Mark3 MAP/microtubule affinity regulating kinase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mark3provided by MGI
Official Full Name: MAP/microtubule affinity regulating kinase 3provided by MGI
Primary source: MGI:MGI:1341865
See related: Ensembl:ENSMUSG00000007411 AllianceGenome:MGI:1341865
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ETK1; Emk2; ETK-1; MPK10; C-TAK1; 1600015G02Rik; A430080F22Rik
Summary: Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; negative regulation of protein localization to nucleus; and peptidyl-serine autophosphorylation. Predicted to be located in dendrite. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; liver; and retina. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 28.6), CNS E14 (RPKM 28.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 61.05 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (111540929..111622661)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (111574505..111656227)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts.
Title: Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts.
Knockout mice were protected against high-fat diet-induced obesity and displayed attenuated weight gain, complete resistance to hepatic steatosis, and improved glucose handling with decreased insulin secretion.
Title: Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.
Approximately 50 additional residues preceding the previously defined KA1 domain are required for MARK3 proper folding.
Title: Solution structure of the kinase-associated domain 1 of mouse microtubule-associated protein/microtubule affinity-regulating kinase 3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (3)
Spontaneous (1) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mark3 (e-PCR), detects polymorphism
- UniSTS:527419

NoName (e-PCR)
- UniSTS:236952

NoName (e-PCR)
- UniSTS:236957

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables tau-protein kinase activity	ISO Inferred from Sequence Orthology more info
enables tau-protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-serine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: MAP/microtubule affinity-regulating kinase 3

Names: ELKL motif kinase 2; EMK-2; EMK2/MARK3 serine-threonine protein kinase; MPK-10

NP_001357673.1

EC 2.7.11.1

NP_001357674.1

EC 2.7.11.1

NP_067491.2

EC 2.7.11.1

NP_073712.2

EC 2.7.11.1

XP_006515574.1

EC 2.7.11.1

XP_006515575.1

EC 2.7.11.1

XP_006515576.1

EC 2.7.11.1

XP_006515577.1

EC 2.7.11.1

XP_006515580.1

EC 2.7.11.1

XP_006515581.1

EC 2.7.11.1

XP_006515582.1

EC 2.7.11.1

XP_011242308.1

EC 2.7.11.1

XP_011242309.1

EC 2.7.11.1

XP_030102427.1

EC 2.7.11.1

XP_030102428.1

EC 2.7.11.1

XP_036013096.1

EC 2.7.11.1

XP_036013097.1

EC 2.7.11.1

XP_036013098.1

EC 2.7.11.1

XP_036013099.1

EC 2.7.11.1

XP_036013100.1

EC 2.7.11.1

XP_036013101.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370744.1 → NP_001357673.1 MAP/microtubule affinity-regulating kinase 3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AC160972, AC163357

Consensus CDS

CCDS88407.1

UniProtKB/Swiss-Prot

Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4

UniProtKB/TrEMBL

Q9JKE5

Related

ENSMUSP00000152483.2, ENSMUST00000221459.2

Conserved Domains (3) summary

cd12196
Location:654 → 751

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:325 → 367

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:55 → 307

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
NM_001370745.1 → NP_001357674.1 MAP/microtubule affinity-regulating kinase 3 isoform 4

Status: VALIDATED

Source sequence(s)

AC160972, AC163357

Conserved Domains (3) summary

cd12196
Location:496 → 593

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:176 → 218

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cl21453
Location:1 → 158

PKc_like; Protein Kinases, catalytic domain
NM_021516.4 → NP_067491.2 MAP/microtubule affinity-regulating kinase 3 isoform 1

See identical proteins and their annotated locations for NP_067491.2

Status: VALIDATED

Source sequence(s)

AK083683, AK132247, AV275316

Consensus CDS

CCDS26181.1

UniProtKB/TrEMBL

Q9JKE5

Related

ENSMUSP00000082017.6, ENSMUST00000084953.13

Conserved Domains (4) summary

cd12196
Location:645 → 742

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

smart00220
Location:56 → 307

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14407
Location:325 → 367

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:55 → 307

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
NM_022801.4 → NP_073712.2 MAP/microtubule affinity-regulating kinase 3 isoform 2

See identical proteins and their annotated locations for NP_073712.2

Status: VALIDATED

Source sequence(s)

AC160972, AI850379, AK083683, BC066071, CA575239, CX566304

Consensus CDS

CCDS26182.1

UniProtKB/TrEMBL

Q9JKE5

Related

ENSMUSP00000074757.7, ENSMUST00000075281.8

Conserved Domains (4) summary

cd12196
Location:630 → 727

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

smart00220
Location:56 → 307

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14407
Location:325 → 367

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:55 → 307

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

111540929..111622661

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246567.2 → XP_030102427.1 MAP/microtubule affinity-regulating kinase 3 isoform X7

