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    Lrrfip1 leucine rich repeat (in FLII) interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 16978, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lrrfip1provided by MGI
    Official Full Name
    leucine rich repeat (in FLII) interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1342770
    See related
    Ensembl:ENSMUSG00000026305 AllianceGenome:MGI:1342770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fliiap1
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Acts upstream of or within positive regulation of NF-kappaB transcription factor activity. Predicted to be located in cytosol and plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Orthologous to human LRRFIP1 (LRR binding FLII interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 22.2), placenta adult (RPKM 10.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrfip1 in Genome Data Viewer
    Location:
    1 D; 1 46.03 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (90924652..91056666)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (90996930..91128944)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene prolactin releasing hormone Neighboring gene RAB17, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E4334 Neighboring gene STARR-positive B cell enhancer ABC_E3290 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:92961823-92961976 Neighboring gene predicted gene, 35443 Neighboring gene RNA binding motif protein 44 Neighboring gene proteasome (prosome, macropain) 28 subunit, alpha pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Leucine-rich repeat (in Flightless I) interacting protein-1 regulates a rapid type I interferon response. Bagashev A, et al. J Interferon Cytokine Res, 2010 Nov. PMID 20586614, Free PMC Article
    2. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Yang P, et al. Nat Immunol, 2010 Jun. PMID 20453844
    3. Higher LRRFIP1 expression in glioblastoma multiforme is associated with better response to teniposide, a type II topoisomerase inhibitor. Li WQ, et al. Biochem Biophys Res Commun, 2014 Apr 18. PMID 24690174
    4. Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. Liu YT, et al. J Biol Chem, 1998 Apr 3. PMID 9525888
    5. Functions of gelsolin: motility, signaling, apoptosis, cancer. Kwiatkowski DJ. Curr Opin Cell Biol, 1999 Feb. PMID 10047530

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Experiments in nude mice demonstrated better response of LRRFIP1 overexpressing glioblastoma multiforme xenografts to teniposide.
      Title: Higher LRRFIP1 expression in glioblastoma multiforme is associated with better response to teniposide, a type II topoisomerase inhibitor.
    2. regulates a rapid type I interferon response
      Title: Leucine-rich repeat (in Flightless I) interacting protein-1 regulates a rapid type I interferon response.
    3. LRRFIP1 and its downstream partner beta-catenin constitute another coactivator pathway for IRF3-mediated production of type I interferon
      Title: The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat flightless-interacting protein 1
    Names
    FLAP (FLI LRR associated protein)
    FLI-LRR-associated protein 1
    H186 FLAP
    LRR FLII-interacting protein 1
    flap-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111311.1 → NP_001104781.1  leucine-rich repeat flightless-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001104781.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AK077637, AK134120, AK162191, AV024479, BB709810
      Consensus CDS
      CCDS48320.1
      UniProtKB/Swiss-Prot
      O70323, Q3TS94, Q3UZ39
      Related
      ENSMUSP00000095254.4, ENSMUST00000097649.10
      Conserved Domains (1) summary
      pfam09738
      Location:42 → 258
      DUF2051; Double stranded RNA binding protein (DUF2051)

    2. NM_001111312.1 → NP_001104782.1  leucine-rich repeat flightless-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001104782.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region and contains different segments for both UTRs, compared to variant 1. The resulting protein (isoform 3) is shorter and has distinct N- and C-termini when it is compared to isoform 1.
      Source sequence(s)
      AF045573, AI452149, AK041162, BC145642, CJ154753
      Consensus CDS
      CCDS48319.1
      UniProtKB/TrEMBL
      G5E8E1, Q8BLV4
      Related
      ENSMUSP00000065850.7, ENSMUST00000068116.13
      Conserved Domains (1) summary
      pfam09738
      Location:52 → 352
      DUF2051; Double stranded RNA binding protein (DUF2051)

