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    lrp-1 Low-density lipoprotein receptor-related protein [ Caenorhabditis elegans ]

    Gene ID: 172520, updated on 2-Nov-2024

    Summary

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    Official Symbol
    lrp-1
    Official Full Name
    Low-density lipoprotein receptor-related protein
    Primary source
    WormBase:WBGene00003071
    Locus tag
    CELE_F29D11.1
    See related
    AllianceGenome:WB:WBGene00003071
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Involved in several processes, including ecdysis, collagen and cuticulin-based cuticle; nematode larval development; and sterol transport. Located in apical plasma membrane and endocytic vesicle. Is expressed in head and hypodermis. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See lrp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    27
    Sequence:
    Chromosome: I; NC_003279.8 (7614176..7634143)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene C2 domain-containing protein aex-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Condensin complex subunit capg-1 Neighboring gene ncRNA Neighboring gene Lipid droplet-associated hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting. Yochem J, et al. Development, 1999 Feb. PMID 9876188
    2. Low density lipoprotein receptors LRP-1 and LRP-2 in C. elegans. Minor P, et al. MicroPubl Biol, 2019 Aug 27. PMID 32550404, Free PMC Article
    3. Regulation of neuronal APL-1 expression by cholesterol starvation. Wiese M, et al. PLoS One, 2012. PMID 22363792, Free PMC Article
    4. C. elegans peb-1 mutants exhibit pleiotropic defects in molting, feeding, and morphology. Fernandez AP, et al. Dev Biol, 2004 Dec 15. PMID 15581870
    5. Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane. Roggo L, et al. EMBO J, 2002 Apr 2. PMID 11927551, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EPN-1/epsin as an essential factor in promoting internalization of the C. elegans LDLR superfamily member LRP-1.
      Title: Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ecdysis, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sterol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Low-density lipoprotein receptor-related protein
    NP_001379135.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7614176..7634143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392587.1 → NP_001379135.1  Low-density lipoprotein receptor-related protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q04833
      Conserved Domains (10) summary
      smart00192
      Location:1057 → 1087
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:2613 → 2655
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:4132 → 4163
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:3140 → 3174
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:4219 → 4257
      NHL; NHL repeat [structural motif]
      cl18310
      Location:4219 → 4431
      NHL; NHL repeat unit of beta-propeller proteins
      pfam00058
      Location:3445 → 3490
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:3586 → 3623
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      NF033759
      Location:1054 → 1451
      exchanger_TraA; outer membrane exchange protein TraA
      cl39070
      Location:1943 → 1986
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04833.1

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