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    XAGE5 X antigen family member 5 [ Homo sapiens (human) ]

    Gene ID: 170627, updated on 17-Sep-2024

    Summary

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    Official Symbol
    XAGE5provided by HGNC
    Official Full Name
    X antigen family member 5provided by HGNC
    Primary source
    HGNC:HGNC:30930
    See related
    Ensembl:ENSG00000171405 MIM:301063; AllianceGenome:HGNC:30930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT12.5; GAGED5; XAGE-5
    Summary
    This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See XAGE5 in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (52811287..52818301)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (52096193..52103207)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (52840311..52847325)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SSX family member 21, pseudogene Neighboring gene SPANX family member N5 Neighboring gene X antigen family member 3-like Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:52855217-52856182 Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. Zendman AJ, et al. Int J Cancer, 2002 May 20. PMID 11992404
    2. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119799, MGC119800

    General protein information

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    Preferred Names
    X antigen family member 5
    Names
    G antigen, family D, 5
    cancer/testis antigen 12.5
    cancer/testis antigen family 12, member 5
    g antigen family D member 5
    protein XAGE-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386970.1 → NP_001373899.1  X antigen family member 5

      Status: VALIDATED

      Source sequence(s)
      AC244505
      Consensus CDS
      CCDS14346.1
      UniProtKB/Swiss-Prot
      Q5JS81, Q8WWM1
      Related
      ENSP00000364651.1, ENST00000375501.2
      Conserved Domains (1) summary
      pfam05831
      Location:17 → 102
      GAGE; GAGE protein

    2. NM_130775.3 → NP_570131.1  X antigen family member 5

      See identical proteins and their annotated locations for NP_570131.1

      Status: VALIDATED

      Source sequence(s)
      AC244505
      Consensus CDS
      CCDS14346.1
      UniProtKB/Swiss-Prot
      Q5JS81, Q8WWM1
      Conserved Domains (1) summary
      pfam05831
      Location:17 → 102
      GAGE; GAGE protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      52811287..52818301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      52096193..52103207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WWM1.1 GenPept UniProtKB/Swiss-Prot:Q8WWM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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