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    Zfp384 zinc finger protein 384 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171018, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp384provided by RGD
    Official Full Name
    zinc finger protein 384provided by RGD
    Primary source
    RGD:708346
    See related
    EnsemblRapid:ENSRNOG00000017066 AllianceGenome:RGD:708346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ciz; Nmp4; Znf384
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SH3 domain binding activity. Involved in nucleocytoplasmic transport; positive regulation of protein secretion; and positive regulation of transcription by RNA polymerase II. Located in focal adhesion. Orthologous to human ZNF384 (zinc finger protein 384). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 120.8), Spleen (RPKM 96.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp384 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159496481..159526010)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157810263..157840052)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157523083..157552606)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102387 Neighboring gene COP9 signalosome subunit 7A Neighboring gene PILR alpha associated neural protein Neighboring gene uncharacterized LOC102554095 Neighboring gene inhibitor of growth family, member 4 Neighboring gene acrosin binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CIZ, a zinc finger protein that interacts with p130(cas) and activates the expression of matrix metalloproteinases. Nakamoto T, et al. Mol Cell Biol, 2000 Mar. PMID 10669742, Free PMC Article
    2. Nmp4/CIZ regulation of matrix metalloproteinase 13 (MMP-13) response to parathyroid hormone in osteoblasts. Shah R, et al. Am J Physiol Endocrinol Metab, 2004 Aug. PMID 15026307
    3. Osteoblast intracellular localization of Nmp4 proteins. Torrungruang K, et al. Bone, 2002 Jun. PMID 12052465
    4. Cloning and functional analysis of a family of nuclear matrix transcription factors (NP/NMP4) that regulate type I collagen expression in osteoblasts. Thunyakitpisal P, et al. J Bone Miner Res, 2001 Jan. PMID 11149472
    5. Ciz, a transcription factor with a nucleocytoplasmic shuttling activity, interacts with C-propeptides of type I collagen. Hayata T, et al. Biochem Biophys Res Commun, 2008 Apr 4. PMID 18211825

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results revealed that Ciz interacts with C-propeptides of type I collagen and this association takes place in nuclei.
      Title: Ciz, a transcription factor with a nucleocytoplasmic shuttling activity, interacts with C-propeptides of type I collagen.
    2. Nmp4/CIZ is a component of a multiprotein assemblage or enhanceosome within the MMP-13 parathyroid hormone response region and that, within this context, Nmp4/CIZ promotes both basal expression and hormonal synergy.
      Title: Nmp4/CIZ regulation of matrix metalloproteinase 13 (MMP-13) response to parathyroid hormone in osteoblasts.
    3. localization in the cytoplasm of osteoblasts[Nmp4 - nuclear matrix protein 4]
      Title: Osteoblast intracellular localization of Nmp4 proteins.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SH3 domain binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleocytoplasmic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 384
    Names
    Cas-associated zinc finger protein
    nuclear matrix protein 4
    nuclear matrix transcription factor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034830.2 → NP_001030002.1  zinc finger protein 384 isoform 1

      See identical proteins and their annotated locations for NP_001030002.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q9EQJ2, Q9EQJ3, Q9EQJ4, Q9JMJ5
      UniProtKB/TrEMBL
      A0A8J8XAE9, A6ILP2
      Conserved Domains (3) summary
      COG5048
      Location:209 → 409
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:320 → 340
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:243 → 268
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001034831.2 → NP_001030003.1  zinc finger protein 384 isoform 2

      See identical proteins and their annotated locations for NP_001030003.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2K403, A6ILP4
      Related
      ENSRNOP00000023242.6, ENSRNOT00000023240.10
      Conserved Domains (3) summary
      COG5048
      Location:209 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:243 → 268
      zf-H2C2_2; Zinc-finger double domain

    3. NM_133429.3 → NP_596920.2  zinc finger protein 384 isoform 1

      See identical proteins and their annotated locations for NP_596920.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q9EQJ2, Q9EQJ3, Q9EQJ4, Q9JMJ5
      UniProtKB/TrEMBL
      A0A8J8XAE9, A6ILP2
      Related
      ENSRNOP00000023192.7, ENSRNOT00000023192.9
      Conserved Domains (3) summary
      COG5048
      Location:209 → 409
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:320 → 340
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:243 → 268
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159496481..159526010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285447.1 → XP_063141517.1  zinc finger protein 384 isoform X3

