Mnt max binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mntprovided by MGI
Official Full Name: max binding proteinprovided by MGI
Primary source: MGI:MGI:109150
See related: Ensembl:ENSMUSG00000000282 AllianceGenome:MGI:109150
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rox; bHLHd3
Summary: Enables DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Acts upstream of or within several processes, including cellular senescence; negative regulation of apoptotic signaling pathway; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; future brain; genitourinary system; and retina nuclear layer. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human MNT (MAX network transcriptional repressor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 15.8), adrenal adult (RPKM 10.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.76 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (74721651..74736551)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (74830806..74845725)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis.
Title: MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis.
Although mnt heterozygosity clearly slowed lymphomagenesis in vavP-MYC10 and Emu-myc mice, the change(s) in cellular properties responsible for this effect remain to be identified.
Title: Mnt modulates Myc-driven lymphomagenesis.
results redefine the physiological relationship between Mnt and Myc and requirements for Myc-driven oncogenesis
Title: A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis.
Mxd4 and Mnt upregulation following OX40 engagement most likely increases T-cell survival
Title: OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival.
The switch from Mnt-Max to Myc-Max during bile duct ligation (cholestasis) and in hepatocytes treated with lithocholic acid is responsible for the induction in p53 and cyclin D1 expression and contributes to apoptosis.
Title: Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes.
Mnt represses Myc target genes and Myc functions as an oncogene by relieving Mnt-mediated repression
Title: Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation.
There is a unique negative regulatory role for Mnt in governing key Myc functions associated with cell proliferation and tumorigenesis.
Title: Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis.
Loss of protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects.
Title: Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome.
Mnt may serve a general role as a Myc antagonist.[Review]
Title: Evidence of mnt-myc antagonism revealed by mnt gene deletion.
These results demonstrate that Mnt-Myc antagonism plays a fundamental role in regulating cell cycle entry and proliferation.
Title: Mnt-Max to Myc-Max complex switching regulates cell cycle entry.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G54861 (e-PCR)
- UniSTS:163630

Mnt (e-PCR), detects polymorphism
- UniSTS:546868

UniSTS:236639 (e-PCR)
- UniSTS:236639

PMC148819P8 (e-PCR)
- UniSTS:271021

PMC310661P2 (e-PCR)
- UniSTS:272624

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: max-binding protein MNT

Names: myc antagonist MNT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010813.3 → NP_034943.3 max-binding protein MNT

See identical proteins and their annotated locations for NP_034943.3

Status: VALIDATED

Source sequence(s)

AW491765, BC054534, CA327080

Consensus CDS

CCDS25037.1

UniProtKB/Swiss-Prot

O08789, P97349, Q6GTJ3

UniProtKB/TrEMBL

Q3UGG9

Related

ENSMUSP00000000291.3, ENSMUST00000000291.9

Conserved Domains (1) summary

cd11402
Location:222 → 298

bHLHzip_Mnt; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

74721651..74736551

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532402.5 → XP_006532465.1 max-binding protein MNT isoform X1

UniProtKB/TrEMBL

Q3UGG9

Conserved Domains (2) summary

pfam10944
Location:267 → 325

DUF2630; Protein of unknown function (DUF2630)

cd11402
Location:221 → 284

bHLHzip_Mnt; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins
XM_006532403.4 → XP_006532466.1 max-binding protein MNT isoform X2
XM_036156377.1 → XP_036012270.1 max-binding protein MNT isoform X2