Inpp5j inositol polyphosphate-5-phosphatase J [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Inpp5jprovided by RGD
Official Full Name: inositol polyphosphate-5-phosphatase Jprovided by RGD
Primary source: RGD:620541
See related: EnsemblRapid:ENSRNOG00000019361 AllianceGenome:RGD:620541
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Inpp; Pipp; Pib5pa
Summary: Enables inositol-polyphosphate 5-phosphatase activity. Involved in negative regulation of microtubule polymerization and negative regulation of neuron projection development. Located in growth cone and ruffle membrane. Orthologous to human INPP5J (inositol polyphosphate-5-phosphatase J). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 50.0), Heart (RPKM 36.7) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (82597789..82608930, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (78374161..78385305, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (83730861..83742016, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PIPP and CRMP2 exert opposing roles in promoting axon selection and neurite elongation and the complex between these proteins serves to regulate the localization of effectors that promote neurite extension.
Title: Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)•collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation.
crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy
Title: Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy.
Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.
Title: Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables inositol phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol trisphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,4,5-trisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol-polyphosphate 5-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of microtubule polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in ruffle	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Names: phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase; phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase; proline-rich inositol polyphosphate 5-phosphatase

NP_598246.1

EC 3.1.3.36

EC 3.1.3.56

XP_006251217.1

EC 3.1.3.36

EC 3.1.3.56

XP_063128909.1

EC 3.1.3.36

EC 3.1.3.56

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133562.2 → NP_598246.1 phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

See identical proteins and their annotated locations for NP_598246.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q9JMC1

UniProtKB/TrEMBL

A6IKB6

Conserved Domains (1) summary

cd09094
Location:418 → 725

INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

82597789..82608930 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272839.1 → XP_063128909.1 phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X2
XM_006251155.5 → XP_006251217.1 phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X1

UniProtKB/TrEMBL

A0A8L2QEW5

Related

ENSRNOP00000026293.3, ENSRNOT00000026293.5

Conserved Domains (1) summary

cd09094
Location:411 → 718

INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins