Mos Moloney sarcoma oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mosprovided by MGI
Official Full Name: Moloney sarcoma oncogeneprovided by MGI
Primary source: MGI:MGI:97052
See related: Ensembl:ENSMUSG00000078365 AllianceGenome:MGI:97052
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: c-mos
Summary: Predicted to enable MAP kinase kinase kinase activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of metaphase/anaphase transition of meiotic cell cycle; and positive regulation of MAPK cascade. Acts upstream of or within regulation of meiotic nuclear division. Located in cytoplasm. Is expressed in brain; early conceptus; gonad; large intestine; and metanephros. Orthologous to human MOS (MOS proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 4 A1; 4 2.16 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (3870658..3872105, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (3870658..3872105, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single Molecule RNA Localization and Translation in the Mammalian Oocyte and Embryo.
Title: Single Molecule RNA Localization and Translation in the Mammalian Oocyte and Embryo.
Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition
Title: Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.
This suggests that c-mos might play important roles in spermatogenesis
Title: Spatial and temporal expression of c-mos in mouse testis during postnatal development.
Mos protein is unstable in early mouse embryos
Title: Mos and the mitogen-activated protein kinase do not show cytostatic factor activity in early mouse embryos.
In Xenopus oocytes, the N-terminal Pro of murine & Xenopus c-MOS is dispensable for degradation if Ser-2 of c-MOS is replaced by a small non-phosphorylatable residue. The N-terminal Pro residue is not a recognition determinant for a ubiquitin ligase.
Title: Dissection of c-MOS degron.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mos (e-PCR), detects polymorphism
- UniSTS:143900

NoName (e-PCR)
- UniSTS:492607

Mos (e-PCR), detects polymorphism
- UniSTS:527426

Mos (e-PCR), detects polymorphism
- UniSTS:498243

NoName (e-PCR)
- UniSTS:234860

Mos (e-PCR), detects polymorphism
- UniSTS:256953

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in establishment of meiotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in oocyte maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of meiotic nuclear division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proto-oncogene serine/threonine-protein kinase mos

Names: c-mos proto-oncogene; oocyte maturation factor mos; proto-oncogene c-Mos

NP_064405.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.