UniProtKB/TrEMBL

Q9JKE5

Conserved Domains (3) summary

cd12196
Location:629 → 726

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:325 → 367

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:55 → 307

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006515517.5 → XP_006515580.1 MAP/microtubule affinity-regulating kinase 3 isoform X6

UniProtKB/TrEMBL

Q9JKE5

Conserved Domains (3) summary

cd12196
Location:638 → 735

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:325 → 367

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:55 → 307

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_030246568.2 → XP_030102428.1 MAP/microtubule affinity-regulating kinase 3 isoform X12

Conserved Domains (3) summary

cd12196
Location:505 → 602

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:176 → 218

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cl21453
Location:1 → 158

PKc_like; Protein Kinases, catalytic domain
XM_036157205.1 → XP_036013098.1 MAP/microtubule affinity-regulating kinase 3 isoform X10

UniProtKB/TrEMBL

Q9JKE5

Conserved Domains (3) summary

cd12196
Location:565 → 662

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:261 → 303

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:18 → 243

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006515518.5 → XP_006515581.1 MAP/microtubule affinity-regulating kinase 3 isoform X8

UniProtKB/TrEMBL

Q9JKE5

Conserved Domains (3) summary

cd12196
Location:614 → 711

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:325 → 367

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:55 → 307

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_036157204.1 → XP_036013097.1 MAP/microtubule affinity-regulating kinase 3 isoform X9

UniProtKB/TrEMBL

Q9JKE5

Conserved Domains (3) summary

cd12196
Location:590 → 687

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:261 → 303

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:18 → 243

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_036157207.1 → XP_036013100.1 MAP/microtubule affinity-regulating kinase 3 isoform X13

Conserved Domains (3) summary

cd12196
Location:489 → 586

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:176 → 218

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cl21453
Location:1 → 158

PKc_like; Protein Kinases, catalytic domain
XM_011244006.3 → XP_011242308.1 MAP/microtubule affinity-regulating kinase 3 isoform X14

Conserved Domains (1) summary

cd12196
Location:359 → 456

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
XM_006515511.5 → XP_006515574.1 MAP/microtubule affinity-regulating kinase 3 isoform X1

UniProtKB/TrEMBL

Q9JKE5

Conserved Domains (3) summary

cd12196
Location:707 → 804

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:325 → 367

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:55 → 307

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006515512.5 → XP_006515575.1 MAP/microtubule affinity-regulating kinase 3 isoform X2

UniProtKB/TrEMBL

A0A1Y7VNZ6, Q9JKE5

Related

ENSMUSP00000152727.2, ENSMUST00000221753.2

Conserved Domains (3) summary

cd12196
Location:698 → 795

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:325 → 367

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:55 → 307

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_006515514.5 → XP_006515577.1 MAP/microtubule affinity-regulating kinase 3 isoform X4

UniProtKB/TrEMBL

Q9JKE5

Conserved Domains (3) summary

cd12196
Location:683 → 780

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:325 → 367

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:55 → 307

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_011244007.3 → XP_011242309.1 MAP/microtubule affinity-regulating kinase 3 isoform X15

Conserved Domains (1) summary

cd12196
Location:343 → 440

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
XM_006515513.5 → XP_006515576.1 MAP/microtubule affinity-regulating kinase 3 isoform X3

UniProtKB/TrEMBL

Q9JKE5

Conserved Domains (3) summary

cd12196
Location:691 → 788

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:325 → 367

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:55 → 307

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_036157208.1 → XP_036013101.1 MAP/microtubule affinity-regulating kinase 3 isoform X14

Conserved Domains (1) summary

cd12196
Location:359 → 456

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
XM_006515519.3 → XP_006515582.1 MAP/microtubule affinity-regulating kinase 3 isoform X11

Conserved Domains (3) summary

cd12196
Location:558 → 655

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:176 → 218

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cl21453
Location:1 → 158

PKc_like; Protein Kinases, catalytic domain
XM_036157203.1 → XP_036013096.1 MAP/microtubule affinity-regulating kinase 3 isoform X5

UniProtKB/TrEMBL

Q9JKE5

Conserved Domains (3) summary

cd12196
Location:643 → 740

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:261 → 303

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cd14072
Location:18 → 243

STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
XM_036157206.1 → XP_036013099.1 MAP/microtubule affinity-regulating kinase 3 isoform X11

Conserved Domains (3) summary

cd12196
Location:558 → 655

MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3

cd14407
Location:176 → 218

UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins

cl21453
Location:1 → 158

PKc_like; Protein Kinases, catalytic domain