Elovl6 ELOVL fatty acid elongase 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Elovl6provided by RGD
Full Name: ELOVL fatty acid elongase 6provided by RGD
Primary source: RGD:620585
See related: EnsemblRapid:ENSRNOG00000048949 AllianceGenome:RGD:620585
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lce2; rELO2
Summary: Enables fatty acid elongase activity. Involved in fatty acid elongation, monounsaturated fatty acid and fatty acid elongation, saturated fatty acid. Predicted to be located in endoplasmic reticulum. Predicted to be part of fatty acid elongase complex. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human ELOVL6 (ELOVL fatty acid elongase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 148.6), Liver (RPKM 129.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (220738095..220845528)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (218063682..218174767)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (234187490..234296124, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dysregulation of Elovl6-driven long-chain fatty acid metabolism induces phenotypic switching of VSMC via ROS production and AMPK/KLF4 signaling that leads to growth arrest and downregulation of VSMC marker expression.
Title: Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Krüppel-Like Factor 4 (AMPK/KLF4) Signaling.
Results show that delta-6 desaturase as well as elongase-6 expressions were upregulated in 3-month-old Zucker fatty rats as compared to lean littermates.
Title: The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats.
Overt type 2 diabetes is associated with diminished islet expression of SCD and Elovl6, and this can disrupt desaturation of saturated FAs to MUFAs, rendering beta-cells more susceptible to saturated FA-induced ER stress and apoptosis.
Title: Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6.
increased expression genes encoding Scd1, Elovl6, and other key lipogenic enzymes may favor fat storage after chronic food restriction/refeeding and may be part of the molecular mechanism by which food restriction/refeeding increases body weight
Title: Up-regulation of stearoyl-CoA desaturase 1 and elongase 6 genes expression in rat lipogenic tissues by chronic food restriction and chronic food restriction/refeeding.
These findings demonstrate that coordinated induction of fatty acid elongases Elovl5 and 6 and desaturase activity is required for balanced synthesis of specific n-7 versus n-9 MUFA species.
Title: Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species.
Gene expressions of ELOVL6 and SPC24 were upregulated, and SERPINA7 was downregulated in the livers of rats with ventromedial hypothalamic lesions.
Title: Gene expression profiling in rat liver after VMH lesioning.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups	ISO Inferred from Sequence Orthology more info
enables fatty acid elongase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid elongase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acid elongase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid elongase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid elongation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid elongation, monounsaturated fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid elongation, monounsaturated fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid elongation, polyunsaturated fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid elongation, saturated fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid elongation, saturated fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid elongation, saturated fatty acid	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-chain fatty-acyl-CoA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in unsaturated fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in very long-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
part_of fatty acid elongase complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: very long chain fatty acid elongase 6

Names: 3-keto acyl-CoA synthase Elovl6; ELOVL FA elongase 6; ELOVL family member 6, elongation of long chain fatty acids; elongation of very long chain fatty acids protein 6; elongation of very long chain fatty acids protein 6-like; fatty acid elongase 2; fatty acyl-CoA elongase; long-chain fatty-acyl elongase; very long chain 3-ketoacyl-CoA synthase 6; very long chain 3-oxoacyl-CoA synthase 6

NP_599210.1

EC 2.3.1.199

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.