    3. NM_001310732.1 → NP_001297661.1  leucine-rich repeat flightless-interacting protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the 3' UTR and in the coding region, but maintains the reading frame compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus and lacks several internal segments compared to isoform 1.
      Source sequence(s)
      AC162883
      Consensus CDS
      CCDS78647.1
      UniProtKB/TrEMBL
      A0A087WPK3, A6H5U5
      Related
      ENSMUSP00000139811.2, ENSMUST00000189617.3
      Conserved Domains (2) summary
      COG1340
      Location:385 → 655
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cl12057
      Location:385 → 463
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    4. NM_008515.4 → NP_032541.1  leucine-rich repeat flightless-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_032541.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region and contains a different 3' UTR, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AF045573, AI452149, AK077637, BC145642, BY739242
      Consensus CDS
      CCDS35662.1
      UniProtKB/TrEMBL
      E9Q9T1
      Related
      ENSMUSP00000095255.4, ENSMUST00000097650.10
      Conserved Domains (1) summary
      COG1340
      Location:350 → 620
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      90924652..91056666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529209.4 → XP_006529272.1  leucine-rich repeat flightless-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A6H5U5
      Related
      ENSMUSP00000139497.2, ENSMUST00000185531.7
      Conserved Domains (3) summary
      TIGR04211
      Location:398 → 486
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:260 → 613
      LRRFIP; LRRFIP family
      pfam11932
      Location:629 → 688
      DUF3450; Protein of unknown function (DUF3450)

    2. XM_017318960.2 → XP_017174449.1  leucine-rich repeat flightless-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      A6H5U5
      Conserved Domains (2) summary
      pfam09738
      Location:260 → 582
      LRRFIP; LRRFIP family
      pfam11932
      Location:598 → 657
      DUF3450; Protein of unknown function (DUF3450)

    3. XM_017318958.2 → XP_017174447.1  leucine-rich repeat flightless-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A6H5U5
      Conserved Domains (3) summary
      TIGR04211
      Location:374 → 462
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:260 → 589
      LRRFIP; LRRFIP family
      pfam11932
      Location:605 → 664
      DUF3450; Protein of unknown function (DUF3450)

    4. XM_017318961.2 → XP_017174450.1  leucine-rich repeat flightless-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      A6H5U5
      Conserved Domains (2) summary
      pfam09738
      Location:245 → 574
      LRRFIP; LRRFIP family
      pfam11932
      Location:590 → 649
      DUF3450; Protein of unknown function (DUF3450)

    5. XM_017318969.2 → XP_017174458.1  leucine-rich repeat flightless-interacting protein 1 isoform X5

      UniProtKB/TrEMBL
      E9Q9T1
      Conserved Domains (2) summary
      pfam09738
      Location:223 → 552
      LRRFIP; LRRFIP family
      pfam11932
      Location:568 → 627
      DUF3450; Protein of unknown function (DUF3450)

    6. XM_017318974.2 → XP_017174463.1  leucine-rich repeat flightless-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      E9Q9T1
      Conserved Domains (2) summary
      pfam09738
      Location:197 → 526
      LRRFIP; LRRFIP family
      pfam11932
      Location:542 → 601
      DUF3450; Protein of unknown function (DUF3450)

    7. XM_017318999.2 → XP_017174488.1  leucine-rich repeat flightless-interacting protein 1 isoform X9

      UniProtKB/TrEMBL
      E9Q9T1
      Conserved Domains (2) summary
      pfam09738
      Location:197 → 495
      LRRFIP; LRRFIP family
      pfam11932
      Location:511 → 570
      DUF3450; Protein of unknown function (DUF3450)

    8. XM_017319017.2 → XP_017174506.1  leucine-rich repeat flightless-interacting protein 1 isoform X14

      Conserved Domains (2) summary
      pfam09738
      Location:197 → 464
      LRRFIP; LRRFIP family
      pfam11932
      Location:480 → 539
      DUF3450; Protein of unknown function (DUF3450)

    9. XM_036162412.1 → XP_036018305.1  leucine-rich repeat flightless-interacting protein 1 isoform X13

      Conserved Domains (2) summary
      pfam09738
      Location:175 → 466
      LRRFIP; LRRFIP family
      pfam11932
      Location:482 → 541
      DUF3450; Protein of unknown function (DUF3450)

    10. XM_017318996.2 → XP_017174485.1  leucine-rich repeat flightless-interacting protein 1 isoform X8

      UniProtKB/TrEMBL
      E9Q9T1
      Conserved Domains (2) summary
      pfam09738
      Location:175 → 504
      LRRFIP; LRRFIP family
      pfam11932
      Location:520 → 579
      DUF3450; Protein of unknown function (DUF3450)

    11. XM_017319004.2 → XP_017174493.1  leucine-rich repeat flightless-interacting protein 1 isoform X12

      UniProtKB/TrEMBL
      E9Q9T1
      Conserved Domains (2) summary
      pfam09738
      Location:175 → 473
      LRRFIP; LRRFIP family
      pfam11932
      Location:489 → 548
      DUF3450; Protein of unknown function (DUF3450)

