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    Ppp1r14c protein phosphatase 1, regulatory (inhibitor) subunit 14c [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171010, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Ppp1r14cprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory (inhibitor) subunit 14cprovided by RGD
    Primary source
    RGD:620538
    See related
    EnsemblRapid:ENSRNOG00000016368 AllianceGenome:RGD:620538
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kepi
    Summary
    Enables protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in negative regulation of catalytic activity and regulation of phosphorylation. Located in membrane. Orthologous to human PPP1R14C (protein phosphatase 1 regulatory inhibitor subunit 14C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 360.5), Lung (RPKM 102.2) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp1r14c in Genome Data Viewer
    Location:
    1p11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (42177977..42358654)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (39773403..39886970)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (39811314..39923071)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100095 Neighboring gene uncharacterized LOC102555832 Neighboring gene iodotyrosine deiodinase Neighboring gene pleckstrin homology and RhoGEF domain containing G1 Neighboring gene 60S ribosomal protein L7a pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. Liu QR, et al. J Biol Chem, 2002 Apr 12. PMID 11812771
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. regulation by morphine
      Title: KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93087

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 14C
    Names
    PKC-potentiated PP1 inhibitory protein
    kinase-enhanced PP1 inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133425.3 → NP_596916.1  protein phosphatase 1 regulatory subunit 14C

      See identical proteins and their annotated locations for NP_596916.1

      Status: PROVISIONAL

      Source sequence(s)
      AF407168
      UniProtKB/Swiss-Prot
      Q8R4R9
      UniProtKB/TrEMBL
      A6KIK0
      Related
      ENSRNOP00000022046.2, ENSRNOT00000022046.5
      Conserved Domains (1) summary
      pfam05361
      Location:70 → 164
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      42177977..42358654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273005.1 → XP_063129075.1  protein phosphatase 1 regulatory subunit 14C isoform X1

      Related
      ENSRNOP00000100870.1, ENSRNOT00000168146.1

    2. XM_039085420.2 → XP_038941348.1  protein phosphatase 1 regulatory subunit 14C isoform X2

      Conserved Domains (1) summary
      pfam05361
      Location:42 → 105
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    RNA

    1. XR_010057354.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4R9.1 GenPept UniProtKB/Swiss-Prot:Q8R4R9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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