 Sep. PMID 25200199, Free PMC Article
    4. Melancholic-Like behaviors and circadian neurobiological abnormalities in melatonin MT1 receptor knockout mice. Comai S, et al. Int J Neuropsychopharmacol, 2015 Jan 31. PMID 25638817, Free PMC Article
    5. Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling. Gianesini C, et al. Invest Ophthalmol Vis Sci, 2016 Jan 1. PMID 26780313, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Melatonin receptor 1A variants as genetic cause of idiopathic osteoporosis.
      Title: Melatonin receptor 1A variants as genetic cause of idiopathic osteoporosis.
    2. The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
      Title: The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
    3. Changes in melatonin receptor expression in a murine model of glaucoma.
      Title: Changes in melatonin receptor expression in a murine model of glaucoma.
    4. found in The organ of Corti, spiral ganglion, vestibular ganglion, vestibular sensory cells, vestibular dark and transitional cells, and endolymphatic sac epithelial cells
      Title: Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear.
    5. MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations.
      Title: MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations.
    6. study presents the first direct evidence that the MT2 subtype, but not MT1, is a novel endogenous cardiac protective receptor against MI/R injury. Medications specifically targeting MT2 may hold promise in fighting ischemic heart disease.
      Title: Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin-conferred cardioprotection against myocardial ischemia/reperfusion injury.
    7. MT1/MT2 receptors activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway.
      Title: Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway.
    8. These results suggested that the melatonin receptors MTNR1A and MTNR1B are essential to repress hCG-induced endoplasmic reticulum stress and cell apoptosis.
      Title: Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells.
    9. Melatonin MT1 and MT2 receptors interact with dopamine transporter (DAT) in striatum.
      Title: Melatonin receptors limit dopamine reuptake by regulating dopamine transporter cell-surface exposure.
    10. our data demonstrate that the activation of MT1 signaling at night modulates insulin sensitivity during the day via the regulation of the PI3K transcription and activity
      Title: Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC151277

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hormone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables melatonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables melatonin receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables organic cyclic compound binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables organic cyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within circadian rhythm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    melatonin receptor type 1A
    Names
    Mel1a receptor
    mel-1A-R

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008639.3 → NP_032665.1  melatonin receptor type 1A

      See identical proteins and their annotated locations for NP_032665.1

      Status: VALIDATED

      Source sequence(s)
      AC158352
      Consensus CDS
      CCDS22273.1
      UniProtKB/Swiss-Prot
      Q61184
      UniProtKB/TrEMBL
      Q14AC3
      Related
      ENSMUSP00000069872.8, ENSMUST00000067984.9
      Conserved Domains (2) summary
      pfam00001
      Location:47 → 298
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:38 → 160
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      45522144..45542270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509292.2 → XP_006509355.2  melatonin receptor type 1A isoform X1

      Conserved Domains (2) summary
      cd14964
      Location:31 → 56
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:27 → 275
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_017312597.1 → XP_017168086.1  melatonin receptor type 1A isoform X2

      Conserved Domains (2) summary
      cd14964
      Location:30 → 55
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:26 → 274
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_011242176.1 → XP_011240478.1  melatonin receptor type 1A isoform X4

      Conserved Domains (2) summary
      cd14964
      Location:3 → 28
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:3 → 247
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_006509291.3 → XP_006509354.1  melatonin receptor type 1A isoform X3

      Conserved Domains (2) summary
      cd14964
      Location:3 → 28
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:3 → 247
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61184.1 GenPept UniProtKB/Swiss-Prot:Q61184

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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