    12. XM_036162414.1 → XP_036018307.1  leucine-rich repeat flightless-interacting protein 1 isoform X16

      Conserved Domains (2) summary
      pfam09738
      Location:175 → 442
      LRRFIP; LRRFIP family
      pfam11932
      Location:458 → 517
      DUF3450; Protein of unknown function (DUF3450)

    13. XM_036162407.1 → XP_036018300.1  leucine-rich repeat flightless-interacting protein 1 isoform X7

      UniProtKB/TrEMBL
      E9Q9T1
      Conserved Domains (2) summary
      pfam09738
      Location:184 → 513
      LRRFIP; LRRFIP family
      pfam11932
      Location:529 → 588
      DUF3450; Protein of unknown function (DUF3450)

    14. XM_036162413.1 → XP_036018306.1  leucine-rich repeat flightless-interacting protein 1 isoform X15

      Conserved Domains (2) summary
      pfam09738
      Location:162 → 453
      LRRFIP; LRRFIP family
      pfam11932
      Location:469 → 528
      DUF3450; Protein of unknown function (DUF3450)

    15. XM_017319000.2 → XP_017174489.1  leucine-rich repeat flightless-interacting protein 1 isoform X10

      UniProtKB/TrEMBL
      E9Q9T1
      Conserved Domains (2) summary
      pfam09738
      Location:162 → 491
      LRRFIP; LRRFIP family
      pfam11932
      Location:507 → 566
      DUF3450; Protein of unknown function (DUF3450)

    16. XM_036162428.1 → XP_036018321.1  leucine-rich repeat flightless-interacting protein 1 isoform X23

      Conserved Domains (2) summary
      pfam09738
      Location:52 → 375
      LRRFIP; LRRFIP family
      pfam11932
      Location:391 → 450
      DUF3450; Protein of unknown function (DUF3450)

    17. XM_030251813.1 → XP_030107673.1  leucine-rich repeat flightless-interacting protein 1 isoform X22

      UniProtKB/TrEMBL
      Q8BLV4
      Conserved Domains (2) summary
      pfam09738
      Location:52 → 379
      LRRFIP; LRRFIP family
      pfam11932
      Location:395 → 454
      DUF3450; Protein of unknown function (DUF3450)

    18. XM_030251811.1 → XP_030107671.1  leucine-rich repeat flightless-interacting protein 1 isoform X17

      Conserved Domains (2) summary
      pfam09738
      Location:52 → 417
      LRRFIP; LRRFIP family
      pfam11932
      Location:433 → 492
      DUF3450; Protein of unknown function (DUF3450)

    19. XM_030251812.1 → XP_030107672.1  leucine-rich repeat flightless-interacting protein 1 isoform X20

      Conserved Domains (2) summary
      pfam09738
      Location:52 → 386
      LRRFIP; LRRFIP family
      pfam11932
      Location:402 → 461
      DUF3450; Protein of unknown function (DUF3450)

    20. XM_030251816.1 → XP_030107676.1  leucine-rich repeat flightless-interacting protein 1 isoform X25

      UniProtKB/TrEMBL
      Q8BLV4
      Conserved Domains (2) summary
      pfam09738
      Location:52 → 355
      LRRFIP; LRRFIP family
      pfam11932
      Location:371 → 430
      DUF3450; Protein of unknown function (DUF3450)

    21. XM_030251823.1 → XP_030107683.1  leucine-rich repeat flightless-interacting protein 1 isoform X32

      Conserved Domains (2) summary
      pfam09738
      Location:52 → 415
      LRRFIP; LRRFIP family
      pfam11932
      Location:431 → 490
      DUF3450; Protein of unknown function (DUF3450)

    22. XM_030251821.1 → XP_030107681.1  leucine-rich repeat flightless-interacting protein 1 isoform X31

      UniProtKB/TrEMBL
      Q8BLV4
      Conserved Domains (2) summary
      pfam09738
      Location:52 → 384
      LRRFIP; LRRFIP family
      pfam11932
      Location:400 → 459
      DUF3450; Protein of unknown function (DUF3450)

    23. XM_030251824.1 → XP_030107684.1  leucine-rich repeat flightless-interacting protein 1 isoform X33

      Conserved Domains (2) summary
      pfam09738
      Location:52 → 391
      LRRFIP; LRRFIP family
      pfam11932
      Location:407 → 466
      DUF3450; Protein of unknown function (DUF3450)

