Tpsb2 tryptase beta 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tpsb2provided by MGI
Official Full Name: tryptase beta 2provided by MGI
Primary source: MGI:MGI:96942
See related: Ensembl:ENSMUSG00000033825 AllianceGenome:MGI:96942
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mcp6; Mcp-6; Mcpt6; MMCP-6
Summary: Enables heparin binding activity and peptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within inflammatory response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; immune system; lumbar vertebra; and skin. Orthologous to several human genes including TPSAB1 (tryptase alpha/beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in mammary gland adult (RPKM 46.5), stomach adult (RPKM 13.0) and 6 other tissues See more
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Genomic context

Location:: 17 A3.3; 17 12.53 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (25585282..25587070)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (25366308..25368096)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HepaticIschemia/Reperfusion Injuryinvolves functional tryptase/PAR-2 signaling in liver sinusoidal endothelial cell population.
Title: HepaticIschemia/Reperfusion Injuryinvolves functional tryptase/PAR-2 signaling in liver sinusoidal endothelial cell population.
Protective role of mouse mast cell tryptase Mcpt6 in melanoma.
Title: Protective role of mouse mast cell tryptase Mcpt6 in melanoma.
High MCP6 expression is associated with small bowel cancer.
Title: Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner.
These data indicate that endogenous mMCP6 has scar-suppressing properties after spinal cord injury via indirect cleavage of axon growth-inhibitory scar components and alteration of the gene expression profile of these factors.
Title: Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6.
Inflammatory Th2 responses can develop independently of MCP-6, whereas MCP-6 plays a key role in the development of airway hyperresponsiveness.
Title: Mouse mast cell protease-6 and MHC are involved in the development of experimental asthma.
Tryptase-beta was capable of inducing pelvic pain and was increased in experimental autoimmune prostatitis.
Title: Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome.
Results suggest that mouse mast cell proteases 4, 5, and 6 are mediators of the critical role mast cells play in microdeformational wound therapy in the proliferative phase of healing.
Title: The role of mouse mast cell proteases in the proliferative phase of wound healing in microdeformational wound therapy.
Accumulated data in this review suggest that mast cells, their tryptases, and their chymases play important roles in tissue repair.
Title: Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.
mast cell tryptase, a serglycin proteoglycan-dependent secretory granule protease, has a role in proteolytic histone modification
Title: Proteolytic histone modification by mast cell tryptase, a serglycin proteoglycan-dependent secretory granule protease.
Trypase can promote atherosclerotic plaque haemorrhage by promoting angiogenesis and regulating the balance of PAI-1 and tPA.
Title: Tryptase promotes atherosclerotic plaque haemorrhage in ApoE-/- mice.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225057

Tpsb2 (e-PCR), detects polymorphism
- UniSTS:536698

Tpsb2 (e-PCR), detects polymorphism
- UniSTS:536699

Tpsb2 (e-PCR), detects polymorphism
- UniSTS:536700

AV011504 (e-PCR)
- UniSTS:166037

PMC316772P2 (e-PCR)
- UniSTS:273046

D17Mit46 (e-PCR), detects polymorphism
- UniSTS:116638

NoName (e-PCR)
- UniSTS:224733

Mcpt6 (e-PCR), detects polymorphism
- UniSTS:265725

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tryptase beta-2

Names: mast cell protease 6; tryptase-2

NP_034911.3

EC 3.4.21.59

XP_006523803.1

EC 3.4.21.59

XP_030105385.1

EC 3.4.21.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010781.3 → NP_034911.3 tryptase beta-2 precursor

See identical proteins and their annotated locations for NP_034911.3

Status: VALIDATED

Source sequence(s)

AC122454

Consensus CDS

CCDS28517.1

UniProtKB/Swiss-Prot

P21845, Q61962

UniProtKB/TrEMBL

B5A5B2, E9QJW9

Related

ENSMUSP00000157286.2, ENSMUST00000234477.3

Conserved Domains (1) summary

cd00190
Location:32 → 270

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

25585282..25587070

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523740.3 → XP_006523803.1 tryptase beta-2 isoform X1

See identical proteins and their annotated locations for XP_006523803.1

UniProtKB/Swiss-Prot

P21845, Q61962

UniProtKB/TrEMBL

B5A5B2, E9QJW9

Related

ENSMUSP00000159899.1, ENSMUST00000249732.1

Conserved Domains (1) summary

cd00190
Location:32 → 270

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_030249525.1 → XP_030105385.1 tryptase beta-2 isoform X2

Conserved Domains (1) summary

cd00190
Location:15 → 202

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...