      UniProtKB/TrEMBL
      A0A8J8XAE9, A6ILP2

    2. XM_017592416.3 → XP_017447905.1  zinc finger protein 384 isoform X1

      UniProtKB/Swiss-Prot
      Q9EQJ2, Q9EQJ3, Q9EQJ4, Q9JMJ5
      UniProtKB/TrEMBL
      D3ZWX3
      Conserved Domains (2) summary
      COG5048
      Location:285 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:351 → 371
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_017592413.3 → XP_017447902.1  zinc finger protein 384 isoform X1

      UniProtKB/Swiss-Prot
      Q9EQJ2, Q9EQJ3, Q9EQJ4, Q9JMJ5
      UniProtKB/TrEMBL
      D3ZWX3
      Conserved Domains (2) summary
      COG5048
      Location:285 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:351 → 371
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_063285450.1 → XP_063141520.1  zinc finger protein 384 isoform X5

      UniProtKB/TrEMBL
      D4A6Z1, G3V9M5

    5. XM_063285451.1 → XP_063141521.1  zinc finger protein 384 isoform X5

      UniProtKB/TrEMBL
      D4A6Z1, G3V9M5

    6. XM_063285454.1 → XP_063141524.1  zinc finger protein 384 isoform X7

      UniProtKB/TrEMBL
      A6ILP4

    7. XM_006237327.4 → XP_006237389.1  zinc finger protein 384 isoform X1

      UniProtKB/Swiss-Prot
      Q9EQJ2, Q9EQJ3, Q9EQJ4, Q9JMJ5
      UniProtKB/TrEMBL
      D3ZWX3
      Related
      ENSRNOP00000037592.5, ENSRNOT00000036654.9
      Conserved Domains (2) summary
      COG5048
      Location:285 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:351 → 371
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_063285453.1 → XP_063141523.1  zinc finger protein 384 isoform X7

      UniProtKB/TrEMBL
      A6ILP4

    9. XM_063285452.1 → XP_063141522.1  zinc finger protein 384 isoform X6

    10. XM_063285446.1 → XP_063141516.1  zinc finger protein 384 isoform X2

    11. XM_063285448.1 → XP_063141518.1  zinc finger protein 384 isoform X4

      UniProtKB/TrEMBL
      A6ILP5

    12. XM_063285455.1 → XP_063141525.1  zinc finger protein 384 isoform X8

      UniProtKB/TrEMBL
      G3V883

    13. XM_063285456.1 → XP_063141526.1  zinc finger protein 384 isoform X10

    14. XM_017592415.3 → XP_017447904.1  zinc finger protein 384 isoform X1

      UniProtKB/Swiss-Prot
      Q9EQJ2, Q9EQJ3, Q9EQJ4, Q9JMJ5
      UniProtKB/TrEMBL
      D3ZWX3
      Conserved Domains (2) summary
      COG5048
      Location:285 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:351 → 371
      ZF_C2H2; C2H2 Zn finger [structural motif]

    15. XM_017592417.3 → XP_017447906.1  zinc finger protein 384 isoform X1

      UniProtKB/Swiss-Prot
      Q9EQJ2, Q9EQJ3, Q9EQJ4, Q9JMJ5
      UniProtKB/TrEMBL
      D3ZWX3
      Conserved Domains (2) summary
      COG5048
      Location:285 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:351 → 371
      ZF_C2H2; C2H2 Zn finger [structural motif]

    16. XM_063285449.1 → XP_063141519.1  zinc finger protein 384 isoform X5

      UniProtKB/TrEMBL
      D4A6Z1, G3V9M5
      Related
      ENSRNOP00000052839.4, ENSRNOT00000055985.7

    17. XM_039106974.2 → XP_038962902.1  zinc finger protein 384 isoform X9

      Conserved Domains (2) summary
      COG5048
      Location:140 → 295
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:206 → 226
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQJ4.1 GenPept UniProtKB/Swiss-Prot:Q9EQJ4

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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