Grip2 glutamate receptor interacting protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grip2provided by RGD
Official Full Name: glutamate receptor interacting protein 2provided by RGD
Primary source: RGD:621668
See related: EnsemblRapid:ENSRNOG00000009726 AllianceGenome:RGD:621668
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Abp
Summary: Enables glutamate receptor binding activity. Involved in positive regulation of AMPA glutamate receptor clustering; positive regulation of excitatory postsynaptic potential; and positive regulation of neuron maturation. Located in several cellular components, including dendritic shaft; neuronal cell body; and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human GRIP2 (glutamate receptor interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 19.6), Heart (RPKM 14.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (125828609..125913693, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (124271456..124356538, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (123585184..123636040)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions.
Title: GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions.
postsynaptic palmitoylated ABP induces pre and postsynaptic changes that are dependent on palmitoylation and likely achieved through ABP association with a multi-molecular cell surface signaling complex.
Title: Regulation of synaptic structure and function by palmitoylated AMPA receptor binding protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glutamate receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within artery smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of AMPA glutamate receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport in synapse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuron spine	IDA Inferred from Direct Assay more info	PubMed
located_in neuron spine	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate receptor-interacting protein 2

Names: AMPA receptor binding protein; AMPA receptor-interacting protein GRIP2; GRIP-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138535.2 → NP_612544.2 glutamate receptor-interacting protein 2

See identical proteins and their annotated locations for NP_612544.2

Status: VALIDATED

Source sequence(s)

AF205193, JAXUCZ010000004

UniProtKB/Swiss-Prot

O88961, Q9WTW1, Q9WU36

UniProtKB/TrEMBL

A0A8I5ZW05

Related

ENSRNOP00000041016.3, ENSRNOT00000049657.7

Conserved Domains (1) summary

cd00992
Location:657 → 737

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

125828609..125913693 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039106989.2 → XP_038962917.1 glutamate receptor-interacting protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZW05

Related

ENSRNOP00000101025.1, ENSRNOT00000144463.1

Conserved Domains (1) summary

cd00992
Location:657 → 737

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006236895.5 → XP_006236957.1 glutamate receptor-interacting protein 2 isoform X3

UniProtKB/TrEMBL

A0A0H2UHH8

Related

ENSRNOP00000013232.6, ENSRNOT00000013232.8

Conserved Domains (1) summary

cd00992
Location:616 → 696

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_017592425.3 → XP_017447914.1 glutamate receptor-interacting protein 2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZW05

Related

ENSRNOP00000105286.1, ENSRNOT00000159958.1
XM_008763122.4 → XP_008761344.2 glutamate receptor-interacting protein 2 isoform X4

UniProtKB/TrEMBL

A6IBA9

Related

ENSRNOP00000110627.1, ENSRNOT00000137049.1