    24. XM_030251814.1 → XP_030107674.1  leucine-rich repeat flightless-interacting protein 1 isoform X24

      UniProtKB/TrEMBL
      Q8BLV4
      Conserved Domains (2) summary
      pfam09738
      Location:52 → 360
      LRRFIP; LRRFIP family
      pfam11932
      Location:376 → 435
      DUF3450; Protein of unknown function (DUF3450)

    25. XM_006529216.3 → XP_006529279.1  leucine-rich repeat flightless-interacting protein 1 isoform X29

      See identical proteins and their annotated locations for XP_006529279.1

      UniProtKB/TrEMBL
      Q8BLV4
      Conserved Domains (2) summary
      pfam09738
      Location:52 → 329
      LRRFIP; LRRFIP family
      pfam11932
      Location:345 → 404
      DUF3450; Protein of unknown function (DUF3450)

    26. XM_036162410.1 → XP_036018303.1  leucine-rich repeat flightless-interacting protein 1 isoform X11

      UniProtKB/TrEMBL
      E9Q9T1
      Conserved Domains (2) summary
      pfam09738
      Location:152 → 481
      LRRFIP; LRRFIP family
      pfam11932
      Location:497 → 556
      DUF3450; Protein of unknown function (DUF3450)

    27. XM_036162419.1 → XP_036018312.1  leucine-rich repeat flightless-interacting protein 1 isoform X19

      Conserved Domains (2) summary
      pfam09738
      Location:98 → 396
      LRRFIP; LRRFIP family
      pfam11932
      Location:412 → 471
      DUF3450; Protein of unknown function (DUF3450)

    28. XM_036162433.1 → XP_036018326.1  leucine-rich repeat flightless-interacting protein 1 isoform X27

      Conserved Domains (2) summary
      pfam09738
      Location:42 → 345
      LRRFIP; LRRFIP family
      pfam11932
      Location:361 → 420
      DUF3450; Protein of unknown function (DUF3450)

    29. XM_036162434.1 → XP_036018327.1  leucine-rich repeat flightless-interacting protein 1 isoform X28

      UniProtKB/TrEMBL
      Q8BLV4
      Conserved Domains (2) summary
      pfam09738
      Location:42 → 343
      LRRFIP; LRRFIP family
      pfam11932
      Location:359 → 418
      DUF3450; Protein of unknown function (DUF3450)

    30. XM_006529214.2 → XP_006529277.1  leucine-rich repeat flightless-interacting protein 1 isoform X21

      See identical proteins and their annotated locations for XP_006529277.1

      Conserved Domains (2) summary
      pfam09738
      Location:42 → 381
      LRRFIP; LRRFIP family
      pfam11932
      Location:397 → 456
      DUF3450; Protein of unknown function (DUF3450)

    31. XM_036162432.1 → XP_036018325.1  leucine-rich repeat flightless-interacting protein 1 isoform X26

      Conserved Domains (2) summary
      pfam09738
      Location:42 → 350
      LRRFIP; LRRFIP family
      pfam11932
      Location:366 → 425
      DUF3450; Protein of unknown function (DUF3450)

    32. XM_006529215.2 → XP_006529278.1  leucine-rich repeat flightless-interacting protein 1 isoform X30

      Conserved Domains (2) summary
      pfam09738
      Location:42 → 319
      LRRFIP; LRRFIP family
      pfam11932
      Location:335 → 394
      DUF3450; Protein of unknown function (DUF3450)

    33. XM_036162418.1 → XP_036018311.1  leucine-rich repeat flightless-interacting protein 1 isoform X18

      Conserved Domains (2) summary
      pfam09738
      Location:47 → 400
      LRRFIP; LRRFIP family
      pfam11932
      Location:416 → 475
      DUF3450; Protein of unknown function (DUF3450)

    RNA

    1. XR_004940657.1 RNA Sequence

    2. XR_004940659.1 RNA Sequence

    3. XR_004940661.1 RNA Sequence

    4. XR_004940660.1 RNA Sequence

    5. XR_004940663.1 RNA Sequence

    6. XR_004940664.1 RNA Sequence

    7. XR_004940667.1 RNA Sequence

    8. XR_004940666.1 RNA Sequence

    9. XR_004940670.1 RNA Sequence

    10. XR_004940665.1 RNA Sequence

    11. XR_004940669.1 RNA Sequence

    12. XR_004940668.1 RNA Sequence

    13. XR_004940658.1 RNA Sequence

    14. XR_004940662.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UZ39.2 GenPept UniProtKB/Swiss-Prot:Q3UZ39

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